Iain Moppett

Contact

• workRoom E/C1719 Queen's Medical Centre
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 82 30959
• iain.moppett@nottingham.ac.uk

Biography

Iain Moppett is a research active associate professor and honorary consultnat anaesthetist. His research interests are focussed on four main areas.

1) The impact of fluid management on outcomes following surgery.

His team is currently recruiting patients as part of an NIHR funded trial into hip fracture outcome. He is an invited researcher for the forthcoming Optimise trial into outcome following major GI surgery. Further work is planned regarding the accuracy of preload responsiveness indicators in different clinical groups.

2) Modelling the response of cerebral blood flow to physiological and pathological changes.

His team is developing a computational model to investigate, and predict blood flow changes associated with surgery and injury.

3) The impact of peri-operative management on outcome following hip fracture.

As well as a current study on the effects of intra-oeprative fluid management on hip fracture outcome, Dr Moppett is colloborating with colleagues from orthopaedics, anaesthesia and orthogeriatrics on future studies aiming to optimise quantitative and qualitative outcome for this high risk group.

4) Sugammadex and anaesthesia

As well as being a key UK researcher in the Phase II and III trials of sugammadex, Dr Moppett is underataking Phase IV studies as well as outcome / efficiency modelling studies with this novel drug.

Selected Publications

• MAXWELL, M J, MORAN, C G and MOPPETT, I K, 2008. Development and validation of a preoperative scoring system to predict 30 day mortality in patients undergoing hip fracture surgery. British journal of anaesthesia. 101(4), 511-7
• WILES, M D, MORAN, C G, SAHOTA, O and MOPPETT, I K, 2011. Nottingham Hip Fracture Score as a predictor of one year mortality in patients undergoing surgical repair of fractured neck of femur. British journal of anaesthesia. 106(4), 501-4
• MOPPETT IK, WILES MD, MORAN CG and SAHOTA O, 2011. The Nottingham Hip Fracture Score As A Predictor Of Early Discharge Following Fractured Neck Of Femur. Age And Ageing. (In Press.)
• RAMANATHAN, T.S., MOPPETT, I.K., WENN, R.T. and MORAN, C.G., 2004. POSSUM scoring in fractured neck of femur. British Journal of Anaesthesia. 93(1), 161

