Tim Harrison

Contact

• workRoom B23 Clinical Sciences Building
  Nottingham City Hospital
  Hucknall Road
  Nottingham
  NG5 1PB
  UK
• work01158231714
• tim.harrison@nottingham.ac.uk

Research Summary

We have explored the therapeutic benefit of increasing the dose of inhaled steroids to prevent the development of asthma exacerbations.

We are currently exploring the mechanisms for therapy resistant asthma and looking at new therapeutic options for these patients

Recent Publications

• BATEMAN ED, HARRISON TW, QUIRCE S, REDDEL HK, BUHL R, HUMBERT M, JENKINS CR, PETERSON S, OSTLUND O, O'BYRNE PM, SEARS MR and ERIKSSON GS, 2011. Overall Asthma Control Achieved With Budesonide/Formoterol Maintenance And Reliever Therapy For Patients On Different Treatment Steps. Respiratory Research. 12, 38
• REDDEL, HK, JENKINS, C, QUIRCE, S, SEARS, MR, BATEMAN, ED, O'BYRNE, PM, HUMBERT, M, BUHL, R, HARRISON, T, BRUSSELLE, GG, THOREN, A, SJOBRING, U, PETERSON, S, OSTLUND, O and ERIKSSON, GS, 2011. Effect Of Different Asthma Treatments On Risk Of Cold-Related Exacerbations European Respiratory Journal. 38(3), 584-593
• HODGSON, DAVID, MORTIMER, KEVIN and HARRISON, TIM, 2010. Budesonide/formoterol in the treatment of asthma. Expert review of respiratory medicine. 4(5), 557-66
• O'BYRNE, P M, REDDEL, H K, ERIKSSON, G, OSTLUND, O, PETERSON, S, SEARS, M R, JENKINS, C, HUMBERT, M, BUHL, R, HARRISON, T W, QUIRCE, S and BATEMAN, E D, 2010. Measuring asthma control: a comparison of three classification systems. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology.

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Past Research

We have explored the absorption and systemic effects of inhaled steroids in asthma and COPD and explored the effect of lung function.

Future Research

We are now able to evaluate airway inflammation using multi-flow exhaled NO meters, induced sputum and various airway challenges. research exploring asthma phenotypes and the development of the new treatments are of interest.

Airway phenotyping includes human airway smooth muscle and epithelial cell culture for in-vitro work.

