Nikola Sprigg

Contact

• workRoom B60 Clinical Sciences Building
  Nottingham City Hospital
  Hucknall Road
  Nottingham
  NG5 1PB
  UK
• work0115 82 31778
• fax0115 82 31767
• nikola.sprigg@nottingham.ac.uk

Biography

I am currently working in the Division of Stroke, University of Nottingham where I studied stroke recovery and the management of blood pressure in acute stroke as part of my Doctorate of Medicine, Clinical Studies of stroke recovery and potential enhancement with pharmacological intervention or stem cell mobilisation.

Expertise Summary

My current interests include developing treatments to improve recovery after stroke, treatment of haemorrhagic stroke, quality of life after stroke, management of blood pressure after stroke, venous thrombosis prophylaxis after stroke and anti-platelet treatment for the secondary prevention of stroke.

Principal investigator of two small studies: Stem cell Trial of recovery EnhanceMent after Stroke 3 (STEMS 3)- a pilot randomised controlled trial of G-CSF and therapy in chronic stroke and A randomised controlled trial of Tranexamic acid in Intracerebral Haemorrhage (TICH). ​National coordinator of EuroHyp-1, a European, multi-centre, phase III, clinical trial of hypothermia after stroke.

Research Summary

My current interests include developing treatments to improve recovery after stroke, quality of life after stroke, management of blood pressure after stroke, venous thrombosis prophylaxis after… read more

Selected Publications

• SPRIGG, NIKOLA, GRAY, LAURA J, ENGLAND, TIM, WILLMOT, MARK R, ZHAO, LIAN, SARE, GILLIAN M and BATH, PHILIP M W, 2008. A randomised controlled trial of triple antiplatelet therapy (aspirin, clopidogrel and dipyridamole) in the secondary prevention of stroke: safety, tolerability and feasibility. PLoS ONE. 3(8), e2852
• SPRIGG, N, MACHILI, C, OTTER, M E, WILSON, A and ROBINSON, T G, 2009. A systematic review of delays in seeking medical attention after transient ischaemic attack. Journal of neurology, neurosurgery, and psychiatry. 80(8), 871-5
• SPRIGG, and BATH,, 2009. Speeding stroke recovery? A systematic review of amphetamine after stroke. Journal of the neurological sciences. 285(1-2), 3-9
• SPRIGG, NIKOLA, GRAY, LAURA J, BATH, PHILIP M W, CHRISTENSEN, HANNE, DE DEYN, PETER PAUL, LEYS, DIDIER, O'NEILL, DESMOND, RINGELSTEIN, E BERND and ,, 2011. Quality of Life after Ischemic Stroke Varies in Western Countries: Data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST). Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

• View all publications

Current Research

My current interests include developing treatments to improve recovery after stroke, quality of life after stroke, management of blood pressure after stroke, venous thrombosis prophylaxis after stroke and anti-platelet treatment for the secondary prevention of stroke.

I am Principal Investigator of the ongoing RfPB Stem cell Trial of recovery EnhanceMent after Stroke 3' (STEMS 3)- a pilot randomised controlled trial of G-CSF and therapy in chronic stroke and Tranexamic acid in IntraCerebral Haemorrhage TICH phase II trials, and adjudicate SAEs and outcomes in ENOS and TARDIS. I was on the DMC for the MRC funded STEMS2 study and am on the DMC for the ongoing RfPB Neurovascular Imaging in Patients with Carotid Artery Disease study.

Past Research

I studied stroke recovery and the management of blood pressure in acute stroke as part of my Doctorate of Medicine, Clinical Studies of stroke recovery and potential enhancement with pharmacological intervention or stem cell mobilisation.

Future Research

My research interests include the natural history of recovery after stroke, potential enhancement of recovery with pharmacological agents or growth factors (G-CSF), and quality of life after stroke. I am also interested in depression after stroke.

I am going to be the National Co-ordinator for European multicentre, randomised, phase III clinical trial of hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke EuroHYP-1

