School of Veterinary Medicine and Science
   
   
  
 

Duncan Hannant

Professor of Applied Immunology, Faculty of Medicine & Health Sciences

Contact

  • workRoom C17 School of Vet Med and Science, Gateway Building
    Sutton Bonington Campus
    Sutton Bonington
    Leicestershire
    LE12 5RD
    UK
  • work0115 951 6455
  • fax0115 951 6440

Biography

My mainstream research and publications are in the area of immune responses to infection with and vaccination against respiratory viruses in horses, with extended interests in agricultural species and dogs. Understanding the horse's immune responses to natural infection has been critical to the development of new strategies for disease prevention. For example, my group described the locally recirculating mucosal immune system in horses and we exploited this to demonstrate for the first time that intranasal vaccination with inactivated virus and mucosal adjuvants induced extremely effective immunity to re-infection with equine influenza virus. Detailed studies with my colleague Dr Julia Kydd (also at SVMS Nottingham) have uniquely identified cellular immune correlates of protection from alphaherpesviruses in horses. This new information has led to new international collaborations on rational approaches to new vaccine design. Both of these developments have had significant benefits to the health and welfare of horses.

In addition to these research areas, my recent funding has supported the development of immunological reagents specifically for the horse as part of a BBSRC initiative on Combatting Viral Diseases of Livestock (The Immunological Toolbox; http://www.immunologicaltoolbox.co.uk ) .

New funding was gained from the EU, FP7 Programme starting in July 2009 which I coordinated; Novel technologies for Surveillance of Emerging and Re-emerging Infections of Wildlife (Acronym = WildTech). The project addressed the problem of the increasing prevalence of new and re-emerging diseases in wildlife which can affect farm livestock and humans. The objective was to set up a pan-European system for rapid and accurate diagnosis of infectious diseases in wildlife - technology transfer from our research labs and programme to veterinary/wildlife scientists was an important component of the work. As part of our dissemination activities, we held two sponsored sessions at the Global Risk Forum (GRF) One Health Summit in Davos, Switzerland, November 2013. Total budget for the WildTech project was €8.1M, total requested from EU €5.9M, total award to University of Nottingham €1.4M. Co-applicants from Nottingham were Paul Barrow, Lisa Yon, Richard Lea (SVMS) and Susie Boardman (EMZS, Twycross Zoo, Clinical Associate of the School). WildTech has 13 international Partners (including Canada) and approximately 37 Associate and Collaborative Partners from across Europe and beyond, who are closely integrated in to the project. Collaborative links with USA, Russia and the far-East are important components of the programme. For more information go to: www.wildtechproject.com which has links to the current newsletter http://www.wildtechproject.com/wildtech/node/28.

Expertise Summary

Research expertise is in a wide range of laboratory and field investigations of immune responses to infectious viruses in animals. Successful in winning many competitive research awards to fund research and support postgraduate (PhD and MSc) students. Director of studies for 10 successful PhD and 3 MSc students. Approx 20 years experience of managing research groups and active member of senior management/strategic groups. External examiner for taught BSc and MSc courses in Equine and Animal Science at University of Aberystwyth. Regular reviewer of research applications on behalf of the major funding bodies and external PhD examiner for universities of Cambridge, London, Liverpool, Edinburgh.

Research Summary

PI on BBSRC grant The Immunological Toolbox (part of the Combating Viral Diseases of Livestock Initiative) 2004-2008. Specialist area Equine Immunology. Part of consortium (pigs, cattle, sheep,… read more

Selected Publications

Current Research

PI on BBSRC grant The Immunological Toolbox (part of the Combating Viral Diseases of Livestock Initiative) 2004-2008. Specialist area Equine Immunology. Part of consortium (pigs, cattle, sheep, chickens, horses) linked with BBSRC Institutes of Animal Health and Moredun Research Institute (SEERAD)

Coordinator of EU FP7 Grant: Novel technologies for Surveillance of Emerging and Re-emerging Infections of Wildlife (Acronym = WildTech). Total budget €8.1M, total requested from EU €5.9M, total award to University of Nottingham €1.4M. Co-applicants from Nottingham are Paul Barrow, Lisa Yon, Richard Lea (SVMS) and Susie Boardman (EMZS, Twycross Zoo, Clinical Associate of the School). There are 13 international partners mainly in EU and one in Canada. Start date for the project is July 2009, ends Dec 2013.

Past Research

Any area of veterinary immunology, in particular respiratory diseases, vaccinology and canine atopic dermatitis.

School of Veterinary Medicine and Science

University of Nottingham
Sutton Bonington Campus
Leicestershire, LE12 5RD

telephone: +44 (0)115 951 6116
fax: +44 (0)115 951 6415
email: veterinary-enquiries@nottingham.ac.uk