• BATEMAN ED, HARRISON TW, QUIRCE S, REDDEL HK, BUHL R, HUMBERT M, JENKINS CR, PETERSON S, OSTLUND O, O'BYRNE PM, SEARS MR and ERIKSSON GS, 2011. Overall Asthma Control Achieved With Budesonide/Formoterol Maintenance And Reliever Therapy For Patients On Different Treatment Steps. Respiratory Research. 12, 38
• REDDEL, HK, JENKINS, C, QUIRCE, S, SEARS, MR, BATEMAN, ED, O'BYRNE, PM, HUMBERT, M, BUHL, R, HARRISON, T, BRUSSELLE, GG, THOREN, A, SJOBRING, U, PETERSON, S, OSTLUND, O and ERIKSSON, GS, 2011. Effect Of Different Asthma Treatments On Risk Of Cold-Related Exacerbations European Respiratory Journal. 38(3), 584-593
• HODGSON, DAVID, MORTIMER, KEVIN and HARRISON, TIM, 2010. Budesonide/formoterol in the treatment of asthma. Expert review of respiratory medicine. 4(5), 557-66
• O'BYRNE, P M, REDDEL, H K, ERIKSSON, G, OSTLUND, O, PETERSON, S, SEARS, M R, JENKINS, C, HUMBERT, M, BUHL, R, HARRISON, T W, QUIRCE, S and BATEMAN, E D, 2010. Measuring asthma control: a comparison of three classification systems. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology.
• BATEMAN, ERIC D, REDDEL, HELEN K, ERIKSSON, GÖRAN, PETERSON, STEFAN, OSTLUND, OLLIE, SEARS, MALCOLM R, JENKINS, CHRISTINE, HUMBERT, MARC, BUHL, ROLAND, HARRISON, TIM W, QUIRCE, SANTIAGO and O'BYRNE,, 2010. Overall asthma control: the relationship between current control and future risk. Journal of Allergy and Clinical Immunology. 125(3), 600-8, 608.e1-608.e6
• EDWARDS, S J, VON MALTZAHN, R, NAYA, I P and HARRISON, T, 2010. Budesonide/formoterol for maintenance and reliever therapy of asthma: a meta analysis of randomised controlled trials. International journal of clinical practice. 64(5), 619-27
• COOPER, S., OBORNE, J., HARRISON, T. and TATTERSFIELD, A., 2009. Effect of mouth taping at night on asthma control – a randomised single-blind crossover study Respiratory Medicine. 103(6), 813-819
• DALBY,, POWLANOWSKI,, LARSSON,, BORGSTROM,, EDSBACKER, and HARRISON,, 2009. The bioavailability and airway clearance of the steroid component of budesonide/formoterol and salmeterol/fluticasone after inhaled administration in patients with COPD and healthy subjects: A randomized controlled trial. Respiratory Research. 10(1), 104
• OBORNE, JANET, MORTIMER, KEVIN, HUBBARD, RICHARD B, TATTERSFIELD, ANNE E and HARRISON, TIM W, 2009. Quadrupling the dose of inhaled corticosteroid to prevent asthma exacerbations: a randomized, double-blind, placebo-controlled, parallel-group clinical trial. American journal of respiratory and critical care medicine. 180(7), 598-602
• SOVANI, M.P., WHALE, C.I., OBORNE, J., COOPER, S., MORTIMER, K., EKSTRÖM, T., TATTERSFIELD, A.E. and HARRISON, T.W., 2008. Poor adherence with inhaled corticosteroids for asthma: can using a single inhaler containing budesonide and formoterol help? British Journal of General Practice. 58(546), 37-43
• WHALE, CHRISTOPHER I, SOVANI, MILIND P, MORTIMER, KEVIN J, HARRISON, TIMOTHY W and TATTERSFIELD, ANNE E, 2008. Systemic and bronchodilator effects of inhaled rac-formoterol in subjects with chronic obstructive pulmonary disease: a dose-response study. British journal of clinical pharmacology. 65(6), 841-7
• MORTIMER, KEVIN J, TATTERSFIELD, ANNE E, TANG, YUFEI, WU, KAI, LEWIS, SARAH, HOCHHAUS, GUNTHER and HARRISON, TIM W, 2007. Plasma concentrations of fluticasone propionate and budesonide following inhalation: effect of induced bronchoconstriction. British Journal of Clinical Pharmacology. 64(4), 439-44
• WHALE, C.I., SOVANI, M.P., MORTIMER, K., OBORNE, J., COOPER, S., HARRISON, T. W. and TATTERSFIELD, A.E., 2006. Effects of rac-albuterol on arterial blood gases in patients with stable hypercapnic chronic obstructive pulmonary disease. British Journal of Clinical Pharmacology. 62(2), 153-7
• MORTIMER, K. J., TATA, L. J., SMITH, C. J. P., WEST, J., HARRISON, T. W., TATTERSFIELD, A. E. and HUBBARD, R. B., 2006. Oral and inhaled corticosteroids and adrenal insufficiency: a case-control study. Thorax. 61(5), 405-8
• MORTIMER, KEVIN J, HARRISON, TIM W, TANG, YUFEI, WU, KAI, LEWIS, SARAH, SAHASRANAMAN, SRIKUMAR, HOCHHAUS, GUNTHER and TATTERSFIELD, ANNE E, 2006. Plasma concentrations of inhaled corticosteroids in relation to airflow obstruction in asthma. British Journal of Clinical Pharmacology. 62(4), 412-9