• View all publications

• WILES, MATTHEW D, HARVEY, DANIEL J R, COLEMAN, JAIMIE and MOPPETT, IAIN K, 2011. Computed tomography of the brain in the emergency department: how often is tracheal intubation and general anaesthesia required? European journal of emergency medicine : official journal of the European Society for Emergency Medicine. 18(2), 115-6
• CHIKHANI, M and MOPPETT, I K, 2011. Minimally invasive cardiac output monitoring: what evidence do we need? British journal of anaesthesia. 106(4), 451-3
• WILES, M D, MORAN, C G, SAHOTA, O and MOPPETT, I K, 2011. Nottingham Hip Fracture Score as a predictor of one year mortality in patients undergoing surgical repair of fractured neck of femur. British journal of anaesthesia. 106(4), 501-4
• WILES MD, WHITELEY WJD, MORAN CG and MOPPETT IK, 2011. The Use Of Lidco Based Fluid Management In Patients Undergoing Hip Fracture Surgery Under Spinal Anaesthesia: Neck Of Femur Optimisation Therapy - Targeted Stroke Volume (Notts): Study Protocol For A Randomized Controlled Trial. Trials. 12, 213
• MOPPETT IK, WILES MD, MORAN CG and SAHOTA O, 2011. The Nottingham Hip Fracture Score As A Predictor Of Early Discharge Following Fractured Neck Of Femur. Age And Ageing. (In Press.)
• DE HERT S, IMBERGER G, CARLISLE J, DIEMUNSCH P, FRITSCH G, MOPPETT I, SOLCA M, STAENDER S, WAPPLER F, SMITH A and TASK FORCE ON PREOPERATIVE EVALUATION OF THE ADULT NONCARDIAC SURGERY PATIENT OF THE EUROPEAN SOCIETY OF ANAESTHESIOLOGY, 2011. Preoperative Evaluation Of The Adult Patient Undergoing Non-Cardiac Surgery: Guidelines From The European Society Of Anaesthesiology. European Journal Of Anaesthesiology. 28(10), 684-722
• MOPPETT IK and HARDMAN JG, 2011. Bibliometrics Of Anaesthesia Researchers In The Uk. British Journal Of Anaesthesia. 107(3), 351-6
• MOPPETT, IAN, 2010. Letter to the editor: New equations for predicting postoperative risk in patients with hip fracture. Clinical orthopaedics and related research. 468(6), 1705; author reply 1706-7
• HARDMAN, J G and MOPPETT, I K, 2010. To err is human. British journal of anaesthesia. 105(1), 1-3
• WILES, M D, DOBSON, S A and MOPPETT, I K, 2010. The effect of a new topical local anaesthetic delivery system on forearm skin blood flow reactivity. Anaesthesia. 65(2), 178-83
• JAMJOOM, A A B, WHITE, S, WALTON, S M, HARDMAN, J G and MOPPETT, I K, 2010. Anaesthetists' and surgeons' attitudes towards informed consent in the UK: an observational study. BMC medical ethics. 11, 2
• MOPPETT, I K, HARDMAN, G and SHAH, A, 2009. Performance of oxygen delivery devices with simulated respiratory failure. Anaesthesia. 64(2), 227-8
• MOPPETT, I K, 2009. Sympathetic activity and cerebral oxygenation. British journal of anaesthesia. 103(5), 769; author reply 769-70
• BEED, M, O'CONNOR, M B, KAUR, J, MAHAJAN, R P and MOPPETT, I K, 2009. Transient hyperaemic response to assess skin vascular reactivity: effects of heat and iontophoresed norepinephrine. British journal of anaesthesia. 102(2), 205-9
• MOPPETT, I K, SHERMAN, R W, WILD, M J, LATTER, J A and MAHAJAN, R P, 2008. Effects of norepinephrine and glyceryl trinitrate on cerebral haemodynamics: transcranial Doppler study in healthy volunteers. British journal of anaesthesia. 100(2), 240-4
• MAXWELL, M J, MORAN, C G and MOPPETT, I K, 2008. Development and validation of a preoperative scoring system to predict 30 day mortality in patients undergoing hip fracture surgery. British journal of anaesthesia. 101(4), 511-7
• WILES, M D, DICKSON, E and MOPPETT, I K, 2008. Transient hyperaemic response to assess vascular reactivity of skin: effect of topical anaesthesia. British journal of anaesthesia. 101(3), 320-3
• HARDMAN, J G, MOPPETT, I K and MAHAJAN, R P, 2008. Validity, credibility, and applicability: the rise and rise of the surrogate. British journal of anaesthesia. 101(5), 595-6
• WILES, M and MOPPETT, I, 2008. Accuracy of hospital clocks. Anaesthesia. 63(7), 786-7
• MOPPETT, I.K. and HARDMAN, J.G., 2007. Modeling the causes of variation in brain tissue oxygenation. Anesthesia and Analgesia. 105(4), 1104-1112
• MOPPETT, I.K. and HARDMAN, J.G., 2007. Development and validation of an integrated computational model of cerebral blood flow and oxygenation Anesthesia and Analgesia. 105, 1094-1103
• MOPPETT, I K, 2007. Traumatic brain injury: assessment, resuscitation and early management. British Journal of Anaesthesia. 99(1), 18-31
