William Whitehouse

Contact

• workRoom Child Health E Floor East Block
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 924 63328
• fax0115 82 30626
• william.whitehouse@nottingham.ac.uk

Biography

As well as developing and running trials, Dr Whitehouse is active in other areas of clinical research.

Recent projects have included trials of antiepileptic treatments, migraine treatments, sleep disorders treatments, the development of associated movements in normal children, the development of a new autonomic function assessment protocol for children. He is also active in clinical audit and service evaluation, frequently working on projects with medical students, e.g. in thier honours year or special study modules. He has developed the role of consumer involvement, in collaboration with the Medicines for Children Reserach Network (MCRN) East, engaging patient groups and thier families, and school children, in focus groups and questionnaires to inform all stages of study design.

Dr Whitehouse is an enthusiastic collaborator and likes working in multidisciplinary teams.

Teaching Summary

I have just completed my term as co-ordinator for Child Health for the Honours Year Course in Clinical Sciences (2005-2011).

I have led the development and deployment of the Developmental Neurosciences taught course (A13 DNS) for which I remain the Module Convenor (2005-).

I regularly supervise and examine Honours Year student projects in Clinical Sciences (2001-).

I regulary teach and examine Paediatrics & Child Health medical students (2001-).

I regularly teach and examine for the University of London MSc in Epileptology (2005-).

I regularly teach the national Paediatric Epilepsy Training (PET) courses at levels 1, 2, 3, organised by the British Paediatric Neurology Association (2005-).

I occassionally teach and supervise or examine MSc, MD, PhD students, and medical postgraduates for MRCPCH, and give various invited lectures.

Research Summary

CI RCT preventing migraine in children and young people (P3MC) closing June 2011.

PI RCT drug treatment of Infantile Spasms (ICISS).

PI cohort study of acute inflamatory demyelination in children (PUDDLS).

Recent Publications

• MILLS, J K A, RUSLAN, N.E., LEWIS, T.G., MUGHAL, K, ALI, I, UGAR, A, WASSMER, E, SIDDIQUA, A, GUPTA, R, MORDEKAR, S.R., SHARMA, R, SASIDHARAN, L and WHITEHOUSE, W.P., 2011. Retention rate of Clobazam, Topiramate and Lamotrigine in children with intractable epilepsies at 1 year. Seizure : the journal of the British Epilepsy Association. 20(5), 402-5
• WOLFF, A, BROWNE, J and WHITEHOUSE, W P, 2011. Personal resuscitation plans and end of life planning for children with disability and life-limiting/life-threatening conditions. Archives of disease in childhood. Education and practice edition. 96(2), 42-8
• DIETZ, SANNE, MURFITT, JULIA, FLORENCE, LYNDSEY, THAKKER, PRADIP and WHITEHOUSE, WILLIAM P, 2011. Head-up tilt testing in children and young people: A retrospective observational study. Journal of paediatrics and child health. 47(5), 292-8
• WHITEHOUSE, WP, 2011. Metabolic Testing In Children With Cerebral Palsy: Yield Could Be Up To 20% Developmental Medicine And Child Neurology. 53(12), 1160-1160

• View all publications

Past Research

PI RCT Melatonin for children with neurodisabilities and dosordered sleep (MENDS).

PI RCT Vagal Nerve Stimulation (VNS) for intractible epilepsies.

PI RCT emergency treatment of prolonged seizures in children and young people in the Emergency Department.

CI pilot RCT home administration of emergency treatment of prolonged seizures in children and young people.

PI RCT treatment of infantile spasms.

CI Assessment of associated movements (motor development) in children and Fog's test.

CI Development of a protocol for the assessment of autonomic function in children and young people.

Future Research

RCT preventing migraine in children and young people.

RCT emergency treatment of prolonged seizures in children and young people.

Systematic study of antiepileptic drug adverse events in children and young people

Phase 1 trial of novel treatment for Lafora Body Disease.

RCT enteral treatment of increased tone / spasticity in children and young people.

Validation study of AT Neurological Examination Scale Toolkit (AT NEST).

