Sue Fox

Contact

• workRoom S/D 2106 D Floor South Block, Queens Medical Centre, Nottingham NG7 2UH
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 823 1018
• fax0115 823 1017
• sue.fox@nottingham.ac.uk

Expertise Summary

Research skills associated with the assessment of platelet function in relation to studies of Thrombosis and Haemostasis including platelet aggregometry, HPLC measurement of eicosanoids. Advanced knowledge of flow cytometry research associated with thrombosis and haemostasis including assessment of activation markers on blood cells

Managerial skills related to the strategic planning, management and administration of Cardiovascular Medicine. Financial management of divisional budgets, research grants and contracts including the preparation of financial reports for both day-to-day operations and forward business planning.

Research Summary

Development of novel technology to enable remote assessment of platelet function in blood by flow cytometry. Use of this technology for the evaluation of anti-platelet therapies in patients and… read more

Recent Publications

• IYÚ, DAVID, GLENN, JACKIE R, WHITE, ANN E, FOX, SUE C and HEPTINSTALL, STAN, 2011. Adenosine Derived From ADP Can Contribute to Inhibition of Platelet Aggregation in the Presence of a P2Y12 Antagonist. Arteriosclerosis, thrombosis, and vascular biology. 31(2), 416-422
• IYÚ, DAVID, JÜTTNER, MADLEN, GLENN, JACKIE R, WHITE, ANN E, JOHNSON, ANDREW J, FOX, SUSAN C and HEPTINSTALL, STAN, 2011. PGE(1) and PGE(2) modify platelet function through different prostanoid receptors. Prostaglandins & other lipid mediators. 94(1-2), 9-16
• IYÚ, D, GLENN, J R, WHITE, A E, FOX, S C, VAN GIEZEN, H, NYLANDER, S and HEPTINSTALL, S, 2011. Mode of action of P2Y12 antagonists as inhibitors of platelet function. Thrombosis and Haemostasis. 105(1), 96-106
• IYÚ, DAVID, GLENN, JACKIE R, WHITE, ANN E, JOHNSON, ANDREW J, FOX, SUSAN C and HEPTINSTALL, STAN, 2010. The role of prostanoid receptors in mediating the effects of PGE(2) on human platelet function. Platelets. 21(5), 329-342

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Current Research

Development of novel technology to enable remote assessment of platelet function in blood by flow cytometry. Use of this technology for the evaluation of anti-platelet therapies in patients and volunteers. Techniques for flow cytometric assessment of platelet function include measurement of surface activation markers such as P-selectin, CD63, CD40L, glycoprotein IIb/IIIa, microparticle formation, flow cytometric measurement of platelet aggregation in whole blood Development of cytometric bead assays for measurement of signalling markers such as phosphorylated VASP, and flow cytometric measurement of calcium mobilisation.

Previous studies of the effects of immunosuppressive drugs on platelet function. Modifications of eicosanoid pathways, particularly lipoxygenase pathways during platelet-leukocyte interactions. Catabolic processes involved in ATP/ADP-removal from plasma. Role of purinoreceptors in platelet aggregation and intracellular calcium mobilisation. Development of Flow cytometric techniques for studies of platelets and platelet/leukocyte interactions.

Department Manager with high level skills and experience in flow cytometry, platelet function studies.

Past Research

Previous studies of the effects of immunosuppressive drugs on platelet function. Modifications of eicosanoid pathways, particularly lipoxygenase pathways during platelet-leukocyte interactions. Catabolic processes involved in ATP/ADP-removal from plasma. Role of purinoreceptors in platelet aggregation and intracellular calcium mobilisation. Development of Flow cytometric techniques for studies of platelets and platelet/leukocyte interactions.

Future Research

Recent research focussed on development of remote platelet function testing and patent submissions to facilitate commercialisation for translational research activities.

