Peter Marsters

Contact

• workRoom D1614 'D' Floor, East Block
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 82 30698
• fax0115 82 30704
• peter.marsters@nottingham.ac.uk

Teaching Summary

I'm principal lecturer on the M.Med.Sc. in Assisted Reproduction Technology degree.

Research Summary

Since 1999 I have utilised my molecular genetics and biochemistry background to develop research interests in the field of reproductive biology. I am particularly interested in widening the current… read more

Selected Publications

• NICKLIN, L.T, ROBINSON, R.S, MARSTERS, P, CAMPBELL, B.K, MANN, G.E. and HUNTER, M.G., 2007. Leptin in the bovine corpus luteum: Receptor expression and effects on progesterone production Molecular Reproduction and Development. 74(6), 724-729
• KENDALL, N R, MARSTERS, P, GUO, L, SCARAMUZZI, R J and CAMPBELL, B K, 2006. Effect of copper and thiomolybdates on bovine theca cell differentiation in vitro. Journal of Endocrinology. 189(3), 455-63
• CAMPBELL, B.K., SOUZA, C., GONG, J., WEBB, R., KENDALL, N., MARSTERS, P., ROBINSON, G., MITCHELL, A., TELFER, E.E. and BAIRD, D.T., 2003. Review: Domestic ruminants as models for the elucidation of the mechanisms controlling ovarian follicle development in humans. Reproduction. Supplement. 61, 429-443
• MARSTERS, P, KENDALL, N.R and CAMPBELL, B.K, 2003. Temporal relationships between FSH receptor, type 1 insulin-like growth factor receptor, and aromatase expression during FSH-induced differentiation of bovine granulosa cells maintained in serum-free culture. Molecular and Cellular Endocrinology. 203(1-2), 117-27

• View all publications

Current Research

Since 1999 I have utilised my molecular genetics and biochemistry background to develop research interests in the field of reproductive biology. I am particularly interested in widening the current understanding of the major events involved in ovarian folliculogenesis including; oocyte maturation, follicular somatic cell proliferation and differentiation, steroidogenesis, dominant follicle selection and ovulation, and follicle atresia. Currently my work in this field principally focuses on two crucial stimulatory systems. The first of these is the bone morphogenetic protein (BMP) family of ligands and receptors, and their cellular response cascades. These have important roles during follicular development and oocyte maturation. In particular the BMP receptor type 1B (BMPR1B) appears to have great functional significance. A naturally occurring mutation in this gene designated 'FecB' has been demonstrated to increase fecundity in a herd of merino sheep. I am currently investigating the molecular basis for this phenomenon utilising a number of different approaches, involving 'knock-out' systems and 'functional studies'. It is expected that this will also lead to a better understanding of the normal cellular responses to BMP stimulation. The second stimulatory system that I am greatly interested in is hypoxia and its roles in developing antral follicles. It is now well documented that hypoxic conditions are an essential prerequisite of normal antral follicle development and may be crucial to ovulation. However the underlying molecular bases of the cellular responses to hypoxia remain poorly understood. I have modified a specialised cell culture system for studying physiological hypoxia in follicular somatic cell populations.

• NICKLIN, L.T, ROBINSON, R.S, MARSTERS, P, CAMPBELL, B.K, MANN, G.E. and HUNTER, M.G., 2007. Leptin in the bovine corpus luteum: Receptor expression and effects on progesterone production Molecular Reproduction and Development. 74(6), 724-729
• NICKLIN,LT, ROBINSON,RS, MARSTERS,P, CAMPBELL, BK, MANN, GE and HUNTER,MG, 2006. Leptin in the bovine corpus luteum: Receptor expression and effects on progesterone production. Molecular Reproduction and Development. 74(6), 724-9
• KENDALL, N R, MARSTERS, P, GUO, L, SCARAMUZZI, R J and CAMPBELL, B K, 2006. Effect of copper and thiomolybdates on bovine theca cell differentiation in vitro. Journal of Endocrinology. 189(3), 455-63
• MARSTERS, P., DHAWANBAJAJ, A., HARRIS, C., WEISZ, N., CAMPBELL, B.K., CAMPBELL, B.K. and BROUGHTON PIPKIN,F, 2005. Components of the renin-angiotensin system (RAS) are present in the bovine pre-implantation embryo. (Abstract) Journal of The Society for Gynaecological Investigation. 12 Suppl,((2)), 105A
• MARSTERS, P, KENDALL, N.R and CAMPBELL, B.K, 2003. Temporal relationships between FSH receptor, type 1 insulin-like growth factor receptor, and aromatase expression during FSH-induced differentiation of bovine granulosa cells maintained in serum-free culture. Molecular and Cellular Endocrinology. 203(1-2), 117-27
• CAMPBELL, B.K., SOUZA, C., GONG, J., WEBB, R., KENDALL, N., MARSTERS, P., ROBINSON, G., MITCHELL, A., TELFER, E.E. and BAIRD, D.T., 2003. Review: Domestic ruminants as models for the elucidation of the mechanisms controlling ovarian follicle development in humans. Reproduction. Supplement. 61, 429-443
• KENDALL, N. R., MARSTERS, P., SCARAMUZZI, R. J. and CAMPBELL, B. K., 2003. Expression of lysyl oxidase and effect of copper chloride and ammonium tetrathiomolybdate on bovine ovarian follicle granulosa cells cultured in serum-free media Reproduction. 125(5), 657-665
• MORGAN, K., MARSTERS, P., MORLEY, S., VAN GENT, D., HEJAZI, A., BACKX, M., THORPE, E.R.K. and KALSHEKER, N., 2002. Oncostatin M induced α₁-antitrypsin (AAT) gene expression in Hep G2 cells is mediated by a 3' enhancer Biochemical Journal. 365(2), 555-560
• TILLEY, L., MORGAN, K., GRAINGER, J., MARSTERS, P., MORGAN, L., LOWE, J., XUEREB, J., WISCHIK, C., HARRINGTON, C. and KALSHEKER, N., 1999. Evaluation of polymorphisms in the presenilin-1 gene and the butyrylcholinesterase gene as risk factors in sporadic Alzheimer's disease European Journal of Human Genetics. VOL 7(NUMBER 6), 659-663
• MORGAN, K., SCOBIE, G., MARSTERS, P. and KALSHEKER, N. A., 1997. Mutation in an à~1-antitrypsin enhancer results in an interleukin-6 deficient acute-phase response due to loss of cooperativity between transcription factors BBA - Biomembranes. VOL 1362(NUMBER 1), 67-76