• MOPPETT, IAIN K and HARDMAN, JONATHAN G, 2007. Development and validation of an integrated computational model of cerebral blood flow and oxygenation. Anesthesia and analgesia. 105(4), 1094-103, table of contents
• MCCAHON, R A, MOPPETT, I K and HARDMAN, J G, 2007. Ephedrine, phenylephrine and BIS during propofol anaesthesia. European Journal of Anaesthesiology. 24(6), 559-60; author reply 560
• MOPPETT, I., 2007. Transcranial Doppler in the Intensive Care Unit and Operating Room. In: HARMON, D., FRIZELLE, H.P., SANDHU, N.S., COLREAVY, F.B. and GRIFFIN, M., eds., Perioperative Diagnostic and Interventional Ultrasound Elsevier, Edinburgh, Scotland.
• MOPPETT, IAIN K and HARDMAN, JONATHAN G, 2007. Modeling the causes of variation in brain tissue oxygenation. Anesthesia and analgesia. 105(4), 1104-12, table of contents
• SHIELDS, M., GIOVANNELLI, M., MIRAKHUR, R.K., MOPPETT, I., ADAMS, J. and HERMENS, Y., 2006. Org 25969 (sugammadex), a selective relaxant binding agent for antagonism of prolonged rocuronium-induced neuromuscular block British Journal of Anaesthesia. 96(1), 36-43
• MOPPETT, I. and HARDMAN, J.G., 2006. Factors affecting indices of cerebral autoregulation: a computational modelling study British Journal of Anaesthesia. 96(2), 286P
• MOPPETT, I.K., GORNALL, C.B. and HARDMAN, J.G., 2005. The dependence of measured alveolar deadspace on anatomical deadspace volume British Journal of Anaesthesia. 95(3), 400-405
• RAMANATHAN, T.S., MOPPETT, I.K., WENN, R. and MORAN, C.G., 2005. POSSUM scoring for patients with fractured neck of femur British Journal of Anaesthesia. 94(4), 430-433
• BEED, M., KAUR, J., MOPPETT, I.K. and MAHAJAN, R.P., 2005. The effect of iontophoresed norepinephrine and heat on skin vascular reactivity as assessed by the transient hyperaemic response in human volunteers British Journal of Anaesthesia. 94(3), 409P-410P
• MAHAJAN, R. and MOPPETT, I., 2005. Cardiovascular support in critical care. In: Critical Care for Postgraduate Trainees Hodder Arnold, London, UK. 49-66
• BANKS, A., MOPPETT, I., FLETCHER, R. and HARDMAN, J.G., 2005. The influence of anatomical shunt on alveolar dead space fraction British Journal of Anaesthesia. 93(1), 160-161
• KNIGHT, D.J., MOPPETT, I. and HARDMAN, J.G., 2005. A model of respiratory drive in acute exacerbations of COPD British Journal of Anaesthesia. 92(2), 308
• SHIELDS, M., GIOVANNELLI, M., MIRAKHUR, R.K., MOPPETT, I., ADAMS, J., HERMES, Y. and MAHAJAN, R.P., 2005. A selective relaxant binding agent for antagonism of prolonged rocuronium-induced neuromuscular block European Journal of Anaesthesiology. 22, A535
• MOPPETT, I K, GORNALL, C B and HARDMAN, J G, 2005. The dependence of measured alveolar deadspace on anatomical deadspace volume. British journal of anaesthesia. 95(3), 400-5
• ENGLISH, J D and MOPPETT, I K, 2005. Evaluation of a trans-oesophageal Doppler probe in awake subjects. Anaesthesia. 60(7), 720-1
• MOPPETT, I. and SPENDLOVE, J., 2004. Manufacturers' response to criticism Anaesthesia. VOL 59(NUMBER 11), 1143-1143
• MOPPETT, I., WILD, M.J., SHERMAN, R., LATTER, J.A., MILLER, K. and MAHAJAN, R.P., 2004. Effects of ephidrine, dobutamine and dopexamine on cerebral haemodynamics : transcranial Doppler studies in healthy volunteers. British Journal of Anaesthesia. 92(1), 39-44
• MOPPETT, I K and MAHAJAN, R P, 2004. Transcranial Doppler ultrasonography in anaesthesia and intensive care. British Journal of Anaesthesia. 93(5), 710-24
• GRAY, N.J., MCLUSKEY, J., MOPPETT, I., PRINGLE, A. and TRUEMAN, I., 2004. Patients as assessors of students: stakeholder opinions in medicine, nursing and pharmacy International Journal of Pharmacy Practice. 12, R48
• PERRIN, M.E., HANCOCK, S.M., MOPPETT, I. and MAHAJAN, R., 2004. Changes in total peripheral resistance and zero flow pressure in the cerebral circulation during a Valsalva manoeuvre European Journal of Anaesthesiology. 21, A408
• RICHARDSON, J., MOPPETT, I. and MAHAJAN, R., 2004. The effect of changes in end-tidal carbon dioxide on vascular reactivity of skin European Journal of Anaesthesiology. 21, A251
• PERRIN, M.E., MOPPETT, I.K. and MAHAJAN, R.P., 2004. Assessment of forearm skin blood flow reactivity: the effect of exercise on the transient hyperaemic response British Journal of Anaesthesia. 316-316
• RAMANATHAN, T.S., MOPPETT, I.K., WENN, R.T. and MORAN, C.G., 2004. POSSUM scoring in fractured neck of femur. British Journal of Anaesthesia. 93(1), 161