• MILLS, J K A, RUSLAN, N.E., LEWIS, T.G., MUGHAL, K, ALI, I, UGAR, A, WASSMER, E, SIDDIQUA, A, GUPTA, R, MORDEKAR, S.R., SHARMA, R, SASIDHARAN, L and WHITEHOUSE, W.P., 2011. Retention rate of Clobazam, Topiramate and Lamotrigine in children with intractable epilepsies at 1 year. Seizure : the journal of the British Epilepsy Association. 20(5), 402-5
• WOLFF, A, BROWNE, J and WHITEHOUSE, W P, 2011. Personal resuscitation plans and end of life planning for children with disability and life-limiting/life-threatening conditions. Archives of disease in childhood. Education and practice edition. 96(2), 42-8
• DIETZ, SANNE, MURFITT, JULIA, FLORENCE, LYNDSEY, THAKKER, PRADIP and WHITEHOUSE, WILLIAM P, 2011. Head-up tilt testing in children and young people: A retrospective observational study. Journal of paediatrics and child health. 47(5), 292-8
• WHITEHOUSE, WP, 2011. Metabolic Testing In Children With Cerebral Palsy: Yield Could Be Up To 20% Developmental Medicine And Child Neurology. 53(12), 1160-1160
• J.K.A. MILLS, N.E. RUSLAN, T.G. LEWIS, K. MUGHAL, I. ALI, A. UGAR, E. WASSMER, A. SIDDIQUA, R. GUPTA, S.R. MORDEKAR, R. SHARMA, L. SASIDHARAN and W.P. WHITEHOUSE, 2011. Retention rate of Gabapentin in children with intractable epilepsies at 1 year Seizure. 21, 28-31
• CHANDRATRE, SALEEL R., GODDARD, TONY, MORTON, RICHARD and WHITEHOUSE, WILLIAM P., 2011. Intra-arterial thrombolysis in a child with acute basilar artery occlusion Journal of Pediatric Neurology. 9, 391-396
• WHITEHOUSE, WILLIAM P, 2011. Metabolic testing in children with cerebral palsy: yield could be up to 20%: Letter to the Editor Developmental Medicine & Child Neurology. The Author. 1160
• WOLFF, A, BROWNE, J and WHITEHOUSE, W P, 2011. Personal resuscitation plans and end of life planning for children with disability and life-limiting/life-threatening conditions Arch Dis Child Educ Pract Ed. 96, 42-48
• DIETZ, SANNE, MURFITT, JULIA, FLORENCE, LYNDSEY, THAKKER, PRADIP and WHITEHOUSE, WILLIAM P, 2011. Head-up tilt testing in children and young people: A retrospective observational study Journal of Paediatrics and Child Health. 47, 292-298
• ABSOUD, MICHAEL, CUMMINS, CAROL, CHONG, WUI K, DEGOEDE, CHRISTIAN, FOSTER, KATHARINE, GUNNY, ROXANNA, HEMINGWAY, CHERYL, JARDINE, PHILIP, KNEEN, RACHEL, LIKEMAN, MARCUS, LIM, MING J, PIKE, MIKE, SIBTAIN, NAOMI, WHITEHOUSE, WILLIAM P and WASSMER, EVANGELINE, 2011. Paediatric UK Demyelinating Disease Longitudinal Study (PUDDLS) BMC Pediatrics. 11, 68
• WHITEHOUSE, W.P., 2010. Reflex anoxic seizures. VOL 8(NUMB 1), 51-54
• HUSSAIN, NAHIN, DHANARASS, MUTHU and WHITEHOUSE, WILLIAM, 2010. Frey's syndrome: a masquerader of food allergy. Postgraduate medical journal. 86(1011), 62
• MARTIN, K, BATES, G and WHITEHOUSE, W P, 2010. Transient loss of consciousness and syncope in children and young people: what you need to know. Archives of disease in childhood. Education and practice edition. 95(3), 66-72
• WILLIAM P WHITEHOUSE, 2010. Breath holding spells Journal of Pediatric Neurology. 8, 49-50
• AHMED, M., MARTINEZ, A., CAHILL, D., CHONG, K. and WHITEHOUSE, W., 2010. When to image neurologically normal children with headaches: development of a decision rule ACTA PAEDIATRICA. VOL 99(NUMBER 6), 940-943
