5.4 The medical chemistry strategy The strategy adopted was to start from first principles. Since prazosin is an alpha1 antagonist, it must compete with the agonist, noradrenaline, for the alpha1 receptor. So the Pfizer scientists decided to compare the structures of the two molecules and look for common structural features that might provide an insight into the way in which they bind to the receptor. One important observation was the fact that, at physiological pH, both compounds would be protonated, nor
The strategy adopted was to start from first principles. Since prazosin is an alpha1 antagonist, it must compete with the agonist, noradrenaline, for the alpha1 receptor. So the Pfizer scientists decided to compare the structures of the two molecules and look for common structural features that might provide an insight into the way in which they bind to the receptor. One important observation was the fact that, at physiological pH, both compounds would be protonated, nor
2.007 EV Special Section wirelessly controlled electric skates hella buttplants! from 2.00EV
hella buttplants! from 2.00EV
Article :: Creative Lighting Effects with Adobe Photoshop CS6
Lighting Effects has been around a long time, but the Lighting Effects filter in Photoshop CS6 is essentially a brand new feature in the sense that it has been completely remade. This article provides a general overview of the filter (including its new interface), and demonstrates how you can use Lighting Effects to dramatically impact the composition or look of your photographs.
Article :: Creating a Page Layout with Adobe Dreamweaver CS6
In this lesson from Adobe Dreamweaver CS6 Classroom in a Book, you’ll learn the basics of webpage design, how to create design thumbnails and wireframes, insert and format new components into a predefined CSS layout, use Code Navigator to identify CSS formatting, and check for browser compatibility.
2012 Family Business of the Year: Warners' Stellian
2012 University of St. Thomas Opus College of Business Family Business of the Year Warners' Stellian Presented May 2, 2012
Lincon's Letter to His Son's Teacher
This selection features a slide show set to music. The slide show shows the words of the inspirational lettwe Abraham Lincoln wrote to his son's teacher. These words of wisdom could serve as motivation for both teachers and older srtudents. ( 3:19)
Closed-Loop Manufacturing System (Interactive)
In this interactive activity adapted from the Wisconsin Online Resource Center, learn about the elements of a closed-loop system. An animation illustrates typical components (such as an error detector, a controller, an actuator, and a measurement device), as well as the input and output signals for each component. The activity also allows you to compare the animation to a standard block diagram to see how the various elements in a closed-loop system can be represented in a simplified form.
Ping 140: Hyper-V on Technet, Wordament, Nook, Windows Phone Marketplace Laura was out this week but Paul didn't skip a beat and he was joined by our Hyper -V expert himself, Eric Bahna. Here's what went down:
Laura was out this week but Paul didn't skip a beat and he was joined by our Hyper -V expert himself, Eric Bahna. Here's what went down:
Vectors and Scalars
An introduction to scalars and vectors. This video teaches how to add and subtract vectors, as well as find the magnitude of a vector in a triangle, as long as you have the magnitude of one of the vectors and the measure of the angle.
A massive coal fire has been burning in Centralia, Pennsylvania since the early 1960s. In the 1980s, the town was abandoned for safety reasons. In this video clip, see what happens to a town after 25 years. (2:20)
7.8 Example 2 and questions Example 2 Show that the synchrotron spectrum produced by a power-law distribution of electron energies N(E) dE = N0E−s dE, is described by You may use the approximation that all the po
Show that the synchrotron spectrum produced by a power-law distribution of electron energies N(E) dE = N0E−s dE, is described by
You may use the approximation that all the po
Evolution Through Time
The fossil record reveals much about the diversity and development of species. This program examines the traces left by early plants, animals, and single-celled organisms and follows the progression of life forms over time. Connections are drawn between atmospheric gases, climate change, rock formation, biological functions, and mass extinctions.
Duke Chapel Live - 6/10/2012
A service of worship in Duke University Chapel. The Reverend Dr David Stubbs delivers a sermon entitled "Rescue and Release." Bulletin: http://bit.ly/KLOhk7 Opening Excerpt from the Sermon: (31:58) "When it comes to combating the forces of evil, there is no one quite like John Paul Letterock. Now, he may not be the new Sherlock Holmes or one of the Avengers, but still he is a bit of a hero to me. John Paul Letterock is a peace builder. For the past 25 years he has willingly walked into situat
Gerald Ford on Resignation of South Vietnam's President
In April 1975, when North Vietnamese forces reached Xuan Loc, Saigon's last line of defense, President Nguyen Van Thieu announced his resignation. In an interview, President Gerald Ford denies that the U.S. government influenced Thieu's decision to resign. (0:36)
Energy resources: Solar energy
Energy from sources other than fossil and nuclear fuels is to a large extent free of the concerns about environmental effects and renewability that characterize those two sources. Each alternative source supplies energy continuall, whether or not we use it, and most have their origins in energy generated outside the Earth, yet the potential of each is limited by its total supply set against its rate of use. The Sun will radiate energy until it ceases thermonuclear fusion, in around 5 billion yea
Drug destroys human cancer stem cells but not healthy ones
A team of scientists at McMaster University has discovered that the drug thioridazine successfully kills cancer stem cells in humans while avoiding the toxic side-effects of conventional cancer treatments.