Molecular Classification - Prof. Chris Man (Part 2)
Recent advances in genomic and proteomic technologies have revolutionized our way of classifying diseases. These high-throughput technologies allow the development of powerful and multivariate classifiers to distinguish different diseases or tumors based on their molecular profiles. Molecular classification provides a new way to distinguish histologically similar but molecularly different types of tumors, and hence improves tumor diagnosis and prognosis. In this course, we introduce major concep
Multipolar representation of protein structure
Background That the structure determines the function of proteins is a central paradigm in biology. However, protein functions are more directly related to cooperative effects at the residue and multi-residue scales. As such, current representations based on atomic coordinates can be considered inadequate. Bridging the gap between atomic-level structure and overall protein-level functionality requires parameterizations of the protein structure (and other physicochemical properties) in a quasi-co
Methylphenidate Decreased the Amount of Glucose Needed by the Brain to Perform a Cognitive Task
The use of stimulants (methylphenidate and amphetamine) as cognitive enhancers by the general public is increasing and is controversial. It is still unclear how they work or why they improve performance in some individuals but impair it in others. To test the hypothesis that stimulants enhance signal to noise ratio of neuronal activity and thereby reduce cerebral activity by increasing efficiency, we measured the effects of methylphenidate on brain glucose utilization in healthy adults. We measu
Drawing Shadows to Stone: Photographing North Pacific Peoples
This Web site, created to complement an American Museum of Natural History exhibition, takes a look at an anthropological expedition to record the people and cultures of the North Pacific.
Paradise Redefined: Part 2
A journey to a coral reef chain hidden in the Central Pacific forces scientists to revisit the definition of a pristine environment. Part Two.
Obesity is Socially Contagious
Are your friends making you fat? Or keeping you slender? According to new research from Harvard and the University of California, San Diego, the short answer on both counts is "yes.”
NetMHCpan, a Method for Quantitative Predictions of Peptide Binding to Any HLA-A and -B Locus Protei
Background Binding of peptides to Major Histocompatibility Complex (MHC) molecules is the single most selective step in the recognition of pathogens by the cellular immune system. The human MHC class I system (HLA-I) is extremely polymorphic. The number of registered HLA-I molecules has now surpassed 1500. Characterizing the specificity of each separately would be a major undertaking. Principal Findings Here, we have drawn on a large database of known peptide-HLA-I interactions to develop a
Orchidaceae Morphology: Oncidium cultivar
Orchid morphology of Oncidium. Structures labeled include: petals; sepals; callus; column; column wings; stigma; pollinia and anther cap. Includes a dissection that removes the anther cap to expose the pollinia.
Open genius: strumento per una scienza libera
The presentation of the researcher Andrea Gaggioli about a new way to finance the scientific research: crowd funding. Le nuove tecnologie partecipative possono trasformare radicalmente la ricerca scientifica. Strumenti emergenti quali il crowdsourcing e il crowdfunding possono contribuire a rendendere la scienza un'impresa più aperta, trasparente e democratica. Questo intervento video esplora questi strumenti e introduce Open*Genius, una piattaforma 2.0 per aiutare i ricercatori a trovare le ri
Mice, Men, and Mental Illness: Animal Model of Human Mental Disorders
Mice, Men, and Mental Illness: Animal Model of Human Mental Disorders. Dr. Eric Kandel's lecture.
TRMM Rainmap for September 1998: Africa
Monthly average rainfall over Africa for September 1998 as measured by TRMM. High rainfall rates are in red.
TOMS Ozone at the South Pole: September Averages from 1979 through 2000
The year 2000s Antarctic ozone hole is the largest ever observed. Scientists continue to investigate the phenomenon, and are somewhat surprised by its scale. Using data from NASAs Total Ozone Mapping Spectrometer (TOMS) instrument onboard the Earth Probe satellite, researchers can evaluate and compare current conditions over the south pole to readings taken by other instruments in years past. Continued monitoring of polar ozone levels helps researchers gain a better understanding of how the plan
Pericardial pathology 900 years ago: A study and translations from an Arabic medical textbook
This is a study and translation of the section on pericarditis in Al Taisir book written by the Muslim physician Ibn Zuhr (Avenzoar) who lived and practiced in Eshbeelia (nowadays Seville, Andalusia,Spain) between 1091-1162 AD. Ibn Zuhr described the serous type of pericarditis as well as the pathological findings in fibrinous pericarditis. His description of the latter may also fit with the picture of chronic fibrous pericarditis. He also described acute purulent pericarditis and involvement of
Photonic Dipole Contours of Ferrofluid Hele-Shaw Cell (Two Magnet Non-Pole Video)
This investigation describes and demonstrates a novel technique for the visualization of magnetic fields. Two ferrofluid Hele-Shaw cells have been constructed to facilitate the imaging of magnetic field lines. We deduce that magnetically induced photonic band gap arrays similar to electrostatic liquid crystal operation are responsible for the photographed images and seek to mathematically prove the images are of exact dipole nature. This is the two magnet version with the non-pole sides mostly f
Predicting structural disorder and induced folding: From theoretical principles to practical applica
Lecture from the Women in Bioinformatics series on protein disorders. Sonia Longhi, Ph.D. Permanent Senior Scientist, Architecture et Fonction des Macromolécules Biologiques, Centre National De La Recherche Scientifique (CNRS), Marseille, France
Public Scientific Data Talk at NC Science Blogging Conference
Xan Gregg provides examples of studies where the absence of access to raw data has profound implications and argues that scientists should make their raw data available even before they publish their results.
Digital Images: From Satellites to the Internet
Students will learn about digital images and how satellites orbiting Earth send information and pictures to Earth over the Internet.
Space Sense is a game developed as part of the Windows to the Universe project. Players learn about the planets, galaxies and the universe by answering questions. Every question they answer correctly will boost their rocket toward its destination-leaving the Earth's atmosphere. Each question contains a 'Life Line' button for helpful clues and an 'Open a Link' button that will take users to web page that has information about the question.
"Right After That They Walked Out": Alice Wolfson Recalls the Origins of the CIO
John L. Lewis' dramatic walkout from the October 1935 American Federation of Labor (AFL) convention and the creation of the Committee for Industrial Organization (later the Congress of Industrial Organizations) that soon followed marked a new stage in labor's drive to organize industrial unions in depression-era America. Here Alice Dodge Wolfson, who was working as a stenographer in 1935, recalled her own contribution to the Lewis walkout and the creation of the CIO. Attending the October 1935 A
Jack - Crossword
A crossword based on the poem Jack which is on the leaving cert course.