I received my BSc in Biology from the University of Bristol, my practical project being on trans-kingdom horizontal gene transfer and my literature project on bacterial symbionts in helminth parasites. I took a year out to apply for postgraduate positions and teach science at a London secondary school, which was a rewarding and stimulating experience. Part of the first cohort to enrol on the BBSRC Doctoral Training Partnership at Nottingham, I completed lab rotations in immunology, bacteriology and parasitology before starting work on my thesis.
School Research Theme:
Animal Infection and Immunity
Immunomodulatory properties of plant extracts from the Crops For The Future Research Centre
Summary of Research:
Plants all over the world have been a source of medicines for much of human history. My project involves searching for plant-derived compounds which either up- or down-regulate the mammalian immune system, with the intention of identifying the molecules in question, elucidating their mechanisms of action and starting in vivo work to establish their viability for use as novel vaccine adjuvants, anti-inflammatories or pharmaceuticals for treatment of autoimmune and immunodeficiency diseases. After screening the crude plant extracts against TLR-transfected HEK cells, any immunologically active extracts will be fractionated and the active TLR ligand identified, using knockout lines to determine the action and effect of each one in vitro and in vivo.
Prof David Haig
Dr Robin Flynn
Primary Funding Source: