Welcome to Computing1 MOOC - Richard Buckland UNSW
Join the course at http://www.openlearning.com/courses/unsw/computing1
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Build 2012 Hackathon Kickoff

The Build hackathon is underway and loads of developers are hard at work creating apps for Windows 8, Windows Azure and Windows Phone 8. I stopped by just as they kicked off and caught some of the pre-event excitement. Take a look!


Author(s): Clint Rutkas, Laura Foy

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President of UCLU American Society on 2012 US Election
Beatrice Kelly, a second-year History of Art student and President of UCLU American Society, gives her reaction to Barack Obama's historic re-election and describes her hopes for America.
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5.33 Advanced Chemical Experimentation and Instrumentation (MIT)
5.33 focuses on advanced experimentation, with particular emphasis on chemical synthesis and the fundamentals of quantum chemistry, illustrated through molecular spectroscopy. The written and oral presentation of experimental results is also emphasized in the course. Acknowledgements The materials for 5.33 reflect the work of many faculty members associated with this course over the years. WARNING NOTICE The experiments described in these materials are potentially hazardous and require a high
Author(s): Gheorghiu, Mircea,Tokmakoff, Andrei

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Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative C

Virtual Maths - 3D shapes, diagram, area, volume
Diagram of 3D shapes with formula for calculating area (and volume)
Author(s): Leeds Metropolitan University

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Future energy demand and supply
When you consider that the global annual consumption of primary energy increased more than ten-fold during the 20th Century, the importance of planning future energy supply becomes clear. First published on Wed, 27 Jul 2011 as Author(s): Creator not set

Obesity: Balanced diets and treatment
The incidence of obesity is on the increase in affluent societies, and the phenomenon commands increasing attention from health professionals, legislators and the media. This unit looks at the science behind obesity, examining the dietary, physiological and genetic aspects of the topic. First published on Wed, 27 Jul 2011 as Author(s): Creator not set

Climate change
Human societies have to take urgent action to end their dependences on fossil fuels. We have to alter the whole path of our development and decision making in order to make our societies both environmentally adaptable and sustainable. This unit takes on the task of trying to chart some of the ways in which it might be possible. First published on We
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Biofuels
This unit investigates what is meant by a biofuel and covers the advantages of using biofuels compared to fossil fuels. The different types of biofuel are explored, with particular emphasis on transport biofuels. Finally, the issue of whether biofuels are the complete answer to our future energy needs is considered. First published on Wed, 27 Jul 2011 as Author(s): Creator not set

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Author(s): The Open University

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5.4 The medical chemistry strategy

The strategy adopted was to start from first principles. Since prazosin is an alpha1 antagonist, it must compete with the agonist, noradrenaline, for the alpha1 receptor. So the Pfizer scientists decided to compare the structures of the two molecules and look for common structural features that might provide an insight into the way in which they bind to the receptor. One important observation was the fact that, at physiological pH, both compounds would be protonated, nor
Author(s): The Open University

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5.3 Project initiation

In the early 1970s a discovery was made independently by two different researchers, Klaus Starke in Germany and Salomon Langer in Argentina. Their results showed that there were two types of alpha receptor. The first type, which they called alpha1 is the one already described that is found on the blood vessel wall. The second type, which they called alpha2, is located on the nerve-ending itself. Noradrenaline binds to the alpha2 receptors when the alpha
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5.1 The medical background

Blood pressure is normally tightly controlled in the face of large variations in blood flow required by activities such as vigorous exercise. The diameter of the blood vessels is under the influence of the so-called sympathetic nervous system. Impulses from the brain stimulate the release of a chemical substance, noradrenaline (1), from the nerve-endings close to the vessel walls. The noradrenaline then diffuses to the blood vessel wall, where it interacts with a specific molecular sit
Author(s): The Open University

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2 Video activity

The video clip included in this section looks at the development of one particular drug. It examines the complex multidisciplinary process that was involved in its discovery. Before you watch the video, read through the Pre-viewing notes.


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1 The chemical industry

The chemical industry is one of the major contributors to the economies of advanced industrial nations.

The importance of organic chemistry in the pharmaceutical industry becomes apparent in the light of the fact that in the UK alone some £2.2b was spent in 1997 on research and development. Literally thousands of different compounds have to be synthesised and tested in the search for the one that will prove to be a successful and valuable therapeutic agent. As a result, the average cos
Author(s): The Open University

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Acknowledgements

Except for third party materials and otherwise stated (see terms and conditions), this content is made available under a Creative Commons Attribution-NonCommercial-ShareAlike 2.0 Licence

Grateful acknowledgement is made to the following sources for permission to reproduce material in this unit:

Author(s): The Open University

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2.1 Chemical periodicity

The chemistry of the elements is immensely varied. But amidst that variety there are patterns, and the best known and most useful is chemical periodicity: if the elements are laid out in order of atomic number, similar elements occur at regular intervals.

The discovery of chemical periodicity is particularly associated with the nineteenth-century Russian chemist Dmitri Ivanovich Mendeléev (Figure 16). The periodicity is represented graphically by Periodic Tables. Author(s): The Open University

2.3.1 Structural isomerism

In the saturated hydrocarbons, whose structural formulae are shown in Figure 16, it is not possible to form distinct isomers with just three or less carbon atoms linked together. There is only one way in which one carbon and four hydrogen atoms can be linked together, the single compound being methane, CH4. A simila
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1.2 Ethical examples

But is this a tenable position? In other words, is it only the people who use the technologies who carry the ethical burden? Conversely, is ethics of any interest to engineers, programmers and scientists? What, in the first place, constitutes an ethical issue? To begin examining these questions, let's look at some examples.

Example 1: Th
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Objectives for Section 3

After studying this section you should be able to do the following.

  • Recognise and use the terminology: disjoint union; power set (of a set); representation (of a data abstraction).

  • Use and interpret the notation:

     

    • X
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