Drug Discovery: African Sleeping Sickness
Originally posted by SDSC on SDSC's CI Channel at: www.cichannel.org Rommie Amaro, Computational and Theoretical Biophysical Chemist, discusses how she uses the resources at SDSC to conduct her drug discovery research on African Sleeping Sickness
HIV/AIDS TRENDS; Attention to AIDS wanes, but illness is still rampant
Arkansas' leaders are mistaken if they think the epidemic of acquired immune-deficiency syndrome is under control, according to advocates for AIDS support groups.
They expressed concern in an appearance before a legislative committee that authorities have become apathetic about the illness again.
The Arkansas AIDS Drug Assistance Program and Jefferson Comprehensive Care Inc. appealed to the joint legislative Minority Health Subcommittee for increased funding and new laws.
Healthy People 2010 disease prevalence in the Marshfield Clinic Personalized Medicine Research Proje
Objectives: The purpose of this study was to estimate the prevalence of Healthy People 2010 disease conditions in a large population-based cohort in central Wisconsin (WI, USA) and to consider how these conditions can be prioritized for research based on the use of healthcare services, the prevalence of various disease states and the resulting study power.
Methods: Healthy People 2010 diagnoses were estimated for participants in
the Personalized Medicine Research Project (PMRP), a large popula
Statistical analysis of the National Institutes of Health peer review system
A statistical model is proposed for the analysis of peer-review ratings of R01 grant applications submitted to the National Institutes of Health. Innovations of this model include parameters that reflect differences in reviewer scoring patterns, a mechanism to account for the transfer of information from an application's preliminary ratings and group discussion to final ratings provided by all panel members and posterior estimates of the uncertaninty associated with proposal ratings. Application
Guidelines for Teaching Middle and High School Students to Read and Write Well
Most classroom teachers work hard planning lessons, choosing materials, teaching classes, working with individual students, and assessing student progress. Yet some schools and teachers seem to be more successful than others. What makes the difference? This booklet is designed for middle and high school teachers and administrators who wish to improve their English programs. Guidelines for Teaching Middle and High School Students to Read and Write Well draw upon a series of research reports and c
A First Course in Complex Analysis
These are the lecture notes of a one-semester undergraduate course which we taught at SUNY Binghamton. For many of our students, Complex Analysis is their first rigorous analysis (if not mathematics) class they take, and these notes reflect this very much. We tried to rely on as few concepts from real analysis as possible. In particular, series and sequences are treated "from scratch." This also has the (maybe disadvantageous) consequence that power series are introduced very late in the course.
Accelerating Biology with Bioinformatics: Collaborations with Lab Scientists
Projects to facilitate collaboration between biologists and computer scientists. Lecture from the Women in Bioinformatics series. Fran Lewitter, Ph.D. Director of the Bioinformatics and Research Computing Department, Whitehead Institute, MIT
A New Tool for Epidemiology: The Usefulness of Dynamic Agent Models in Understanding Place Effects o
A major focus of recent work on the spatial patterning of health has been the study of how features of residential environments or neighborhoods may affect health. Place effects on health emerge from complex interdependent processes in which individuals interact with each other and their environment and in which both individuals and environments adapt and change over time. Traditional epidemiologic study designs and statistical regression approaches are unable to examine these dynamic processes.
Barbershops become urban community health centers
African-American communities in the shadows of the University of Pittsburgh's buildings are getting sick and dying sooner than their white counterparts, of preventable diseases -- and Dr. Stephen Thomas wants to change it.
An outreach initiative involving local barbershops and beauty salons is a step in that direction.
Compendium of HIV Prevention Interventions with Evidence of Effectiveness
The Centers for Disease Control and Prevention (CDC) developed this Compendium of HIV Prevention Interventions with Evidence of Effectiveness to respond to prevention service providers, planners, and others who request science-based interventions that work to prevent HIV transmission. All interventions selected for this Compendium came from behavioral or social studies that had both intervention and control/comparison groups and positive results for behavioral or health outcomes. We required des
PharmGenEdâ„¢ Asthma
This webinar was presented on Tuesday, November 2, 2010 by Dr. Alice Gardner. Dr. Gardner discusses select pharmacogenomic effects in patients with asthma.
