Abdolrahman Shams-Nateri

Contact

• workRoom W/E 1282 E Floor, West Block
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 823 1306
• fax0115 823 1137
• a.nateri@nottingham.ac.uk

Teaching Summary

Cancer Genetics, Transgenic Murine Technology, Stem Cells, Reprogramming of Cancer Cells and Links between Signalling, Transcription and Diseases

Research Summary

Interests

· Since the last decade, it is believed that specific signalling pathways; "WNT and MAPK" that control crucial steps during embryonic development are often inappropriately reactivated during tumorigenesis. Cancer cells seem to take advantage of cellular principles inherent to normal stem cells which are crucial for maintenance, repair and regenerative processes of most adult tissues such as the intestinal epithelium system. Intestinal Epithelial Stem (IES) cell self-renewal is a physiological mechanism that not only maintains a small pool of (stem) cells that are able to proliferate indefinitely, but also at the same time produce a variety of differentiated cells that fulfil and maintain the function of the organ. Our research takes advantage of various mouse models in which the expression of a number of transcriptional modifiers (c-Jun, Fbw7 and TCF4/b-catenin) conditionally altered in the gut. We use those model systems to study the molecular and cellular basis of IES cell self-renewal, the interaction of stem cells with their specialized microenvironment (stem cell niche) and the relationship between stem cells and tumorigenesis.

Techniques

· Epithelial stem cells assay (in vivo and in vitro), mouse genetics, gene targeting/transgenic, Cre/loxP system, transcriptome/ proteome analysis, ex vivo cell culture, FACS, histology, RNA and protein expression studies in vitro and in vivo.

Projects

· Our focus of studies will further extend the use of mouse models to study normal & malignant gastrointestinal tissues development as well as the intestinal epithelial stem cell biology. Our aim is to use these insights:

· to develop strategies that would allow expansion of adult stem cells in vitro and obtain insights into development and the pathological events that lead to the cancer of the gut.

· to understand the molecular mechanism of the links between signalling, transcription and diseases that controls the nature of stem cell and their progenitor lineage compartments and the nature of a "stem cell niche".

Grant funding

· MRC

· CRUK

Selected Publications

• BABAEI-JADIDI, R and N. LI, A. SAADEDDIN, B. SPENCER-DENE, A. JANDKE, B. MUHAMMAD, E.E. IBRAHIM, R. MURALEEDHARAN, M. ABUZINADAH, H. DAVIS, A. LEWIS, S. WATSON, A. BEHRENS, I. TOMLINSON, AND A.S. NATERI., 2011. FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation. The Journal of experimental medicine. 208(2), 295-312
• SAADEDDIN, ANAS, BABAEI-JADIDI, ROYA, SPENCER-DENE, BRADLEY and NATERI, ABDOLRAHMAN SHAMS, 2009. The links between transcription, beta-catenin/JNK signaling, and carcinogenesis. Molecular cancer research : MCR. 7(8), 1189-96
• NATERI, A.S., SPENCER-DENE, B. and BEHRENS, A., 2005. Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development Nature. 437, 281-285
• SANCHO, ROCIO, NATERI, ABDOLRAHMAN S, DE VINUESA, AMAYA GARCIA, AGUILERA, CRISTINA, NYE, EMMA, SPENCER-DENE, BRADLEY and BEHRENS, AXEL, 2009. JNK signalling modulates intestinal homeostasis and tumourigenesis in mice. The EMBO journal. 28(13), 1843-54