• WITHAM, D, SILCOCKS, P, WHITEHOUSE, W, HODGSON, H and SAMMONS, H, 2009. An example of problems that arise from clinical trials and how to avoid them The Pharmaceutical Journal. 283, 129-130
• DOWLEY, ANDREW C, WHITEHOUSE, WILLIAM P, MASON, STEVE M, COPE, YVONNE, GRANT, JUDITH and GIBBIN, KEVIN P, 2009. Auditory neuropathy: unexpectedly common in a screened newborn population. Developmental Medicine and Child Neurology. 51(8), 642-6
• MORE, A, JASPAN, T and WHITEHOUSE, W P, 2009. MRI elucidates unusual cranial mass. Archives of Disease in Childhood. 94(5), 347
• FAWKE, JOE, WHITEHOUSE, W P and KUDUMULA, VIKRAM, 2008. Monitoring of newborn weight, breast feeding and severe neurological sequelae secondary to dehydration. Archives of Disease in Childhood. 93(3), 264-5
• MORDEKAR, S.R., RITTEY, C.D., JASPAN, T., CONNOLLY, D.J. and WHITEHOUSE, W.P., 2008. Glioblastoma multiforme incorrectly diagnosed as ADEM in children Journal of Paediatric Neurology. 6, 53-56 (In Press.)
• WASSMER, E. and WHITEHOUSE, W.P., 2008. Simultaneous Peripheral and Central Demyelination Journal of Child Neurology. 23(12), 1495-1496
• KIRKHAM, FENELLA J, NEWTON, CHARLES R J C and WHITEHOUSE, WILLIAM, 2008. Paediatric coma scales. Developmental Medicine and Child Neurology. 50(4), 267-74
• PEAKE, D, MORDEKAR, S, GOSALAKKAL, J, MUKHTYAR, B, BUCH, S, CRANE, J, WHEWAY, R, RITTEY, C, DONNELLY, J, WHITEHOUSE, W P and PHILIP, S, 2007. Retention rate of Levetiracetam in children with intractable epilepsy at 1 year. Seizure. 16(2), 185-9
• HUSSAIN, N. and WHITEHOUSE, W.P., 2007. Transient loss of consiousness and syncope Paediatric Epilepsy. 2(3), 3-11
• FREW, E. J., SANDERCOCK, J., WHITEHOUSE, W. P. and BRYAN, S., 2007. The cost-effectiveness of newer drugs as add-on therapy for children with focal epilepsies SEIZURE. VOL 16(NUMBER 2), 99-112
• BROWN, R M, HEAD, R A, MORRIS, A A M, RAIMAN, J A J, WALTER, J H, WHITEHOUSE, W P and BROWN, G K, 2006. Pyruvate dehydrogenase E3 binding protein (protein X) deficiency. Developmental Medicine and Child Neurology. 48(9), 756-60
• HUSSAIN, N, REGAN, E, GOSALAKKAL, J and WHITEHOUSE, W P, 2006. Use of buccal midazolam in children. Archives of Disease in Childhood. 91(12), 1041-2
• WASSMER, E. and WHITEHOUSE, W. P., 2006. Melatonin and sleep in children with neurodevelopmental disabilities and sleep disorders Current Paediatrics. VOL 16(NUMBER 2), 132-138
• JATAVALLABHULA, N S, ARMSTRONG, J, SGOUROS, S and WHITEHOUSE, W, 2006. Spontaneous resolution of isolated Chiari I malformation. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. 22(2), 201-3
• AGRAWAL, S. and WHITEHOUSE, W.P., 2006. Evaluation of the first episode of a possible fit in a child Current Paediatrics. VOL 16(NUMBER 5), 322-327
• MORRISON,, GIBBONS, and WHITEHOUSE,, 2006. High-dose midazolam therapy for refractory status epilepticus in children. 32(12), 2070-2076
• MCINTYRE, J., ROBERTSON, S., NORRIS, E., APPLETON, R., WHITEHOUSE, W.P., PHILLIPS, B., MARTLAND, T., BERRY, K., COLLIER, J., SMITH, S. and CHOONARA, I., 2005. Safety and efficacy of buccal midazolam versus rectal diazepam for emergency treatment of seizures in children: a randomised controlled trial Lancet. 366(9481), 205-210