Evaluation of springback prediction capability using uniform pure bending
The aim of this study is to develop uniform pure bending as an objective test for determining the accuracy of springback prediction by employing different FEA techniques. A complete theoretical solution for the bending moment and change in sheet thickness is available only for uniform pure bending of perfectly plastic sheets. However, plastic hinging develops naturally in simulations of bending perfectly plastic sheets. We have developed a method to prevent plastic hinging and achieve uniform pu
Transverse impact characteristics of adhesively bonded composite single lap joint
Impact force and deformation behavior of adhesively bonded single lap composite joints for transverse impact are studied through a pilot project and validated using Finite Element Analysis (FEA). At present there is no standard which provides guidelines in testing adhesively bonded joints or structures at coupon level. An attempt is made here to formulate the testing procedure through an experiment. Adhesively bonded glass-epoxy lap joints are transversely impacted using three different hemisphe
Design and evaluation of composite car-front subframe rails in a sedan and its corresponding occupan
Today occupant safety is of a prime concern to every car manufacturer. New standards are being set for the safety of the occupant in different crash scenarios like frontal head on collision, angle impacts, side impacts, rear impacts and rollover. Among these standards, frontal impact is one of the fatal crash scenarios that lead to death of scores of people in the United States and across the globe. The automotive mid-rail is the main load carrying/energy-absorbing component in a event of fronta
Distant Suffering in the Media
Professor Lilie Chouliaraki will talk about suffering in the media, addressing the question of how far images and stories of suffering make a difference in our ways of engaging with distant sufferers.Lilie Chouliaraki is chair in media and communications at the Department of Media and Communications and research director of POLIS at LSE.
The Ideas that are Changing Politics
There has been an extraordinary surge in the study of behaviour from evolutionary biologists, neurologists and game theorists, but this has been largely divorced from the political debate. David Willetts will draw on the latest research from these disciplines to explain what Government can and cannot do to influence our behaviour. David Willetts is shadow secretary of state for innovation, universities and skills and has been the MP for Havant since 1992. He was shadow secretary of state for wor
Transverse impact characteristics of adhesively bonded composite single lap joint
Impact force and deformation behavior of adhesively bonded single lap composite joints for transverse impact are studied through a pilot project and validated using Finite Element Analysis (FEA). At present there is no standard which provides guidelines in testing adhesively bonded joints or structures at coupon level. An attempt is made here to formulate the testing procedure through an experiment. Adhesively bonded glass-epoxy lap joints are transversely impacted using three different hemisphe
The histories of each: a collection of short fiction
The used couch -- Indian graveyard -- Heart disease -- Tree house -- Cravings -- Henderson’s grocery.,Thesis (M.A.)--Wichita State University, Dept. of English.,"May 2006."
Novel inhibitors of human leukocyte proteinase 3
Chronic obstructive pulmonary disease (COPD) is a multifactorial disorder that is associated with an influx of macrophages, neutrophils and T-lymphocytes to the lungs and the extracellular release of several proteases, including serine (proteinase 3, elastase, cathepsin G), cysteine (cathepsin S) and metallo- (macrophage metalloelastase, MMP-12) proteases, leading to a protease/antiprotease imbalance. The pathogenesis of COPD arises from an imbalance between the levels of proteases and their end
Dynamic voice codec determination mechanism for VoIP
Emerging voice over IP networks dictate a need for efficient network resource management schemes to mitigate the best-effort nature of IP. Traditional quality of service and call admission control mechanisms provide network resource allocation to static voice flows with parameters fixed by a selected voice codec. Frequently, the available bandwidth is not efficiently utilized, which results in a lower-than-possible average voice quality and potential wastage of resources. In this thesis, the aut