• TATTERSFIELD, ANNE E and HARRISON, TIMOTHY W, 2006. beta-Adrenoceptor polymorphisms: focus moves to long-acting beta-agonists. American Journal of Respiratory and Critical Care Medicine. 173(5), 473-4
• HARRISON, T.W., OBORNE, J., NEWTON, S. and TATTERSFIELD, A.E., 2004. Doubling the dose of inhaled corticosteroid to prevent asthma exacerbations: randomised controlled trial. Lancet. 363(9405), 271-275
• PHILLIPS, K., OBORNE, J., HARRISON, T. W. and TATTERSFIELD, A. E., 2004. Use of sequential quadrupling dose regimens to study efficacy of inhaled corticosteroids in asthma Thorax. 59(1), 21-25
• PHILLIPS, K., OBORNE, J., LEWIS, S., HARRISON, T.W. and TATTERSFIELD, A.E., 2004. Time course of action of two inhaled corticosteroids, fluticasone propionate and budesonide Thorax. 59(1), 26-30
• TATTERSFIELD, A. E., HARRISON, T. W., HUBBARD, R. B. and MORTIMER, K., 2004. Safety of Inhaled Corticosteroids PROCEEDINGS- AMERICAN THORACIC SOCIETY. VOL 1(NUMB 3), 171-175
• HARRISON, T.W. and TATTERSFIELD, A.E., 2003. Plasma concentrations of fluticasone propionate and budesonide following inhalation from dry powder inhalers by healthy and asthmatic subjects Thorax. 58(3), 258-60
• TATA,L., WEST,J., HARRISON,T., FARRINGTON,P., SMITH,C. and HUBBARD,R., 2003. Does influenza vaccination increase consultations, corticosteroid prescriptions, or exacerbations in subjects with asthma or chronic obstructive pulmonary disease? Thorax. 58(10), 835-39
• TATTERSFIELD, A.E. and HARRISON, T.W., 2003. Management and treatment of asthma. In: Respiratory Medicine 2.
• TATTERSFIELD, A.E. and HARRISON, T.W., 2003. Low-dose budesonide for asthma Lancet. 361, 1066-7
• WALSH, L. J., LEWIS, S. A., WONG, C. A., COOPER, S., OBORNE, J., CAWTE, S. A., HARRISON, T., GREEN, D. J., PRINGLE, M., HUBBARD, R. and TATTERSFIELD, A.E, 2002. The impact of oral corticosteroid use on bone Mineral density and vertebral fracture American Journal of Respiratory and Critical Care Medicine. 166(5), 691-695
• HUBBARD, R.B., SMITH, C.J.P., SMEETH, L., HARRISON, T.W. and TATTERSFIELD, A.E., 2002. Inhaled corticosteroids and hip fracture: a population-based case-control study American Journal of Respiratory and Critical Care Medicine. 166(12), 1563-1566
• HARRISON, T.W., WISNIEWSKI, A., HONOUR, J. and TATTERSFIELD, A. E., 2001. Comparison of the systemic effects of fluticasone propionate and budesonide given by dry powder inhaler in healthy and asthmatic subjects. Thorax. 56(3), 186-91
• TATTERSFIELD, A.E. and HARRISON, T.W., 2001. Exacerbations of asthma - still room for improvement Lancet. 358, 599-601
• TATTERSFIELD, A.E. and HARRISON, T.W., 2001. Inhaled steroids for COPD? Thorax. 56(Suppl 2), ii2-6
• HARRISON, T.W. and TATTERSFIELD, A.E., 2001. Asthma. In: Respiratory Medicine 81-106
• HARRISON, T.W., 2001. Systemic availability of inhaled budesonide and fluticasone propionate: healthy versus asthmatic lungs BioDrugs. 15(6), 405-11
• HARRISON, T.W. and TATTERSFIELD, A.E., 1999. Step three of the asthma guidelines Thorax. 54, 753-754
• HARRISON, T.W., TATTERSFIELD, A.E. and BENNETT, J.A., 1999. The relative contribution to systemic effects of the swallowed fraction of an inhaled dose of salmeterol European Respiratory Journal. 13, 445-448
• OBORNE, J., WILDING, P.J. and HARRISON, T.W., 1999. Randomised placebo controlled trial of β-agonist dose reduction in asthma Thorax. 54, 98-102
• HARRISON, T W, OBORNE, J, WILDING, P J and TATTERSFIELD, A E, 1999. Randomised placebo controlled trial of beta agonist dose reduction in asthma. Thorax. 54(2), 98-102
• BENNETT, J A, HARRISON, T W and TATTERSFIELD, A E, 1999. The contribution of the swallowed fraction of an inhaled dose of salmeterol to it systemic effects. European Respiratory Journal. 13(2), 445-8
• HARRISON, T W and TATTERSFIELD, A E, 1998. Effect of single doses of inhaled lignocaine on FEV1 and bronchial reactivity in asthma. Respiratory Medicine. 92(12), 1359-63
• HARRISON, T.W., 1996. A rare cause of superior vena cava obstruction (Grand Round) British Medical Journal. 313, 1324-1326