Simone de Brot is originally from Switzerland. Before starting her studies, she spent two years overseas in Australia working on a horse stud farm with Standardbred harness racing horses (www.peppertreefarm.org). Back home in Switzerland, she obtained a Degree in Veterinary Medicine (DVM) from the University of Zurich in 2010 (www.vet.uzh.ch).
She performed her doctoral thesis (Dr. med.vet.) at the Institute of Veterinary Pathology at the University of Zurich (www.vetpathology.uzh.ch). Her thesis involved functional studies of human and canine Bcl-2 family proteins in yeast (Saccharomyces cerevisiae).
From 2011 to 2014, she completed a residency program in veterinary pathology at the University of Zurich and successfully passed the board exam for the European College of Veterinary Pathologists (ECVP) in 2014.
Simone joined the Nottingham School of Veterinary Medicine and Science (SVMS) in March 2014 as a Clinical Lecturer in Veterinary Pathology (now Assistant Professor in Veterinary Pathology). In June 2015, she has started a part-time PhD that involves the study of human and canine cancer (bladder, prostate, bone, kidney) and acute kidney injury (main supervision by Dr Nigel Mongan). In September 2015, Simone has set up dog agility training at the SVMS where she gives classes every Wednesday evening for SVMS and Bioscience School staff and students.
During her doctoral thesis and residency in veterinary pathology, Simone worked in the pathology service of the Institute of Veterinary Pathology, University of Zurich. The duties included a large daily caseload of necropsies, biopsies and cytologies of domestic and farm as well as exotic and wild animals.
Since her arrival at the SVMS in March 2014, she works in the SVMS pathology service and teaches undergraduate students in histology and pathology, together with Llorenç Grau Roma and Kerstin Baiker. In March 2015, the pathology team has started a pathology (ECVP) residency programme with currently three residents who are being trained and supervised by all three pathologists.
Since 1994, Simone has been training dogs in agility and has competed ever since in the highest grades. In 2010 and 2011, she had the chance to compete at the FCI Agility World Championships where she won a silver medal for the Swiss Team in 2011.
Simone's main research interests involve:
- Human and canine cancer (bladder, prostate, bone, kidney)
- Pathology and genetics of canine diseases with breed predisposition
- Acute kidney injury
- Animal models for human disease (particularly dog and pig)
- Genomics and transcriptomics
- Dog behavior and performance
In June 2015, Simone has started a PhD that involves the study of human and canine cancer (bladder, prostate, bone, kidney) and acute kidney injury (main supervision Dr Nigel Mongan). Her main methods include epidemiology, histology, immunohistochemistry and next generation sequencing (RNA-seq).
In general, Simone is interested in pathologic and genetic studies of different infectious and non-infectious diseases of domestic, farm, exotic and wildlife animal species with an open mind for collaborative research.
METZLER VM, DE BROT S, ROBINSON RS, JEYAPALAN JN, RAKHA E, WALTON T, GARDNER DS, LUND EF, WHITCHURCH J, HAIGH D, LOCHRAY JM, ROBINSON BD, ALLEGRUCCI C, FRAY RG, PERSSON JL, ØDUM N, MIFTAKHOVA RR, RIZVANOV AA, HUGHES IA, TADOKORO-CUCCARO R, HEERY DM, RUTLAND CS and MONGAN NP, 2017. Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development. Placenta. S0143-4004(17), 30164-9 KAULFERS C, DE BROT S, HOWARD J and WERNICK MB, 2017. Pathology in Practice. Journal of the American Veterinary Medical Association. 250(7), 759-761 DE BROT S, ADAMANY J, BAIKER K, DHUMEAUX M, ALLEGRUCCI C, POLLEDO L and GRAU-ROMA L, 2017. Hereditary nephropathy in an English Cocker Spaniel. Pathology in Practice. Journal of the American Veterinary Medical Association. 251(6), 661-664
SIMPSON S, DUNNING MD, DE BROT S, GRAU-ROMA L, MONGAN NP and RUTLAND CS, 2017. Comparative review of human and canine Osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics Acta Veterinaria Scandinavica. (In Press.)