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John Scholefield

Professor of Surgery/ Consultant General and Colorectal Surgeon, Faculty of Medicine & Health Sciences

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Research Summary

Pharmacology of the anal sphincter, novel treatments for faecal incontinence and for anal fissures

Colorectal cancer screening

Molecular changes in early colorectal cancer

Radiotherapy in rectal cancer

Immunotherapy for colorectal cancer

Anal cancer and pre-malignant conditions

Techniques

  • In vivo models for anal sphincter physiology
  • clinical trials in anorectal disease
  • Screening for colorectal cancer

Projects

  • Immunotherapy in treatment of patients with primary colorectal cancer
  • Sphincter pharmacology - (The Sir Jules Thorn Charitable Trust, Norgine, Help the Aged) (Norgine) (Help the Aged)
  • Follow up of the Nottingham Faecal Occult Blood Test Screening Cohort (Medical Research Council)
  • Research Fellowship investigating the mechanisms of symptomatic diverticular disease (with J. Simpson) (Medical Research Council and Royal College of Surgeons)
  • Health economics of colorectal cancer follow-up (Southern Derbyshire NHS Trust)

Recent Publications

  • HUMES DJ, SIMPSON J, SMITH J, SUTTON P, ZAITOUN A, BUSH D, BENNETT A, SCHOLEFIELD JH, SPILLER R C, 2012. Visceral Hypersensitivity In Symptomatic Diverticular Disease And The Role Of Neuropeptides And Low Grade Inflammation Neurogastroenterology And Motility: The Official Journal Of The European Gastrointestinal Motility Society. (In Press.)
  • SIMPSON JA, SCHOLEFIELD JH, 2011. Diagnosis and management of anal intraepithelial neoplasia and anal cancer BMJ. Nov 4, 343
  • SCHOLEFIELD JH, MOSS SM, MANGHAM CM, WHYNES DK, HARDCASTLE JD, 2011. Nottingham trial of faecal occult blood testing for colorectal cancer: a 20-year-followup GUT.
  • LOHSIRIWAT V, SCHOLEFIELD JH, DASHWOOD MR, WILSON VG, 2011. Pharmacological characteristics of endothelin receptors on sheep rectal blood vessels Pharmacol Research. 63(6), 490-5

School of Clinical Sciences

D Floor, East Block
Queen's Medical Centre
Nottingham, NG7 2UH

telephone: +44 (0) 115 823 0695
fax: +44 (0) 115 823 0704
email: scs-enquiries@nottingham.ac.uk