Janet Daly

Contact

• workSutton Bonington Campus
  Sutton Bonington
  Leicestershire
  LE12 5RD
  UK
• work0115 951 6475
• janet.daly@nottingham.ac.uk

Biography

Janet Daly obtained a BSc (Hons) in Animal Physiology and Nutrition from the University of Leeds. She then worked as a laboratory technician at the Animal Health Trust for a year before beginning part-time study towards a PhD on equine influenza. After gaining her PhD in 1995, she moved into the human influenza field, first at the National Institute of Biological Standards and Control, then at Glaxo Wellcome (now Glaxo Smithkline). She returned to the Animal Health Trust in 2001 where she built up the influenza group over the next 5 years. Although she then moved to the University of Liverpool to study immunopathology of Japanese encephalitis virus, she maintained her involvement in equine virology. After a brief spell as a medical writer, she joined the School of Veterinary Medicine and Science in 2009.

Expertise Summary

• Epidemiology and evolution of viruses
• Development and testing of viral vaccines, antivirals and diagnostics
• Science communication

Teaching Summary

Undergraduate teaching (BVM BVS)

Module convener Personal and Professional Skills Years 1 and 2

• Academic integrity and plagiarism
• Immunological assays
• Equine respiratory physiology
• Scientific writing
• Haemostatic disorders
• Information technology
• Animal Handling (small mammal and equine)

Additional

• Numeracy
• NUVACS (communication skills) facilitator
• Postgraduate training (EndNote)

Research Summary

My main research interests are in emerging and re-emerging zoonotic RNA viruses, particularly influenza A viruses and the flaviviruses Japanese encephalitis and West Nile.

I am fascinated with the complex interactions between viruses and their host and how studying these can lead to better understanding of determinants of viral pathogenicity and the host response to vaccination. I also have an interest in factors influencing interspecies transmission and the use of mathematical models to further understanding of disease transmission.

More recently, I have been involved in studies of the recently emerged Schmallenberg virus.

I also get involved in a wider range of research areas through undergraduate research projects and am a member of the Education Research Group (see Teaching and Learning).

See the Animal Infection and Immunity research theme web page for more information on virus research within SVMS.

Recent Publications

• MURCIA PR, BAILLIE GJ, STACK JC, JERVIS C, ELTON D, MUMFORD JA, DALY J, KELLAM P, GRENFELL BT, HOLMES EC and WOOD JLN, 2013. Evolution of equine influenza virus in vaccinated horses. Journal of virology. (In Press.)
• CARNEY J, DALY JM, NISALAK A and SOLOMON T, 2012. Recombination And Positive Selection Identified In Complete Genome Sequences Of Japanese Encephalitis Virus. Archives Of Virology. 157(1), 75-83
• DALY JM, 2012. Neuraminidase Inhibitors For Treatment Of Equine Influenza - When All Else Fails? Veterinary Journal (London, England : 1997). (In Press.)
• SIMON SCOTT, ELEONORA MOLESTI, NIGEL TEMPERTON, EVA BÖTTCHER-FRIEBERTSHÄUSER and JANET DALY, 2012. The use of equine influenza pseudotypes for serological screening J Mol Genet Med. 6, (In Press.)

• View all publications

Science Communication

• I am a strong supporter of communicating science to the public. This has led me to be involved in various outreach activities such as May Fest, the University of Nottingham's Open Day, and Science Week open days as well as visits by school groups.
• I have also contributed to 'Microshorts' in the Society for General Microbiology's magazine 'Microbiology Today' and the SGM Blog.
• In addition, I have contributed to non-specialist books: Pferdeinfluenza: Virologie, Epidemiologie, Klinik, Therapie und Prophylaxe and The Chicken

Undergraduate research projects

• An investigation into the prevalence of house dust mites in the equine environment (2010)
• An investigation into the occurrence of Staphylococcus on the hair of ferrets without dermatological disease (2010)
• Mosquitoes as vectors of disease within the British Isles with particular reference to the Flaviviruses: molecular methods for their surveillance (2010)
• The development of PCR primers for the identification of British mosquito species (2011)
• The impact of increased exercise and dietary supplementation on weight loss in the obese equine (2011)
• Characterization of a model of canine atopic dermatitis in terms of changes to skin barrier function (2011)
• Characterization of the cutaneous microbiological populations in a model of canine atopic dermatitis (2011)
• Survey for potential Schmallenberg virus vectors (2012)
• Influence of obesity on immune responses of equids to influenza vaccination (2012)
• Is colonization with methicillin-resistant Staphylococcus an occupational risk for veterinary students and clinicians? (2012)
• Factors in transmission of equine influenza virus to dogs (2012)