• IYÚ, DAVID, GLENN, JACKIE R, WHITE, ANN E, FOX, SUE C and HEPTINSTALL, STAN, 2011. Adenosine Derived From ADP Can Contribute to Inhibition of Platelet Aggregation in the Presence of a P2Y12 Antagonist. Arteriosclerosis, thrombosis, and vascular biology. 31(2), 416-422
• IYÚ, DAVID, JÜTTNER, MADLEN, GLENN, JACKIE R, WHITE, ANN E, JOHNSON, ANDREW J, FOX, SUSAN C and HEPTINSTALL, STAN, 2011. PGE(1) and PGE(2) modify platelet function through different prostanoid receptors. Prostaglandins & other lipid mediators. 94(1-2), 9-16
• IYÚ, D, GLENN, J R, WHITE, A E, FOX, S C, VAN GIEZEN, H, NYLANDER, S and HEPTINSTALL, S, 2011. Mode of action of P2Y12 antagonists as inhibitors of platelet function. Thrombosis and Haemostasis. 105(1), 96-106
• IYÚ, DAVID, GLENN, JACKIE R, WHITE, ANN E, JOHNSON, ANDREW J, FOX, SUSAN C and HEPTINSTALL, STAN, 2010. The role of prostanoid receptors in mediating the effects of PGE(2) on human platelet function. Platelets. 21(5), 329-342
• FOX, S C, MAY, J A, SHAH, A, NEUBERT, U and HEPTINSTALL, S, 2009. Measurement of platelet P-selectin for remote testing of platelet function during treatment with clopidogrel and/or aspirin. Platelets. 20(4), 250-9
• HEPTINSTALL, S, FOX, S.C., MAY, J.A., HERMANN, D., STREITER, D. and HARTMAN, D., 2009. EP3 receptor blockade and platelet function in man. J Thromb Haemostas. MO-100
• FOX, S.C., MAY, J.A., SHAH, A., NEUBERT, U. and HEPTINSTALL, S., 2009. Assessment of clopidogrel and aspirin therapy using remote platelet testing. J Thromb Haemostas. 7(Supplement 2), WE-755
• HEPTINSTALL, STAN, ESPINOSA, DAVID IYU, MANOLOPOULOS, PANAGIOTIS, GLENN, JACKIE R, WHITE, ANN E, JOHNSON, ANDREW, DOVLATOVA, NATALIA, FOX, SUE C, MAY, JANE A, HERMANN, DAVID, MAGNUSSON, OLAFUR and STEFAN, 2008. DG-041 inhibits the EP3 prostanoid receptor--a new target for inhibition of platelet function in atherothrombotic disease. Platelets. 19(8), 605-13
• MAY, JANE A, FOX, SUE, GLENN, JACKIE, CRAXFORD, SIMON and HEPTINSTALL, STAN, 2008. Platelet function reduces significantly during the morning. Platelets. 19(7), 556-8
• DOVLATOVA, NATALIA, WIJEYERATNE, YANUSHI D, FOX, SUSAN C, MANOLOPOULOS, PANAGIOTIS, JOHNSON, ANDREW J, WHITE, ANN E, LATIF, M LIAQUE, RALEVIC, VERA and HEPTINSTALL, STANLEY, 2008. Detection of P2Y(14) protein in platelets and investigation of the role of P2Y(14) in platelet function in comparison with the EP(3) receptor. Thrombosis and Haemostasis. 100(2), 261-70
• MANOLOPOULOS, P, GLENN, J R, FOX, S C, MAY, J A, DOVLATOVA, N L, TANG, S-W, THOMAS, N R, RALEVIC, V and HEPTINSTALL, S, 2008. Acyl derivatives of coenzyme A inhibit platelet function via antagonism at P2Y1 and P2Y12 receptors: a new finding that may influence the design of anti-thrombotic agents. Platelets. 19(2), 134-45
• GLENN, J R, WHITE, A E, JOHNSON, A J, FOX, S C, MYERS, B and HEPTINSTALL, S, 2008. Raised levels of CD39 in leucocytosis result in marked inhibition of ADP-induced platelet aggregation via rapid ADP hydrolysis. Platelets. 19(1), 59-69
• HEPTINSTALL, S, MYERS, B, FOX, S.C, GLENN, J.R and JOHNSON, A.J. AND WHITE, A.E., 2007. Raised levels of CD39 in leucocytosis result in marked inhibition of ADP-induced platelet aggregation via rapid ADP hydrolysis. Thrombosis Research. 120(Supplement 2), S153-S154