• View all publications

• BABAEI-JADIDI, R and N. LI, A. SAADEDDIN, B. SPENCER-DENE, A. JANDKE, B. MUHAMMAD, E.E. IBRAHIM, R. MURALEEDHARAN, M. ABUZINADAH, H. DAVIS, A. LEWIS, S. WATSON, A. BEHRENS, I. TOMLINSON, AND A.S. NATERI., 2011. FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation. The Journal of experimental medicine. 208(2), 295-312
• AL-GHAMDI, SALEH, ALBASRI, ABDULKADER, CACHAT, JULIEN, IBRAHEM, SALIH, MUHAMMAD, BELAL A, JACKSON, DARRYL, NATERI, ABDOLRAHMAN S, KINDLE, KARIN B and ILYAS, MOHAMMAD, 2011. Cten is targeted by Kras signalling to regulate cell motility in the colon and pancreas. PloS one. 6(6), e20919
• DA COSTA, CLIVE R, VILLADIEGO, JAVIER, SANCHO, ROCIO, FONTANA, XAVIER, PACKHAM, GRAHAM, NATERI, ABDOLRAHMAN S and BEHRENS, AXEL, 2010. Bag1-L is a phosphorylation-dependent coactivator of c-Jun during neuronal apoptosis. Molecular and cellular biology. 30(15), 3842-52
• ALBASRI, ABDULKADER, SETH, RASHMI, JACKSON, DARRYL, BENHASOUNA, AHMED, CROOK, SIMON, NATERI, ABDOLRAHMAN S, CHAPMAN, ROGER and ILYAS, MOHAMMAD, 2009. C-terminal Tensin-like (CTEN) is an oncogene which alters cell motility possibly through repression of E-cadherin in colorectal cancer. The Journal of pathology. 218(1), 57-65
• GAVRILIN, MIKHAIL A, MITRA, SRABANI, SESHADRI, SUDARSHAN, NATERI, JYOTSNA, BERHE, FREWEINE, HALL, MARK W and WEWERS, MARK D, 2009. Pyrin critical to macrophage IL-1beta response to Francisella challenge. Journal of immunology (Baltimore, Md. : 1950). 182(12), 7982-9
• SAADEDDIN, ANAS, BABAEI-JADIDI, ROYA, SPENCER-DENE, BRADLEY and NATERI, ABDOLRAHMAN SHAMS, 2009. The links between transcription, beta-catenin/JNK signaling, and carcinogenesis. Molecular cancer research : MCR. 7(8), 1189-96
• SANCHO, ROCIO, NATERI, ABDOLRAHMAN S, DE VINUESA, AMAYA GARCIA, AGUILERA, CRISTINA, NYE, EMMA, SPENCER-DENE, BRADLEY and BEHRENS, AXEL, 2009. JNK signalling modulates intestinal homeostasis and tumourigenesis in mice. The EMBO journal. 28(13), 1843-54
• NATERI, ABDOLRAHMAN S, RAIVICH, GENNADIJ, GEBHARDT, CHRISTINE, DA COSTA, CLIVE, NAUMANN, HEIKE, VREUGDENHIL, MARTIN, MAKWANA, MILAN, BRANDNER, SEBASTIAN, ADAMS, RALF H, JEFFERYS, JOHN G R and KANN, OLIVE, 2007. ERK activation causes epilepsy by stimulating NMDA receptor activity. The EMBO journal. 26(23), 4891-901
• NATERI, A.S., SPENCER-DENE, B. and BEHRENS, A., 2005. Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development Nature. 437, 281-285
• NATERI, A S, TZAVELAS, C, BILDIRICI, L and RICKWOOD, D, 2005. Transfection of human peripheral blood mononuclear cells using immunoporation. Journal of immunoassay & immunochemistry. 26(3), 169-77
• NATERI, ABDOLRAHMAN S, SPENCER-DENE, BRADLEY and BEHRENS, AXEL, 2005. Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature. 437(7056), 281-5
• RAIVICH, GENNADIJ, BOHATSCHEK, MARION, DA COSTA, CLIVE, IWATA, OSUKE, GALIANO, MATTHIAS, HRISTOVA, MARIA, NATERI, ABDOLRAHMAN S, MAKWANA, MILAN, RIERA-SANS, LLUÍS, WOLFER, DAVID P and LIPP, HANS-PET, 2004. The AP-1 transcription factor c-Jun is required for efficient axonal regeneration. Neuron. 43(1), 57-67
• NATERI, ABDOLRAHMAN S, RIERA-SANS, LLUÍS, DA COSTA, CLIVE and BEHRENS, AXEL, 2004. The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling. Science. 303(5662), 1374-8
• RAIVICH, G., BOHATSCHEK, M., DA COSTA, C., IWATA, O., GALIANO, M., HRISTOVA, M., NATERI, A.S., MAKWANA, M., RIERA-SANS, L., WOLFER, D.P, LIPP, H.P., AGUZZI, A., WAGNER, E.F. and BEHRENS, A., 2004. The AP-1 transcription factor c-Jun is required for efficient axonal regeneration Neuron. 43(1), 57-67
• NATERI, A.S., RIERA-SANS, L., DA COSTA, C. and BEHRENS, A., 2004. The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling Science. 303(5662), 1374-1378
• NATERI, A.S., HUGHES, P.J. and STANWAY, G., 2002. Terminal RNA replication elements in human parechovirus 1 Journal of Virology. 76(24), 13116-13122
• NATERI, ABDOLRAHMAN S, HUGHES, PAMELA J and STANWAY, GLYN, 2002. Terminal RNA replication elements in human parechovirus 1. Journal of Virology. 76(24), 13116-22
• NATERI, A S, HUGHES, P J and STANWAY, G, 2000. In vivo and in vitro identification of structural and sequence elements of the human parechovirus 5' untranslated region required for internal initiation. Journal of Virology. 74(14), 6269-77