• GEEGANAGE CM, BATH MW, SPRIGG N and BATH PM., 2012. Balance between preventing pulmonary embolism and causing symptomatic intracerebral haemorrhage with anticoagulation thromboprophylaxis in early ischaemic stroke: a systematic review and meta-analysis of randomised controlled trials. Journal of Stroke & Cerebrovascular Diseases. (In Press.)
• SANDEEP ANKOLEKAR, CHERYL HOGG, NIKOLA SPRIGG, PHILIP MW BATH and THE VISTA COLLABORATORS., 2012. The Cog-4 subset of the National Institute Health Stroke Scale as a measure of cognition: relationship with baseline factors and functional outcome after stroke using data from the Virtual International Stroke Trials Archive (VISTA) Stroke. (In Press.)
• SPRIGG, NIKOLA, GEEGANAGE, CHAMILA M and BATH, PHILIP M W, 2011. Should patients with stroke wear compression stockings? Annals of internal medicine. 154(7), 506
• SPRIGG, NIKOLA, GRAY, LAURA J, BATH, PHILIP M W, CHRISTENSEN, HANNE, DE DEYN, PETER PAUL, LEYS, DIDIER, O'NEILL, DESMOND, RINGELSTEIN, E BERND and ,, 2011. Quality of Life after Ischemic Stroke Varies in Western Countries: Data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST). Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.
• WHITEHEAD P, FELLOWS K, SPRIGG N AND DRUMMOND AER, 2010. Research governance- there is nothing streamlined about the system. At: BMJ 2010;341;c5633
• SPRIGG, and BATH,, 2009. Speeding stroke recovery? A systematic review of amphetamine after stroke. Journal of the neurological sciences. 285(1-2), 3-9
• SPRIGG, N, MACHILI, C, OTTER, M E, WILSON, A and ROBINSON, T G, 2009. A systematic review of delays in seeking medical attention after transient ischaemic attack. Journal of neurology, neurosurgery, and psychiatry. 80(8), 871-5
• SPRIGG, NIKOLA, GRAY, LAURA J, ENGLAND, TIM, WILLMOT, MARK R, ZHAO, LIAN, SARE, GILLIAN M and BATH, PHILIP M W, 2008. A randomised controlled trial of triple antiplatelet therapy (aspirin, clopidogrel and dipyridamole) in the secondary prevention of stroke: safety, tolerability and feasibility. PLoS ONE. 3(8), e2852
• SPRIGG,, WILLMOT,, GRAY,, SUNDERLAND,, POMEROY,, WALKER, and BATH,, 2007. Amphetamine increases blood pressure and heart rate but has no effect on motor recovery or cerebral haemodynamics in ischaemic stroke: a randomized controlled trial (ISRCTN 36285333). Journal of Human Hypertension. 21, 616-624
• SPRIGG,N, and BATH,P.M.W, 2007. Colony Stimulating Factors (Blood Growth Factors) Are Promising but Unproven for Treating Stroke. Stroke. 38, 1997-8
• BATH, PMW and SPRIGG, N, 2007. Colony stimulating factors (including erythropoietin, granulocyte colony stimulating factor and analogues) for stroke. Cochrane Database of Systematic Reviews. CD005207
• SPRIGG, N., GRAY, L.J., BATH, P.M.W., LINDENSTROM, E., BOYSEN, G., DE DEYN, P.P., FRISS, P., LEYS, D., MARTTILA, R., OLSSON, J-E., O'NEILL, D., RINGELSTEIN, E.B., VAN DER SANDE, J-J., TURPIE, A.G.G., FOR THE TAIST INVESTIGATORS and , 2007. Stroke severity, early recovery and outcome are each related with clinical classification of stroke: data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST) Journal of the Neurological Sciences. 254(1-2), 54-9
• SPRIGG, N., GRAY, L.J., BATH, P.M.W., LINDENSTROM, E., BOYSEN, G., DE DEYN, P.P., FRIIS, P., LEYS, D., MARTTILA, R., OLSSON, J.E., O'NEILL, D., RINGELSTEIN, E.B., VAN DER SANDE, J-J. and TURPIE, A.G.G., 2007. Early recovery and functional outcome are related with casual stroke subtype: data from the Tinzaparin in acute ischemic stroke trial Journal of Stroke and Cerebrovascular Diseases. 16(4), 180-4
• SPRIGG,, BATH,, ZHAO,, WILLMOT,, GRAY,, WALKER,, DENNIS, and RUSSELL,, 2006. Granulocyte-Colony-Stimulating Factor Mobilizes Bone Marrow Stem Cells in Patients With Subacute Ischemic Stroke. The Stem Cell Trial of Recovery EnhanceMent After Stroke (STEMS) Pilot Randomized, Controlled Trial (ISRCTN 16784092). Stroke.
• GRAY, L. J., SPRIGG, N., BATH, P. M. W., SORENSEN, P., LINDENSTROM, E., BOYSEN, G., DE DEYN, P. P., FRIIS, P., LEYS, D. and MARTTILA, R., 2006. Significant variation in mortality and functional outcome after acute ischaemic stroke between western countries: data from the tinzaparin in acute ischaemic stroke trial (TAIST) Journal of Neurology, Neurosurgery and Psychiatry. VOL 77(NUMB 3), 327-333
• GRAY, L.J., SPRIGG, N., RASHID, P.A., WILLMOT, M.R. and BATH, P.M.W., 2006. Effect of nitric oxide donors on blood pressure and pulse pressure in acute and subacute stroke Journal of Stroke and Cerebrovascular Diseases. 15(6), 245-249
• SPRIGG, N., GRAY, L. J., BATH, P. M. W., BOYSEN, G., DE DEYN, P. P., FRIIS, P., LEYS, D., MARTTILA, R., OLSSON, J.-E. and O NEILL, D., 2006. Relationship between outcome and baseline blood pressure and other haemodynamic measures in acute ischaemic stroke: data from the TAIST trial Journal of Hypertension. VOL 24(NUMB 7), 1413-1418
• BATH, P.M.W. and SPRIGG, N., 2006. Control of blood pressure after stroke. Hypertension. 48(2), 203-4
• SPRIGG, N., GRAY, L. J., BATH, P. M., BOYSEN, G., PAUL DE DEYN, P., LEYS, D., LINDENSTRØ M, E., O’ NEILL, D., RINGELSTEIN, B. and VAN DER SANDE, J. J., 2005. Compression Stockings and the Prevention of Symptomatic Venous Thromboembolism: Data From the Tinzaparin in Acute Ischemic Stroke Trial Journal of Stroke and Cerebrovascular Diseases. VOL 14(NUMBER 5), 203-209
• SPRIGG, N. and BATH, P., 2005. Management of blood pressure in acute stroke Practical Neurology. 5, 218-223
• ZHAO, L., SPRIGG, N., HEPTINSTALL, S. and BATH, P., 2005. Effects of granulocyte-colony stimulating factor on platelets and leukocyte function in whole blood in vitro. In: International Society of Thrombosis & Haemostasis. P02373
• BATH, P.M. and SPRIGG, N., 2005. Haemopoietic growth factors (including erythropoietin, granulocyte colony stimulating factor and analogues) for stroke. (Protocol) Cochrane Database of Systematic Reviews.
• SPRIGG, N., 2005. Pharmacological enhancement of recovery from stroke Current Medical Literature - Stroke Review. 33-39