• HEPTINSTALL, S, MYERS, B, FOX, S.C, GLENN, J.R, JOHNSON, A.J and AND WHITE, A.E., 2007. Raised levels of CD39 in leucocytosis result in marked inhibition of ADP-induced platelet aggregation via rapid ADP hydrolysis. Journal of Thrombosis and Haemostasis: JTH. 5(Supplement 2), P-W-356
• XAVIER, R, WHITE, A, FOX, S, WILCOX, R and AND HEPTINSTALL, S., 2007. Enhanced platelet aggregation and activation under conditions of hypothermia Thrombosis and Haemostasis. 98(6), 1266-1275
• XAVIER, R, WHITE, A, FOX, S and AND HEPTINSTALL, S., 2007. Platelet aggregation is enhanced under conditions of hypothermia. Journal of Thrombosis and Haemostasis: JTH. 5(Supplement 2), P-S-320
• FOX, S.C, MAY, J.A and AND HEPTINSTALL, S., 2007. Measurement of endothelial microparticles in blood is impaired if chylomicrons are present after a fatty meal. Journal of Thrombosis and Haemostasis: JTH. 5(Supplement 2), P-S-526
• MAY, J.A, FOX, S.C, HEPTINSTALL, S and AND KWIK-URIBE, C., 2007. Effects of a flavanol-rich cocoa beverage on platelet and leucocyte function in man. Journal of Thrombosis and Haemostasis: JTH. 5(Supplement 2), P-T-685
• HEPTINSTALL, STAN, MAY, JANE, FOX, SUE, KWIK-URIBE, CATHERINE and ZHAO, LIAN, 2006. Cocoa flavanols and platelet and leukocyte function: recent in vitro and ex vivo studies in healthy adults. Journal of cardiovascular pharmacology. 47 Suppl 2, S197-205; discussion S206-9
• GLENN, JACQUELINE R, WHITE, ANN E, JOHNSON, ANDREW, FOX, SUSAN C, BEHAN, MILES W H, DOLAN, GERRY and HEPTINSTALL, STANLEY, 2005. Leukocyte count and leukocyte ecto-nucleotidase are major determinants of the effects of adenosine triphosphate and adenosine diphosphate on platelet aggregation in human blood. Platelets. 16(3-4), 159-70
• BEHAN, M.W.H., FOX, S.C., HEPTINSTALL, S. and STOREY, R.F., 2005. Inhibitory effects of P2Y12 receptor antagonists on TRAP-induced platelet aggregation, procoagulant activity, microparticle formation and intracellular calcium responses in patients with acute coronary syndromes Platelets. 16(2), 73-80
• HEPTINSTALL,S., TANG,S., MANOLOPOULOS,P., FOX,S., MAY,J., GLENN,J. and RALEVIC,V., 2005. Derivatives of coenzymes A inhibit platelet aggregation via efects at P2Y1 and P2Y12 receptors. In: 20th Congress of the International Society on Thrombosis & Haemostasis. OR334
• FOX, S.C., MANOLOPOULOS, P., MAY, J.A. and HEPTINSTALL, S., 2005. Platelet aggregation, microparticle formation and platelet-leukocyte conjugate formation induced by combinations of 5-HT and epinephrine are inhibited by Sarpogrelate and BP-984 In: International Society Thrombosis & Haemostasis, Sydney, Australia. PO2149
• MANOLOPOULOS, P., FOX, S.C. and HEPTINSTALL, S., 2005. Involvement of P2Y1 and P2Y12 receptors in platelet responses to adenosine diphosphate and thrombin receptor activating peptide. In: International Society of Thrombosis & Haemostasis, Sydney 2005. PO1498
• GLENN, J.R., WHITE, A.E., JOHNSON, A., FOX, S. and BEHAN, M.W., 2005. Raised blood leukocyte counts markedly alter platelet aggregation extent induced by ADP and ATP via CD39. In: International Society of Thrombosis and Haemostasis, Sydney Aug 2005. PO942
