U.S. Morning Call: It's now or never for Obama & Romney
Nov 6 - U.S. stock futures pointing to a slightly higher open as U.S. voters head to the polls.
Author(s): No creator set

License information
Related content

Publish Your Book (or How to Meet the Challenges of the New Publishing Environment)
Office of Faculty Development & Diversity This panel on book publishing engaged faculty members from across the University in a discussion with publishing executives. It addressed some of the common questions scholars have about contracts, literary agents, and the promotional process for scholarly books. It also touched on how the environment for book publishing has changed in recent years as a result of new technologies and market forces. April 14, 2012
Author(s): No creator set

License information
Related content

Vincent van Gogh: Ear Offering
Work and solitude took its toll on van Gogh, and he started to act strangely from paint and turpentine fumes. Vincent van Gogh cut off his ear and delivered it to a prostitute. In this video clip, learn more about the life of van Gogh. (2:03)
Author(s): No creator set

License information
Related content

Pereira- Why Science- Entomology

Pereira- Why Science- Entomology
Explore Research at the University of Florida: Roberto Pereira, a UF research associate scientist, explains
Author(s): No creator set

License information
Related content

SP.722J D-Lab II: Design (MIT)
D-Lab: Design addresses problems faced by undeserved communities with a focus on design, experimentation, and prototyping processes. Particular attention is placed on constraints faced when designing for developing countries. Multidisciplinary teams work on semester-long projects in collaboration with community partners, field practitioners, and experts in relevant fields. Topics covered include design for affordability, design for manufacture, sustainability, and strategies for working effectiv
Author(s): Smith, Amy J.,Serrat, Victor Grau

License information
Related content

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative C

Map of Clinton County
[68] p. : maps. ; 26 x 37 cm.,Originally part of Clinton County, Honey Creek Township, in the far North East corner, including Russiaville, was partitioned to Howard County in 1859, at the request of residents. It was years afterward before some Indiana maps began showing the change.,Clinton County Journey
Author(s): Irick, Simon Henry, 1885-1969

License information
Related content

Digital Image © 2009 Indiana Historical Society. All Rights Reserved.

ABC 123 Energizing Brain Break
In this video, high school students help demonstrate a brain break by saying their numbers out loud while spelling their letters in the air, all at the same time!  (01:29)
Author(s): No creator set

License information
Related content

Peabody Interlude - Coventry Carol performed by Jeffrey Sharkey
There's a reason why Christmas carols start filling the air before we have polished off the last pieces of our Halloween candy. Craving a sense of community and drawn to ritual, we welcome the return of seasonal music, even if the calendar says we have several weeks to go before Dec. 25, according to Jeffrey Sharkey, director of the Peabody Institute at The Johns Hopkins University. In this video, Sharkey shares his personal history with the Coventry Carol, and explains why he is drawn in by th
Author(s): No creator set

License information
Related content

NASA | DNA Building Blocks Can Be Made in Space
NASA-funded researchers have evidence that some building blocks of DNA, the molecule that carries the genetic instructions for life, found in meteorites were likely created in space. The research gives support to the theory that a "kit" of ready-made parts created in space and delivered to Earth by meteorite and comet impacts assisted the origin of life. (02:50)

Author(s): No creator set

License information
Related content

The Secret of the Machines by Rudyard Kipling (poetry reading)
We were taken from the ore-bed and the mine, We were melted in the furnace and the pit— We were cast and wrought and hammered to design, We were cut and filed and tooled and gauged to fit. Some water, coal, and oil is all we ask, And a thousandth of an inch to give us play: And now, if you will set us to our task, We will serve you four and twenty hours a day! We can pull and haul and push and lift and drive, We can print and plough and weave and heat and light, We can run a
Author(s): No creator set

License information
Related content

Defrag Tools: #17 - WinDbg - Driver Verifier - Part 2 | Defrag Tools

In this episode of Defrag Tools, Michael Fourre, senior test engineer from the Driver Verifier team, pays a visit to Larry Larsen and Chad Beeder in the Channel 9 studios to give us some deeper insight into this valuable tool for catching device driver bugs!

