5.4 The medical chemistry strategy

The strategy adopted was to start from first principles. Since prazosin is an alpha1 antagonist, it must compete with the agonist, noradrenaline, for the alpha1 receptor. So the Pfizer scientists decided to compare the structures of the two molecules and look for common structural features that might provide an insight into the way in which they bind to the receptor. One important observation was the fact that, at physiological pH, both compounds would be protonated, nor
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2.007 EV Special Section wirelessly controlled electric skates

hella buttplants! from 2.00EV


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7.8 Example 2 and questions

Example 2

Show that the synchrotron spectrum produced by a power-law distribution of electron energies N(E) dE = N0E−s dE, is described by

You may use the approximation that all the po
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