• MURCIA PR, BAILLIE GJ, STACK JC, JERVIS C, ELTON D, MUMFORD JA, DALY J, KELLAM P, GRENFELL BT, HOLMES EC and WOOD JLN, 2013. Evolution of equine influenza virus in vaccinated horses. Journal of virology. (In Press.)
• CARNEY J, DALY JM, NISALAK A and SOLOMON T, 2012. Recombination And Positive Selection Identified In Complete Genome Sequences Of Japanese Encephalitis Virus. Archives Of Virology. 157(1), 75-83
• DALY JM, 2012. Neuraminidase Inhibitors For Treatment Of Equine Influenza - When All Else Fails? Veterinary Journal (London, England : 1997). (In Press.)
• SIMON SCOTT, ELEONORA MOLESTI, NIGEL TEMPERTON, EVA BÖTTCHER-FRIEBERTSHÄUSER and JANET DALY, 2012. The use of equine influenza pseudotypes for serological screening J Mol Genet Med. 6, (In Press.)
• DALY, JANET M, MACRAE, SHONA, NEWTON, J RICHARD, WATTRANG, EVA and ELTON, DEBRA M, 2011. Equine influenza: A review of an unpredictable virus. Veterinary journal. 89, 7-14
• LEWIS, N.S., DALY, J.M., RUSSELL, C.A., HORTON, D.L., SKEPNER, E., BRYANT, N.A., BURKE, D.F., RASH, A.S., WOOD, J.J.L.N., CHAMBERS, T.M., FOUCHIER, R.A.M., MUMFORD, J.A., ELTON, D.M. and SMITH, D.J., 2011. Antigenic and genetic evolution of equine influenza A(H3N8) virus from 1968-2007. Journal of Virology. 85(23), 12742-12749
• TARLINTON, R.E., TATE, H.F.J., MOHALLAL, E.M.E., DALY, J.M. and BEHNKE, J.M., 2011. Betaherpesvirus sequences in eastern spiny mice and Wagner's dipodils Journal of Wildlife Diseases. 47(4), 958-962
• BAGUELIN M, NEWTON JR, DEMIRIS N, DALY J, MUMFORD JA, WOOD, JL, 2010. Control of equine influenza: scenario testing using a realistic metapopulation model of spread. Journal Of The Royal Society Interface. 7, 67-79
• MURCIA, P.R., BAILLIE, G.J., DALY, J., ELTON, D., JERVIS, C., MUMFORD, J.A., NEWTON, R., PARRISH, C.R., HOELZER, K., DOUGAN, G., PARKHILL, J., LENNARD, N., ORMOND, D., MOULE, S. and WHITWHAM, A., 2010. Intra- and interhost evolutionary dynamics of equine influenza virus Journal of Virology. 84(14), 6943-6954
• SAENZ, R.A., QUINLIVAN, M., ELTON, D., MACRAE, S., BLUNDEN, A.S., MUMFORD, J.A., DALY, J.M., DIGARD, P., CULLINANE, A., GRENFELL, B.T., MCCAULEY, J.W., WOOD, J.L.N. and GOG, J.R., 2010. Dynamics of influenza virus infection and pathology Journal of Virology. 84(8), 3974-3983
• LEWTHWAITE, P, SHANKAR, MV, TIO, PH, DALY, J, LAST, A, RAVIKUMAR, R, DESAI, A, RAVI, V, CARDOSA, JM and SOLOMON, T, 2010. Evaluation Of Two Commercially Available Elisas For The Diagnosis Of Japanese Encephalitis Applied To Field Samples Tropical Medicine & International Health. 15(7), 811-818
• BARBIC L, MADIC J, TURK N, DALY J, 2009. Vaccine failure caused an outbreak of equine influenza in Croatia. Veterinary Microbiology. 133(1-2), 164-71
• BRYANT NA, RASH AS, RUSSELL CA, ROSS J, COOKE A, BOWMAN S, MACRAE S, LEWIS NS, PAILLOT R, ZANONI R, MEIER H, GRIFFITHS LA, DALY JM, TIWARI A, CHAMBERS TM, NEWTON JR, ELTON DM, 2009. Antigenic and genetic variations in European and North American equine influenza virus strains (H3N8) isolated from 2006 to 2007. Veterinary Microbiology. 138(1-2), 41-52
• DOU J, DALY J, YUAN Z, JING T, SOLOMON T, 2009. Bacterial cell surface display: a method for studying Japanese encephalitis virus pathogenicity. Japanese journal of infectious diseases. 62(5), 402-8