• MARVAL, P.D., MOPPETT, I.K. and MAHAJAN, R.P., 2004. Moderate changes in oxygen tension in blood have no effect on the reactive hyperaemia of the forearm skin following brief tourniquet occlusion of the upper limb British Journal of Anaesthesia. 316-316
• ABAZA, K.T., MOPPETT, I. and MAHAJAN, R., 2004. The effect of age on the transient hyperaemic response of forearm skin Journal of Physiology. PC46a
• MOPPETT, I.K., SZYPULA, K. and YEOMAN, P.M., 2004. Comparison of EMLA and lidocaine iontophoresis for cannulation analgesia European Journal of Anaesthesiology. 21(3), 210-213
• DAVEY, A and MOPPETT, I K, 2004. Postoperative complications after CS spray exposure. Anaesthesia. 59(12), 1219-20
• MOPPETT, I and SPENDLOVE, J, 2004. Manufacturers' response to criticism. Anaesthesia. 59(11), 1143; discussion 1143
• BROWN, H, MOPPETT, I K and MAHAJAN, R P, 2003. Transient hyperaemic response to assess vascular reactivity of skin: effect of locally iontophoresed acetylcholine, bradykinin, epinephrine and phenylephrine. British Journal of Anaesthesia. 90(4), 446-51
• MOPPETT, I K, DAVIES, J A and MAHAJAN, R P, 2003. Non-selective and cyclo-oxygenase-2-specific non-steroidal anti-inflammatory drugs impair the hyperaemic response of skin to brief axillary artery occlusion. British Journal of Anaesthesia. 91(3), 353-6
• KNIGHT, D.J.W., MOPPETT, I.K. and HARDMAN, J.G., 2003. Breathing pattern and workload during automatic tube compensation, pressure support and T-piece trials in weaning patients European Journal of Anaesthesiology. 20(11), 932
• GORNALL, C.B., MOPPETT, I. and HARDMAN, J.G., 2003. The dependence of measured alveolar deadspace on airways deadspace volume British Journal of Anaesthesia. 90(3), 412-413
• O'CONNOR, M.B., MOPPETT, I.K. and MAHAJAN, R.P., 2003. The effects of local heat changes in temperature on skin vascular reactivity as assessed using transient hyperaemic response in the forearm British Journal of Anaesthesia. 414P-415P
• KNIGHT, D.J.W., MOPPETT, I. and HARDMAN, J.G., 2003. Predicting carbon dioxide retention in acute exacerbations of COPD Thorax. 58(3), 16
• MOPPETT, I.K., JONES, L.N. and MAHAJAN, R.P., 2003. The effect of ischaemia on the transient hyperaemic response of forearm skin British Journal of Anaesthesia. 822P-822P
• KNIGHT, D.J., MOPPETT, I. and HARDMAN, J.G., 2003. The effect of varying inspired oxygen fraction on respiratory dead space and partial pressure of arterial carbon dioxide: a modelling study British Journal of Anaesthesia. 90(6), 828-829
• KNIGHT, D J W, MOPPETT, I K and HARDMAN, J G, 2003. Breathing pattern and workload during automatic tube compensation, pressure support and T-piece trials in weaning patients. European journal of anaesthesiology. 20(11), 932; author reply 933
• STACEY, M., MOPPETT, I., ATHANASSIOU, L. and MAHAJAN, R., 2002. The effect of systemic compliance on the noninvasive assessment of zero-flow pressure in a bench model of pulsatile flow British Journal of Anaesthesia. 196P-196P
• MOPPETT, I.K., GORNALL, C.B., HANCOCK, S.M. and MAHAJAN, R.P., 2002. Factors affecting the siphon effect in simulated cerebral circulation using a bench model British Journal of Anaesthesia. 196P-197P
• MOPPETT, I.K., MILLER, K., DAVIES, J.A., BAXENDALE, B.R. and MAHAJAN, R.P., 2002. The effects of dopexamine on cerebral carbon dioxide reactivity British Journal of Anaesthesia. 204P-205P
• MOPPETT, I.K., MALIK, M. and BAXENDALE, B.R., 2002. Transoesophageal Doppler measurements are tolerable and reproducible in awake, ambulatory volunteers British Journal of Anaesthesia. 358P-358P
• MOPPETT, I. and CURRAN, J., 2001. Smoking and the surgical patient Continuing Education in Anaesthesia, Critical Care & Pain. 122-124
• MOPPETT, I. and SHAJAR, M., 2001. Transoesophageal echocardiography Continuing Education in Anaesthesia, Critical Care & Pain. 72-75
• CARRADICE, D, ALAGESAN, K and MOPPETT, I, 2000. An unusual case of 'gastro-oesophageal reflux'. Anaesthesia. 55(11), 1134-5;author reply 1135-6
• CARRADICE, D., ALAGESAN, K., MOPPETT, I. and KNOWLES, J., 2000. An unusual case of `gastro-oesophageal reflux' Anaesthesia. VOL 55(PART 11), 1134-1135
• NATHANSON, MICHAEL, MOPPETT, IAIN K and WILES, MATT, eds., Neuroanaesthesia Oxford : Oxford University Press, 2010..
• HARDMAN, JONATHON G, MOPPETT, IAIN K and AITKENHEAD, A. R, eds., Consent, benefit, and risk in anaesthetic practice Oxford : Oxford University Press, 2009..