Katie Woad graduated from Manchester University in 1994 with a BSc in Biology (Hons) followed by an MSc in Reproductive Biology from Edinburgh University. She went on to do a PhD at the Roslin Institute where she investigated the role of the insulin-like growth factor system in the bovine corpus luteum; research which she developed in a subsequent postdoctoral position. Katie then moved to Auckland (New Zealand) where she studied the regulation of premature ovarian failure and breast cancer, before returning to the UK in 2008 to join the Division of Animal Sciences at the University of Nottingham to work on a project on ovarian angiogenesis. She was appointed as a lecturer in Reproductive Physiology at the School of Veterinary Medicine and Science in 2011.
Katie Woad is a Lecturer in Reproductive Physiology. She is involved in teaching aspects of Reproduction as part of the Introduction to Body Systems (Preliminary Year) and Veterinary Reproduction 1 modules. She facilitates sessions in Personal and Professional Skills 1. She is module convenor for Veterinary Urinary 1.
Understanding the fundamental events that regulate normal ovarian function is key to improving our management of ovarian dysfunction and infertility in women and livestock animals.
My recent research has investigated the factors which regulate the growth of blood vessels, or angiogenesis, in the bovine ovary. Reproductive tissues are amongst the few tissues of the body that undergo cycles of growth and development, accompanied by dramatic changes in the vascular system. We have developed a novel culture system which mimics ovarian angiogenesis and provides a unique opportunity to investigate its complex regulation.
Future studies will investigate the role of Forkhead transcription factors in regulating ovarian function. Forkhead box or FOX proteins are a family of transcription factors that regulate the expression of critical genes involved in developmental processes, the cell cycle and growth, proliferation and differentiation. Several members of the FOX family are thought to be important regulators of ovarian function, although remarkably little is known about their roles and mechanism of action. Future studies will investigate the roles that FOX factors may play in regulating follicular growth and atresia as well as luteal development and regression.
Much of my previous research has focused on the role of growth factors in regulating aspects of ovarian function. I have also been interested in finding and characterising genes and polymorphisms associated with premature ovarian failure (early menopause) in women. I have also previously established a tissue banking programme for the genetic analysis of breast cancer tissue.
ANITA MUTHUKARUPPAN, ANNETTE LASHAM, KATHRYN J WOAD, MICHAEL A BLACK, CHERIE BLENKIRON, LANCE D MILLER, GAVIN HARRIS, NICOLE MCCARTHY, MICHAEL P FINDLAY and ANDREW N SHELLING, 2017. Multimodal assessment of oestrogen receptor mRNA profiles to quantify oestrogen pathway activity in breast tumours Clinical Breast Cancer. 17(2), 139–153 KATHRYN J WOAD and ROBERT S ROBINSON, 2016. Luteal angiogenesis and its control Theriogenology. 86(1), 221-228 PRENDERGAST D, WOAD KJ, CHAMLEY LW, HOLLAND OJ and SHELLING AN, 2014. SPACA3 gene variants in a New Zealand cohort of infertile and fertile couples. Human Fertility. 17(2), 106-13
LAIRD, M., WOAD, K.J., HUNTER, M.G., MANN, G.E. and ROBINSON, R.S., 2013. Fibroblast growth factor 2 induces the precocious development of endothelial cell networks in bovine luteinising follicular cells Reproduction, Fertility, and Development. 25(2), 372-386