• PARK, A.W., DALY, J.M., LEWIS, N.S., SMITH, D.J., WOOD, J.L.N. and GRENFELL, B.T., 2009. Quantifying the impact of immune escape on transmission dynamics of influenza Science. 326(5953), 726-8
• PAILLOT R, GRIMMETT H, ELTON D, DALY JM, 2008. Protection, systemic IFNgamma, and antibody responses induced by an ISCOM-based vaccine against a recent equine influenza virus in its natural host. Veterinary research. 39(3), 21
• HOPKINS MJ, REDMOND C, SHAW JM, HART IJ, HART CA, SMYTH RL SEMPLE MG, 2008. Detection and characterisation of human metapneumovirus from children with acute respiratory symptoms in north-west England, UK. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 42(3), 273-9
• DALY JM, BLUNDEN AS, MACRAE S, MILLER J, BOWMAN SJ, KOLODZIEJEK J, NOWOTNY N, SMITH KC, 2008. Transmission of equine influenza virus to English foxhounds. Emerging infectious diseases. 14(3), 461-4
• PAILLOT R, KYDD JH, MACRAE S, MINKE JM, HANNANT D, DALY JM, 2007. New assays to measure equine influenza virus-specific Type 1 immunity in horses. Vaccine. 25(42), 7385-98
• PAILLOT R, DALY JM, LUCE R, MONTESSO F, DAVIS-POYNTER N, HANNANT D, KYDD JH, 2007. Frequency and phenotype of EHV-1 specific, IFN-gamma synthesising lymphocytes in ponies: the effects of age, pregnancy and infection. Developmental and Comparative Immunology. 31(2), 202-14
• DALY J, DAAS A, BEHR-GROSS M-E, 2007. Collaborative study for the establishment of a candidate equine influenza subtype 2 American-like strain A/EQ/South Africa/4/03 - horse antiserum biological reference preparation. Pharmeuropa bio / the Biological Standardisation Programme, EDQM. 2007(1), 7-14
• DALY J, 2007. Virologie. In: LANGE W, ed., Pferdeinfluenza Parey. 4-28
• DALY JM, SINDLE T, TEARLE J, BARQUERO N, NEWTON JR, CORNING S, 2007. Equine influenza vaccine containing older H3N8 strains offers protection against A/eq/South Africa/4/03 (H3N8) strain in a short-term vaccine efficacy study. Equine Veterinary Journal. 39(5), 446-50
• BARQUERO N, DALY JM, NEWTON JR, 2007. Risk factors for influenza infection in vaccinated racehorses: lessons from an outbreak in Newmarket, UK in 2003. Vaccine. 25(43), 7520-9
• ATASEVEN VS, DALY JM, 2007. Seroepidemiology of equine influenza virus in Turkey Turkish J Vet An Sci. 198-202
• DALY JM, NEWTON JT, SMITH KC, MUMFORD JA, 2006. Epidemiology of equine influenza Medicinske zanosti. 30, 87-94
• PAILLOT R, ELLIS SA, DALY JM, AUDONNET JC, MINKE JM, DAVIS-POYNTER N, HANNANT D, KYDD JH, 2006. Characterisation of CTL and IFN-gamma synthesis in ponies following vaccination with a NYVAC-based construct coding for EHV-1 immediate early gene, followed by challenge infection. Vaccine. 24(10), 1490-500
• PAILLOT R, HANNANT D, KYDD JH, DALY JM, 2006. Vaccination against equine influenza: quid novi? Vaccine. 24(19), 4047-61
• MCCABE VJ, SINDLE T, DALY JM, 2006. Evaluation of the Binax NOW Flu A test kit for the rapid detection of equine influenza virus. Veterinary Record. 158(5), 164-5
• DALY JM, WHITWELL KE, MILLER J, DOWD G, CARDWELL JM, SMITH KC, 2006. Investigation of equine influenza cases exhibiting neurological disease: coincidence or association? Journal of comparative pathology. 134(2-3), 231-5
• DALY JM, 2006. Equine influenza in dogs: too late to bolt the stable door? The Veterinary Journal. 171(1), 7-8
