School of Veterinary Medicine and Science
   
   
  
 

Image of Sharon Egan

Sharon Egan

Lecturer in Molecular Microbiology, Faculty of Medicine & Health Sciences

Contact

  • workRoom C21 School of Veterinary Medicine and Science, Main building
    Sutton Bonington Campus
    Sutton Bonington
    Leicestershire
    LE12 5RD
    UK
  • work0115 951 6659

Biography

Dr Egan studied at the University of Melbourne where she received a BSc(hons) in Microbiology and Immunology in 2002 followed by a PhD in conjunction with the CSIRO/Australian Animal Health Laboratories. Dr Egan's first Post-Doctoral appointment was with Streptococcal Research Group with Professor James Leigh at the University of Oxford. This was followed by a Post-doctoral Research Fellow position through the School of Veterinary Medicine and Sciences, whilst based at the Institute for Animal Health. In 2011, Dr Egan re-located to SVMS and was appointed a Lecturer in Molecular Microbiology in 2014.

Teaching Summary

Dr Egan is the module convener for Principles of Animal Health and Disease 2 and Co-Convener for Principles of Animal Health and Disease 1 (School of Biosciences). She also teaches exotics animal… read more

Research Summary

My research interests mainly includes investigating host/pathogen dynamics in bacterial infections and the identification of virulence determinants for vaccine/diagnostic test development. Recent… read more

Recent Publications

Dr Egan is the module convener for Principles of Animal Health and Disease 2 and Co-Convener for Principles of Animal Health and Disease 1 (School of Biosciences). She also teaches exotics animal handling (reptiles) and molecular and microbiology techniques in CRS, LCB and PVS as well as PPS2.

Current Research

My research interests mainly includes investigating host/pathogen dynamics in bacterial infections and the identification of virulence determinants for vaccine/diagnostic test development. Recent work has focused on mastitis in dairy cattle caused by Streptococcus uberis, and bacterial diseases of fish, focusing on streptococcal and lactococcal infections. This work has included the evaluation of the role of sortase anchored proteins in the virulence of S. uberis. and the comparison of virulent and avirulent strains of S. uberis to detect pathogen & host factors critical to the pathogenesis of bovine mastitis.

Current work includes the functional annotation of Streptococcal genomes by analysing the effect of gene disruption using high density DNA sequencing and identifying specific genes and proteins essential for virulence. I am also interested in the dynamics of the host bacterial microbiome in disease prevention, opportunistic infection and immune tolerance, particularly in the gastrointestinal and skin epthelium of fish. It also includes an ecology-based study of Streptococcus uberis carriage and a potential infection route for mastitis. A further two studies investigate differences between the host microbiome balance in trout and the impact that changes in gene expression have on overall gastrointestinal health as well as the effect of change in environment the microbiome and ectoparasite infection of stickleback fish.

A new area of research we are currently working on involves the effect of pollution from antibiotic, bacterial and heavy metal contamination on food security and addresses factors in pig, cattle and fish related health in terms of production and the health and welfare of these animals.

Another aspect of my work involves the analysis of the microenvironment of tumors and identification of factors for immune-mediated tumor control, particularly investigating neuroblastoma and acute myeloid leukemia.

Previously I worked on Johne's disease and its causative agent Mycobacterium paratuberculosis in cattle, sheep and goats. Aspects of this work included isolation and characterisation of in vivo strains of M. paratuberculosis by using proteomics based methods including 2DE gel separation and mass spectrometry.

School of Veterinary Medicine and Science

University of Nottingham
Sutton Bonington Campus
Leicestershire, LE12 5RD

telephone: +44 (0)115 951 6116
fax: +44 (0)115 951 6415
email: veterinary-enquiries@nottingham.ac.uk