Resources:

Debugging Tools for Windows

Author(s): Larry Larsen, Andrew Richards, Chad Beeder

Newegg TV: How To Build a Computer - Part 1 - Choosing Your Components
How to build a PC from the ground up first by showing how to choose the parts. (24:33)
Author(s): No creator set

License information
Related content

Acknowledgements

The content acknowledged below is Proprietary (see terms and conditions). This content is made available under a Creative Commons Attribution-NonCommercial-ShareAlike 2.0 Licence

Grateful acknowledgement is made to the following sources for permission to reproduce material in this unit:

The content acknowledged
Author(s): The Open University

License information
Related content

Except for third party materials and/or otherwise stated (see terms and conditions) the content in OpenLearn is released for use under the terms of the Creative Commons Attribution-NonCommercial-Share

5.4 The medical chemistry strategy

The strategy adopted was to start from first principles. Since prazosin is an alpha1 antagonist, it must compete with the agonist, noradrenaline, for the alpha1 receptor. So the Pfizer scientists decided to compare the structures of the two molecules and look for common structural features that might provide an insight into the way in which they bind to the receptor. One important observation was the fact that, at physiological pH, both compounds would be protonated, nor
Author(s): The Open University

License information
Related content

Except for third party materials and/or otherwise stated (see terms and conditions) the content in OpenLearn is released for use under the terms of the Creative Commons Attribution-NonCommercial-Share

5.3 Project initiation

In the early 1970s a discovery was made independently by two different researchers, Klaus Starke in Germany and Salomon Langer in Argentina. Their results showed that there were two types of alpha receptor. The first type, which they called alpha1 is the one already described that is found on the blood vessel wall. The second type, which they called alpha2, is located on the nerve-ending itself. Noradrenaline binds to the alpha2 receptors when the alpha
Author(s): The Open University

License information
Related content

Except for third party materials and/or otherwise stated (see terms and conditions) the content in OpenLearn is released for use under the terms of the Creative Commons Attribution-NonCommercial-Share

4 Summary of video

At the beginning of the video clip, Dr Simon Campbell pointed out that, in the development of any drug, there are a number of criteria that must be satisfied. There must be a clinical need – a medical condition or disease that requires effective treatment. Secondly, there has to be a commercial opportunity; because drug development is so expensive, pharmaceutical companies are less likely to invest resources in developing new therapeutic agents where there is already an adequate range of su
Author(s): The Open University

License information
Related content

Except for third party materials and/or otherwise stated (see terms and conditions) the content in OpenLearn is released for use under the terms of the Creative Commons Attribution-NonCommercial-Share

3 Reading activity

You will shortly be asked to read through a research paper published in the Journal of Medicinal Chemistry, in which the synthesis and structure–activity relationships of doxazosin and related compounds are described. It has been provided:
Author(s): The Open University

License information
Related content

Except for third party materials and/or otherwise stated (see terms and conditions) the content in OpenLearn is released for use under the terms of the Creative Commons Attribution-NonCommercial-Share

2 Video activity

The video clip included in this section looks at the development of one particular drug. It examines the complex multidisciplinary process that was involved in its discovery. Before you watch the video, read through the Pre-viewing notes.


Author(s): The Open University

License information
Related content

Except for third party materials and/or otherwise stated (see terms and conditions) the content in OpenLearn is released for use under the terms of the Creative Commons Attribution-NonCommercial-Share

1 The chemical industry

The chemical industry is one of the major contributors to the economies of advanced industrial nations.

The importance of organic chemistry in the pharmaceutical industry becomes apparent in the light of the fact that in the UK alone some £2.2b was spent in 1997 on research and development. Literally thousands of different compounds have to be synthesised and tested in the search for the one that will prove to be a successful and valuable therapeutic agent. As a result, the average cos
Author(s): The Open University

License information
Related content

Except for third party materials and/or otherwise stated (see terms and conditions) the content in OpenLearn is released for use under the terms of the Creative Commons Attribution-NonCommercial-Share

Introduction

This unit examines how organic chemistry is used within the pharmaceutical industry to develop new drugs. You will investigate the process of drug development by following one new product through the intial process and research programme.

This unit is from our archive and it is an adapted extract from Organic chemistry: A synthesis approach (S344) which is no longer in presentation. If you wish to study formally at The Open University, you may wish to explore the courses we offer
Author(s): The Open University

License information
Related content

Except for third party materials and/or otherwise stated (see terms and conditions) the content in OpenLearn is released for use under the terms of the Creative Commons Attribution-NonCommercial-Share