• PAILLOT R, KYDD JH, SINDLE T, HANNANT D, EDLUND TOULEMONDE C, AUDONNET JC, MINKE JM, DALY JM, 2006. Antibody and IFN-gamma responses induced by a recombinant canarypox vaccine and challenge infection with equine influenza virus. Veterinary Immunology and Immunopathology. 112(3-4), 225-33
• WOOD J, SMITH KC, DALY J, NEWTON JR, 2006. Viral infections of the equine respiratory tract. In: MCGORUM B, ROBINSON E, SCHUMACHER J, DIXON P, ed., Equine respiratory medicine and surgery Saunders, Elsevier.
• ZÜRCHER T, YATES PJ, DALY J, SAHASRABUDHE A, WALTERS M, DASH L, TISDALE M, MCKIMM-BRESCHKIN JL, 2006. Mutations conferring zanamivir resistance in human influenza virus N2 neuraminidases compromise virus fitness and are not stably maintained in vitro. Journal of Antimicrobial Chemotherapy. 58(4), 723-32
• BARBIC J, DALY JM, RUDAN N, KOVAC S, SAVIC V, CVETNIC S, MADIC J, 2006. An outbreak of equine influenza (H3N8) in Croatia in 2004 caused by South American lineage Medicinske znanosti. 30, 63-71
• NEWTON JR, DALY JM, SPENCER L, MUMFORD JA, 2006. Description of the outbreak of equine influenza (H3N8) in the United Kingdom in 2003, during which recently vaccinated horses in Newmarket developed respiratory disease. Veterinary Record. 158(6), 185-92
• CROUCH CF, DALY J, HENLEY W, HANNANT D, WILKINS J, FRANCIS MJ, 2005. The use of a systemic prime/mucosal boost strategy with an equine influenza ISCOM vaccine to induce protective immunity in horses. Veterinary Immunology and Immunopathology. 108(3-4), 345-55
• SMITH KC, DALY JM, BLUNDEN AS, LAURENCE CJ, 2005. Canine influenza virus. Veterinary Record. 157(19), 599
• EDLUND TOULEMONDE C, DALY J, SINDLE T, GUIGAL PM, AUDONNET JC, MINKE JM, 2005. Efficacy of a recombinant equine influenza vaccine against challenge with an American lineage H3N8 influenza virus responsible for the 2003 outbreak in the United Kingdom. Veterinary Record. 156(12), 367-71
• GRAVENSTEIN S, DRINKA P, OSTERWEIL D, SCHILLING M, KRAUSE P, ELLIOTT M, SHULT P, AMBROZAITIS A, KANDEL R, BINDER E, HAMMOND J, MCELHANEY J, FLACK, N, DALY J, KEENE O, 2005. Inhaled zanamivir versus rimantadine for the control of influenza in a highly vaccinated long-term care population. Journal of the American Medical Directors Association. 6(6), 359-66
• PAILLOT R, DALY JM, JUILLARD V, MINKE JM, HANNANT D, KYDD J H, 2005. Equine interferon gamma synthesis in lymphocytes after in vivo infection and in vitro stimulation with EHV-1. Vaccine. 23(36), 4541-51
• BORCHERS K, DALY J, STIENS G, KRELING K, KRELING I, LUDWIG, 2005. Characterisation of three equine influenza A H3N8 viruses from Germany (2000 and 2002): evidence for frozen evolution. Veterinary Microbiology. 107(1-2), 13-21
• DALY JM, YATES PJ, NEWTON J, PARK A, HENLEY W, WOOD JLN, DAVIS-POYNTER N, MUMFORD JA, 2004. Evidence supporting the inclusion of strains from each of the two co-circulating lineages of H3N8 equine influenza virus in vaccines. Vaccine. 22(29-30), 4101-9
• GRENFELL BT, PYBUS OG, GOG JR, WOOD JLN, DALY JM, MUMFORD JA, HOLMES EC, 2004. Unifying the epidemiological and evolutionary dynamics of pathogens. Science. 303(5656), 327-32
• PARK AW, WOOD JLN, DALY JM, NEWTON JR, GLASS K, HENLEY W, MUMFORD JA, GRENFELL BT, 2004. The effects of strain heterology on the epidemiology of equine influenza in a vaccinated population. Proceedings of the Royal Society B: Biological Sciences. 271(1548), 1547-55