• MAR, S., DUNKLEY, C., AL-ANSARI, I. and WHITEHOUSE, W.P., 2005. Comparison of a dedicated children's seizure clinic to mixed general paediatric clinics Child: Care, Health and Development. 31(5), 597-602
• MORDEKAR, S R, BRADLEY, P J, WHITEHOUSE, W P and GODDARD, A J P, 2005. Occult carotid pseudoaneurysm following streptococcal throat infection. Journal of paediatrics and child health. 41(12), 682-4
• DUNKLEY, C., ALBERT, D., MORRIS, N., WILLIAMS, J. and WHITEHOUSE, W. P., 2005. A population audit of first clinic attendance with suspected epilepsy Seizure. VOL 14(NUMBER 8), 606-610
• GAYATRI,N.A. and WHITEHOUSE,W.P, 2005. Pilot survey of Hasimoto's encephalopathy in children Developmental Medicine and Child Neurology. 47, 556-558
• WHITEHOUSE,W.P, 2005. Diagnosis and management of epilepsies in children and young people - a national clinical guideline.. In: SCOTTISH INTERCOLLEGIATE GUIDELINES NETWORK, ed., Diagnosis and management of epilepsies in children and young people: Scottish Intercollegiate Guidelines Network SIGN. 53
• MORDEKAR, S., JASPAN, T., SHARRARD, M., MORTON, R. and WHITEHOUSE, W. P., 2005. Acute Bilateral Striatal Necrosis with Rotavirus Gastroenteritis and Inborn Metabolic Predisposition Developmental Medicine and Child Neurology. VOL 47(NUMB 6), 415-418
• AHMED, M. A., MARTINEZ, A., MARIAM, S. and WHITEHOUSE, W., 2004. Chvostek's sign and hypocalcaemia in children with seizures Seizure. VOL 13(NUMBER 4), 217-222
• PEAKE, D., WHITEHOUSE, W. P. and PHILIP, S., 2004. The management of Guillain-Barre syndrome Current Paediatrics. VOL 14(NUMBER 3), 252-257
• GUPTE, G., STONEHOUSE, M., WASSMER, E., COAD, N.A.G. and WHITEHOUSE, W.P., 2003. Acute disseminated encephalomyelitis: a review of 18 cases in childhood Journal of Paediatrics and Child Health. 39(5), 336-342
• WASSMER, E., DAVIES, P., WHITEHOUSE, W. P. and GREEN, S. H., 2003. Clinical spectrum associated with cerebellar hypoplasia PEDIATRIC NEUROLOGY. VOL 28(NUMBER 5), 347-351
• JANES, S. E. and WHITEHOUSE, W. P., 2003. Brachial neuritis following infection with Epstein-Barr virus European Journal of Paediatric Neurology. VOL 7(NUMBER 6), 413-415
• DUNKLEY, C., WALDRON, B., AHMAD, N. and WHITEHOUSE, W., 2003. An observational study investigating the health provision for children with epilepsy within secondary schools in the East Midlands, UK Child Care Health and Development. VOL 29(NUMBER 6), 539-544
• ASHTEKAR, C. S., JASPAN, T., THOMAS, D., WESTON, V., GAYATRI, N. A. and WHITEHOUSE, W. P., 2003. Acute Bilateral Thalamic Necrosis in a Child with Mycoplasma Pneumoniae Developmental Medicine and Child Neurology. VOL 45(PART 9), 634-637
• WHITEHOUSE,W.P. and BOULES,G, 2003. Convulsions, epilepsy, syncope and breath-holding. In: BARRETT, T.G. and LANDER, A & DIWAKAR, V, eds., A Paediatric Vade-Mecum Edward Arnold, London. 176-179
• STONEHOUSE, M., GUPTE, G., WASSMER, E. and WHITEHOUSE, W. P., 2003. Acute disseminated encephalomyelitis: recognition in the hands of general paediatricians Archives of Disease in Childhood. VOL 88(NUMB 2), 122-124
• JOHNSON, K., PAGE, A., WILLIAMS, H., WASSEMER, E. and WHITEHOUSE, W., 2002. The Use of Melatonin as an Alternative to Sedation in Uncooperative Children Undergoing an MRI Examination Clinical Radiology. VOL 57(PART 6), 502-506
