School of Veterinary Medicine and Science
   
   
  
 

Image of Kin-Chow Chang

Kin-Chow Chang

Professor of Veterinary Molecular Medicine, Faculty of Medicine & Health Sciences

Contact

  • workRoom A14a Veterinary Academic Building
    Sutton Bonington Campus
    Sutton Bonington
    Leicestershire
    LE12 5RD
    UK
  • work0115 951 6491

Biography

Kin-Chow Chang qualified as a veterinary surgeon from the University of Bristol. He carried out post-graduate research training at University College London (MSc with Distinction), and at the Royal Veterinary College (RVC), University of London (PhD). He remained at the RVC as a Wellcome Trust Postdoctoral Fellow until 1995 when he joined the Roslin Institute as a Principal Investigator working on the molecular biology and genetics of skeletal muscle. He subsequently took up a senior lectureship at the University of Glasgow veterinary school becoming a Reader in 2006. He joined Nottingham in 2008 as Professor of Veterinary Molecular Medicine with active research programmes on host innate resistance to influenza A viruses and skeletal muscle biology.

Expertise Summary

Prof. Chang is a Fellow of the Royal College of Veterinary Surgeons, and a Visiting Professor of Liaoning Medical University, China. He has been a member of the Portuguese Animal and Veterinary Sciences Research Committee, Foundation for Science and Technology (FCT) and a member of the scientific committee of the Petplan Charitable Trust. He was a member of the BBSRC Agri-Food Research Committee and convenor of the fourth year undergraduate module of Veterinary Public Health. He is external examiner of the second year BVetMed degree at the Royal Veterinary College. He is in the editorial board of Scientific Reports.

Research Summary

Mammalian host innate resistance to pathogenic influenza virus infection

Influenza A virus infection is a major veterinary disease that affects a wide range of mammalian and avian species, and is a serious zoonotic threat to human public health. We have a major research programme on understanding the mechanisms of host innate disease resistance to influenza infections. One of our strategic approaches is to compare host response to virulent influenza virus infection (such as avian H5N1 virus) between resistant (e.g. pig, duck and bat) and susceptible (human and chicken) species to identify targets for the development of intervention therapy to reduce disease severity. Collaborators include colleagues from the Animal and Plant Health Agency, Weybridge (Prof. Ian Brown) and China Agricultural University (Prof. Jinhua Liu).

Molecular basis of phenotype determination in skeletal muscle of target and model animal species

We have a major research programme on understanding the basic and strategic biology of skeletal muscle development and growth in model and farm species. We conduct fundamental research of biomedical and agricultural importance in relation to muscle growth (hypertrophy and atrophy) and muscle as a major organ of host innate immunity. The aim is to identify host targets for intervention to improve the physical characteristics of muscle and its innate immunity during growth or at old age.

Recent Publications

School of Veterinary Medicine and Science

University of Nottingham
Sutton Bonington Campus
Leicestershire, LE12 5RD

telephone: +44 (0)115 951 6116
fax: +44 (0)115 951 6415
email: veterinary-enquiries@nottingham.ac.uk