• DALY JM, NEWTON JR, MUMFORD JA, 2004. Current perspectives on control of equine influenza. Veterinary research. 35(4), 411-23
• CROUCH CF, DALY J, HANNANT D, WILKINS J, FRANCIS MJ, 2004. Immune responses and protective efficacy in ponies immunised with an equine influenza ISCOM vaccine containing an 'American lineage' H3N8 virus. Vaccine. 23(3), 418-25
• MUMFORD J, CARDWELL J, DALY J, NEWTON R, 2003. Efforts to pre-empt an equine influenza epidemic. Veterinary Record. 152(13), 405-6
• DALY JM, YATES PJ, BROWSE G, SWANN Z, NEWTON JR, JESSETT D, DAVIS-POYNTER N, MUMFORD JA, 2003. Comparison of hamster and pony challenge models for evaluation of effect of antigenic drift on cross protection afforded by equine influenza vaccines. Equine Veterinary Journal. 35(5), 458-62
• MUMFORD JA, DALY JM, WADE J, ed., 2003. Proceedings of the 4th International Meeting of OIE and WHO Experts on Control of Equine Influenza: Surveillance and Vaccine Efficacy: The American Perspective, Miami, Florida Havemeyer Foundation Monograph Series 7. (In Press.)
• WOOD JL, NEWTON JR, DALY J, PARK AW, MUMFORD JA, 2003. It's all in the mix: infection transmission in populations Equine Veterinary Journal. 35, 526-8
• PARK AW, WOOD JLN, NEWTON JR, DALY J, MUMFORD JA, GRENFELL BT, 2003. Optimising vaccination strategies in equine influenza. Vaccine. 21(21-22), 2862-70
• VAN MAANEN C, VAN ESSEN GJ, MINKE J, DALY JM, YATES PJ, 2003. Diagnostic methods applied to analysis of an outbreak of equine influenza in a riding school in which vaccine failure occurred. Veterinary Microbiology. 93(4), 291-306
• DALY J, 2002. Vorbeugung der Pferdeinfluenza. In: LINDNER A, ed., Optimisierung des Impfmanagements gegen Atemwegserkrankungen beim Pferd Arbeitsgrupper Pferd. 41-51
• TISDALE M, DALY J, GOR D, 2001. Methods for determining resistance to neuraminidase inhibitors International Congress Series. 1219, 879-886
• DALY JM, MUMFORD JA, 2001. Influenza infections IVIS. Available at: <http://www.ivis.org.uk>
• JOHNSON PA, CONWAY MA, DALY J, NICOLSON C, ROBERTSON J, MILLS KH, 2000. Plasmid DNA encoding influenza virus haemagglutinin induces Th1 cells and protection against respiratory infection despite its limited ability to generate antibody responses. Journal of General Virology. 81(Pt 7), 1737-45
• WOOD JM, MAJOR D, DALY J, NEWMAN RW, DUNLEAVY U, NICOLSON C, ROBERTSON JS, SCHILD GC, LEE-LIN YN, 1999. Vaccines against H5N1 influenza. Vaccine. 18(7-8), 579-80
• DALY JM, WOOD JM, ROBERTSON JS, 1998. Co-circulation and divergence of human influenza viruses. In: NICHOLSON KG, WEBSTER RG, HAY AJ, ed., Textbook of Influenza Blackwell Science. 169-180
• DALY JM, LAI AC, BINNS MM, CHAMBERS TM, BARRANDEGUY M, MUMFORD JA, 1996. Antigenic and genetic evolution of equine H3N8 influenza A viruses. Journal of General Virology. 77 ( Pt 4), 661-71
• LAI AC, LIN YP, POWELL DG, SHORTRIDGE KF, WEBSTER RG, DALY J, CHAMBERS TM, 1994. Genetic and antigenic analysis of the influenza virus responsible for the 1992 Hong Kong equine influenza epizootic. Virology. 204(2), 673-9
• BINNS MM, DALY JM, CHIRNSIDE ED, MUMFORD JA, WOOD JM, RICHARDS CM, DANIELS RS, 1993. Genetic and antigenic analysis of an equine influenza H 3 isolate from the 1989 epidemic. Archives of virology. 130(1-2), 33-43