• ROSS, C., DAVIES, P. and WHITEHOUSE, W., 2002. Melatonin Treatment for Sleep Disorders in Children with Neurodevelopmental Disorders: an Observational Study Developmental Medicine and Child Neurology. VOL 44(PART 5), 339-344
• TASKE, N. L., WILLIAMSON, M. P., MAKOFF, A., BATE, L., CURTIS, D., KERR, M., KJELDSEN, M. J., PANG, K. A., SUNDQVIST, A. and FRIIS, M. L., 2002. Evaluation of the positional candidate gene CHRNA7 at the juvenile myoclonic epilepsy locus (EJM2) on chromosome 15q13-14 Epilepsy Research. VOL 49(NUMBER 2), 157 - 172
• WASSMER, E., WRIGHT, E., RIDEOUT, S. and WHITEHOUSE, W. P., 2002. Idiopathic gait disorder among in-patients with acquired gait disorders admitted to a children's hospital Pediatric Rehabilitation. VOL 5(NUMB 1), 21-28
• ROBINSON, R., TASKE, N., SANDER, T., HEILS, A., WHITEHOUSE, W., GOUTIERES, F., AICARDI, J., LEHESJOKI, A. E., SIREN, A. and LAUE FRIIS, M., 2002. Linkage analysis between childhood absence epilepsy and genes encoding GABAA and GABAB receptors, voltage-dependent calcium channels, and the ECA1 region on chromosome 8q Epilepsy Research. VOL 48(NUMBER 3), 169 - 179
• QURESHI, A, WASSMER, E, DAVIES, P, BERRY, K and WHITEHOUSE, W P, 2002. Comparative audit of intravenous lorazepam and diazepam in the emergency treatment of convulsive status epilepticus in children. Seizure. 11(3), 141-4
• WHITEHOUSE,W.P, 2002. Specific causes of headache. In: ABU-ARAFEH, I, ed., Childhood Headache Mac Keith Press, High Holburn, London, UK. 108-121
• WASSMER, E., QUINN, E., WHITEHOUSE, W. and SERI, S., 2001. Melatonin as a sleep inductor for electroencephalogram recordings in children Clinical Neurophysiology. 112(4), 683-685
• WHITEHOUSE, W., DAVIES, P. and ROSS, C., 2001. Use of melatonin in the management of disordered sleep in children with neuro-disabilities: a prospective audit of outcome Developmental Medicine and Child Neurology. 43(S89), 26
• SINGH, R., ANDERMANN, E., WHITEHOUSE, W. P. A., HARVEY, A. S., KEENE, D. L., SENI, M.-H., CROSSLAND, K. M., ANDERMANN, F., BERKOVIC, S. F. and SCHEFFER, I. E., 2001. Severe Myoclonic Epilepsy of Infancy: Extended Spectrum of GEFS^+? Epilepsia. VOL 42(PART 7), 837-844
• MENAKAYA, J O, WASSMER, E, BRADSHAW, K, SERI, S and WHITEHOUSE, W P, 2001. Idiopathic central pontine myelinolysis in childhood. Developmental Medicine and Child Neurology. 43(10), 697-700
• SPENCER,E., KOUROS,A., WHITEHOUSE,W., ROBINSON,R., CALVER,D., HARRISON,R., MANUCHEHRI,K. and HARDING,G, 2001. Examining visual field defects in the paediatric population exposed to vigabatrin Archives of Disease in Childhood. 84(Suppl I), A45
• WASSMER,E., MCGRATH,G., ROSS,C., MCDONALD,A. and WHITEHOUSE,W, 2001. The nutritional consequences of the ketogenic diet Epilepsia. 42(Suppl.7), 267-268
• WASSMER, E., FOGARTY, M., PAGE, A., JOHNSON, K., QUIN, E., SERI, S. and WHITEHOUSE, W., 2001. `Melatonin as a Sedation Substitute for Diagnostic Procedures: MRI and EEG' Developmental Medicine and Child Neurology. VOL 43(PART 2), 136