• FOX, S.C., BEHAN, M.W.H and HEPTINSTALL, S., 2004. Inhibition of ADP-induced intracellular Ca²⁺ responses and platelet aggregation by the P2Y₁₂ receptor antagonists AR-C69931MX and clopidogrel is enhanced by prostaglandin E₁ Cell Calcium. 35(1), 39-46
• FOX, S.C., SASAE, R., JANSON, S., MAY, J.A. and HEPTINSTALL, S., 2004. Quantitation of platelet aggregation and microaggregate formation in whole blood by flow cytometry. Platelets. 15(2), 85-93
• FOX SC, MAY JA, MANOLOPOULOS P, HEPTINSTALL S, 2004. P2Y1 and P2Y12 purinergic receptor involvement in platelet responses induced by collagen and TRAP In: Platelets. 364
• FOX SC, MAY JA, MANOLOPOULOS P, HEPTINSTALL S, 2004. P2Y1 and P2Y12 purinergic receptor involvement in platelet responses induced by collagen and TRAP In: Platelets. 364
• FOX SC, SIEBERT D, MCMAHON A, MAY J, SPANGENBERG P, HEPTINSTALL S, 2004. Inhibitory effect of physical exercise on platelet aggregation in whole blood may be through In: Platelets. 490
• HEPTINSTALL S, TANG SW, MANOLOPOULOS P, FOX SC, MAY J, GLENN J, RALEVIC V., 2004. N0204-003 inhibits ADP-induced platelet function via antagonism at P2Y1 and In: Platelets. 493
• FOX SC, MANOLOPOULOS P, MAY J, HEPTINSTALL S, 2004. Studies on the effects of sarpogrelate and its active metabolite BP-984 on 5-HT-induced platelet activation In: Platelets. 490
• MANOLOPOULOS P, FOX SC, HEPTINSTALL S., 2004. Involvement of P2Y1 and P2Y12 purinergic receptors in platelet responses to the combination of Adenosine Diphosphate and Thrombin Receptor Activating Peptide In: Platelets. 502
• FOX, S.C., JUDGE, H.M., ALLEN, B.R. and HEPTINSTALL, S., 2002. Platelet aggregation and intracellular calcium mobilisation responses are enhanced by cyclosporin A but not by pimecrolimus (SDZ ASM 981) Platelets. 13(4), 213-218
• HEPTINSTALL, S, WHITE, A, EDWARDS, N, PASCOE, J, SANDERSON, H M, FOX, S C and HENDERSON, R A, 1998. Differential effects of three radiographic contrast media on platelet aggregation and degranulation: implications for clinical practice? British Journal of Haematology. 103(4), 1023-30
• LOUDEN, K A, BROUGHTON PIPKIN, F, HEPTINSTALL, S, FOX, S C, TUOHY, P, O'CALLAGHAN, C, MITCHELL, J R and SYMONDS, E M, 1994. Neonatal platelet reactivity and serum thromboxane B2 production in whole blood: the effect of maternal low dose aspirin. British Journal of Obstetrics and Gynaecology. 101(3), 203-8
• LOUDEN, K A, BROUGHTON PIPKIN, F, HEPTINSTALL, S, FOX, S C, MITCHELL, J R and SYMONDS, E M, 1991. Platelet reactivity and serum thromboxane B2 production in whole blood in gestational hypertension and pre-eclampsia. British Journal of Obstetrics and Gynaecology. 98(12), 1239-44
• LOUDEN, K A, BROUGHTON PIPKIN, F, HEPTINSTALL, S, FOX, S C, MITCHELL, J R and SYMONDS, E M, 1990. A longitudinal study of platelet behaviour and thromboxane production in whole blood in normal pregnancy and the puerperium. British Journal of Obstetrics and Gynaecology. 97(12), 1108-14
• HEPTINSTALL, S and FOX, S C, 1983. Human blood platelet behaviour after inhibition of thromboxane synthetase. British Journal of Clinical Pharmacology. 15 Suppl 1, 31S-37S
• FOX, S C, BURGESS-WILSON, M, HEPTINSTALL, S and MITCHELL, J R, 1982. Platelet aggregation in whole blood determined using the Ultra-Flo 100 Platelet Counter. Thrombosis and Haemostasis. 48(3), 327-9