M.E. Muller Institute for Microscopy
This website is a nice primer for those who are interested in atomic-level surface imaging of biological samples with atomic force microscopy (AFM). The accompanying graphics are illustrative of what can be done and at what resolution. Note the material is a little dated (1996), but is still very useful. If one is interested in learning about biological imaging with other methods as well, it is recommended to open the home page site (http://www.mih.unibas.ch/Booklet/Booklet96/Intro/Intro.ht
Theme-Based Modular Approach for Delivering the Undergraduate Analytical Curriculum
This paper from the ABCs of Teaching Analytical Science in the journal Analytical and Bioanalytical Chemistry describes the modifications to the analytical curriculum at Butler University. The laboratory associated with the course in Quantitative Analysis was retooled to include a series of projects emphasizing report-writing, data reduction/analysis, method development, method comparison, and a guided-inquiry capstone project. The laboratory for Instrumental Analysis is a semester-long module
This article by Peter Griffiths, published in the ABCs of Teaching Analytical Science series of the journal Analytical and Bioanalytical Chemistry, will be of interest to faculty members teaching analytical or quantitative analysis courses to chemistry, biochemistry, pre-health or natural science majors. Drawing from a survey of colleges and universities in the western United States, Griffiths summarizes how the quantitative analysis course is currently being taught, highlighting difference
Atomic Spectroscopy in a Project-Based Lab
An article published in the \"ABCs of Teaching Analytical Science\" series of the journal Analytical and Bioanalytical Chemistry describes a project-based lab in which students investigate the distribution of Pb and As (from pesticides) in a contaminated apple orchard. Students have complete control of the lab, from designing a sampling strategy to using the primary literature to develop procedures for extracting the analytes and for their subsequent analysis by ICP-AES or ICP-MS.
Receptor Binding Assays
A tutorial on receptor binding assays used in bioanalysis. Both scintillation proximity assays and measurements based on fluorescence polarization are discussed. This page also features a good bibliography on related resources.
A learning module focused on principles and practice of NMR for quantitative analysis, an application less commonly associated with the technique than is structure determination. Links to simulation packages are included.
Atomic Force Microscopy
A video lecture on Atomic Force Microscopy (AFM) by Prof. Arvind Raman of Purdue University that discusses the historical development, instrumentation and operational principles of various AFM modes. The lecture is accompanied by power point slides with clear illustrative graphics. Basics are provided in the application examples with advantages and limitation discussed. Useful site to those interested in learning AFM.
Population Genetics and Statistics
This website is part of the President\'s DNA Initiative and is devoted to past and current methods of macromolecules such as DNA. This website introduces the student to the subject of population genetics and stresses factors that can alter allele frequencies in a population and calculations associated with the Hardy-Weinberg principle. The student will learn to use acceptable statistical approaches to evaluating DNA data and how DNA databases are constructed and applied. This site is designed as
Fundamentals of NMR
This e-text presents an introduction to the fundamentals of NMR covering magnetic resonance, pulsed NMR, relaxation, chemical shift, spin-spin coupling, the nuclear Overhauser effect and chemical exchange.
NMR of Paramagnetic Proteins
This site presents an overview of techniques used for structural elucidation of paramagnetic metalloproteins. The content is directed to the more advanced NMR user and would be suitable for an upper division or graduate level NMR class.
This article describes the use of fluorine (19F) NMR for the analysis and structure determination of biomaterials. Using a traditional text-with-figures format, the article gives an overview of the synthesis of 19F spin-labeled materials and detailed descriptions of 19F chemical shifts and relaxation phenomena as applied to both primary and tertiary structure determinations of biochemical interest.
A Pictorial Representation of Product Operator Formalism: Non-Classical Vector Diagrams for Multidim
This site presents a pictorial description of the product operator formalism using a non-classical vector approach. This approach allows for the representation of any arbitrary multidimensional or heteronuclear NMR experiment. A description of a complete set of 16 vector representations for weakly-coupled two-spin (I=1/2) systems is given followed by an extension of this set to three-spin systems. Finally the concepts of coherence transfer, multiple quantum spectroscopy and phase cycling are ill
Tales of the Riverbank
This environmental PBL unit can be downloaded as a set of pdf\'s that include materials for students and an instructor\'s guide. These materials present a compelling environmental problem and analytical data that allow students to be educated as they work through the various tasks associated with identifying potential pollutants responsible for the reduction in fish within the Coley River. In addition, to providing the data necessary to solve the problem, the authors provide simple analytical sk
Amplified DNA Product Separaration for Forensic Analysts
This website is part of the President\'s DNA Initiative and is devoted to past and current methods of macromolecules such as DNA. This site reviews the analytical technologies of electrophoresis. Discussed are the differences between agarose and polyacrylamide electrophoresis. The basic principles of capillary electrophoresis and its advantages for conducting forensic DNA analysis are detailed. The site is designed as an on-line short course with excellent graphic support. The user must register
Physical Chemistry Online
Physical Chemistry Online (PCOL) Is a collection of physical chemistry modules that address specific concepts in an open-ended, collaborative fashion. The PCOL collection contains fifteen guided inquiry modules covering five broad topics: thermodynamics, kinetics, polymers, computational chemistry, and spectroscopy. Many modules provide the students with an industrial context auch as the evaluation of raw materials or the development of new products. Students that participate in these modules ar
This site provides an introduction to the use of multiple regression, beginning with a glossary of important terms before taking the reader through a review of bivariate regression and the implementation and interpretation of multiple regression. One limitation to the site is its reliance on Minitab for calculations. Users, however, can reproduce the calculations using other software packages, such as SPSS or Excel. Prior knowledge of the basics of bivariate regression is assumed; thus, the site
primer on microscopes
This website is sponsored by Olympus company. It is similar to two other sites (one by Florida State University, the other by Nikon) already in asdlib whereby a common group of authors contributed to the development of all three sites. Thus, these sites are similar in content although differences exist. This Olympus site has a \"virtual microscopy\" that contains links to interacdtive tutorials that demonstrate the operation of different types of microscopes. Thus, one can compare how various
Concepts, Instrumentation and Techniques in Atomic Absorption Spectrophotometry
This pdf file contains a well written and thorough introduction to atomic absorption suitable for use by undergraduates and faculty teaching instrumental analysis courses. Topics covered in the document include theoretical concepts and definitions, flame atomic absorption, instrumentation, analytical interferences, sampling techniques, graphite furnace atomic absorption, and plasma techniques.
Virtual Crime Scene-Autopsy of a Murder
This site is designed to explore the interaction of crime scene investigation and forensic science Visitors are taken to a crime site where a murder took place. Relevant items of physical evidence are identified and the viewer is allowed to transport each item into a virtual crime. In the laboratory the viewer is allowed to select the appropriate technology to examine the selected item of evidence. Explanations are provided to educate the viewer on the theory and applications of a variety of for
Handbook of Basic Atomic Spectroscopic Data
This National Institute of Standards and Technology (NIST)) site containing atomic spectroscopic reference data. Information can be accessed through a variety of means, such as an interactive periodic table and dropdown lists of elements organized by name or atomic number. Data available include isotope abundance, electron configuration, nuclear spin, magnetic moment, ionization energies, spectral line wavelengths and intensities, and energy level information. References are also given.