• ABBAS,M., POWELL,J., EDWARDS,A., EDWARDS,M., PANDIT,S., SUNGAM-PALIWAL,R. and WHITEHOUSE,W, 2001. A population based time-trend analysis of autistic spectrum disorders in the West Midlands: no evidence for a single cause to account for the rise in incidence Developmental Medicine and Child Neurology. 43(S90), 8-9
• WHITEHOUSE,W.P, 2001. In: MACKWAY-JONES, K, MOLYNEUX, E and PHILLIPS, B & WIETESKA, S, eds., Advanced Paediatric Life Support: the practical approach 3rd. xvi,336
• SPENCER,E., KOUROS,A., WHITEHOUSE,W., ROBINSON,R., CALVER,D., HARRISON,R., MANUCHEHRI,K. and HARDING,G, 2001. Measuring visual field defects in children exposed to vigabatrin Seizure. 10, 389
• CALLAGHAN,M., MORISON,C., SCHWERIN,A., WHITEHOUSE,W. and ABU-ARAFEH,I, 2001. Childhood headache: results of an audit of clinical assessment Developmental Medicine and Child Neurology. 43(S90), 25
• WHITEHOUSE,W., RYLANCE,G., GIBBONS,E. and MORRISON,G, 2001. Treatment of refractory status epilepticus in paediatric intensive care: further experience with intravenous midazolam infusion with a rapid dose escalation in 20 episodes Developmental Medicine and Child Neurology. 43(S90), 35-36
• WASSMER,E., MORRIS,B., FERNANDO,L., RAO,M. and WHITEHOUSE,W, 2001. Intranasal midazolam for treating febrile seizures in children. Buccal midaxolam for childhood seizures at home preferred to rectal diazepam British Medical Journal. 322(Jan 2001), 108
• WASSMER, E., CARTER, P. F. B., QUINN, E., MCLEAN, N., WELSH, G., SERI, S. and WHITEHOUSE, W. P., 2001. Melatonin is Useful for Recording Sleep EEGs: a Prospective Audit of Outcome Developmental Medicine and Child Neurology. VOL 43(PART 11), 735-738
• WASSMER, E., BARRAT, L., GREEN, S. H. and WHITEHOUSE, W., 2001. Siblings with developmental delay, mild spasticity and subcortical cysts: a further leukoencephalopathy? European Journal of Paediatric Neurology. VOL 5(PART 4), 169-174
• POWELL, J E, EDWARDS, A, EDWARDS, M, PANDIT, B S, SUNGUM-PALIWAL, S R and WHITEHOUSE, W, 2000. Changes in the incidence of childhood autism and other autistic spectrum disorders in preschool children from two areas of the West Midlands, UK. Developmental Medicine and Child Neurology. 42(9), 624-8
• ELMSLIE, F V, REES, M, WILLIAMSON, M P, KERR, M, KJELDSEN, M J, PANG, K A, SUNDQVIST, A, FRIIS, M L, CHADWICK, D, RICHENS, A, COVANIS, A, SANTOS, M, ARZIMANOGLOU, A, PANAYIOTOPOULOS, C P, CURTIS, D, WHITEHOUSE, W P and GARDINER, R M, 1997. Genetic mapping of a major susceptibility locus for juvenile myoclonic epilepsy on chromosome 15q. Human Molecular Genetics. 6(8), 1329-34
• TATMAN, A, WARREN, A, WILLIAMS, A, POWELL, J E and WHITEHOUSE, W, 1997. Development of a modified paediatric coma scale in intensive care clinical practice. Archives of Disease in Childhood. 77(6), 519-21
• ELMSLIE, F. V., WILLIAMSON, M. P., REES, M., KERR, M., KJELDSEN, M. J., PANG, K. A., SUNDQVIST, A., FRIIS, M. L., RICHENS, A. and CHADWICK, D., 1996. Linkage Analysis of Juvenile Myoclonic Epilepsy and Microsatellite Loci Spanning 61 cM of Human Chromosome 6p in 19 Nuclear Pedigrees Provides No Evidence for a Susceptibility Locus in This Region American Journal of Human Genetics. VOL 59(NUMBER 3), 653-663
• STEFANO SERI and WILLIAM WHITEHOUSE, Role of Clinical Neurophysiology in the management of children and young people with epilepsies 3-9