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1.5 Signal transduction mechanisms

Signalling information has to be transmitted from the receptor in the plasma membrane across the cytoplasm to the nucleus (if gene transcription is the response), the cytoskeleton (if cell movement, or another change to cell morphology, is the response), or various other subcellular compartments. The transmission of a signal must occur in a time-frame appropriate for the cellular response. So, signal transduction needs to take place over both space and time. We have already described a simple
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Billy Collins & Karen Romagna: 2014 National Book Festival
Billy Collins and Karen Romagna appear at the 2014 Library of Congress National Book Festival in Washington, D.C. Speaker Biography: Karen Romagna loves the ocean so much that as a little girl she decided she would be a mermaid. That didn't work out. Instead she followed her other love, art. Mainly a self-taught artist, Karen lives and paints in historic Clinton, N.J. with her family. They vacation every year at the Jersey Shore, where Karen spends most days on the beach painting, hoping to on
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About Greek Theater
Greek theater began in the 6th century B.C., and it has become a cornerstone in the performing arts. Understand the history of acting through the study of Greek theater. (1:40)
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France goes to polls with National Front in ascendancy
Voting begins in the first round of French local elections, as the anti-immigration National Front hopes to consolidate leader Marine Le Pen's bid for the presidency in 2017. Pavithra George reports. Subscribe: http://smarturl.it/reuterssubscribe More updates and breaking news: http://smarturl.it/BreakingNews Reuters tells the world's stories like no one else. As the largest international multimedia news provider, Reuters provides coverage around the globe and across topics including business,
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Expertise of the Architect
One of the areas where the expertise of the seasoned architect comes out is in the initial structuring of design problems. During problem structuring the parameters and processes used in design are defined. Experienced architects modify these parameters both in global and local levels as a function of the success of their research process. Experienced architects also rely on 'scenarios' acquired through pervious experiences with similar problems to initialize their problem structures or to redef
Author(s): Akin, Omer

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‘Makers’: Chris Anderson on DIY Manufacturing
Just as the Internet enabled anyone with a computer to become an entrepreneur, today's newest technologies have spawned a DIY (do it yourself) micro-manufacturing movement, so anyone can be both inventor and manufacturer. Wired editor Chris Anderson, author of the new book, Makers: The New Industrial Revolution, recently spoke with Knowledge@Wharton about how technology is changing the limits of what inventors can do, what the Maker Movement is, why he started DIY Drones and ho
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The Rhubarb Triangle
This is an interactive learning resource book targeted at families who want to learn together and improve their basic English and maths abilities.
Author(s): Davis, Samantha

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Asia and the Pacific Policy Society (APPS) Conference 2014 - Daniel Sloper
Daniel Sloper is a panelist for the G20 policy challenges discussion at the Asia and the Pacific Policy Society (APPS) Conference 2014 at Crawford School of Public Policy. Daniel Sloper is a G20 Special Representative, First Assistant Secretary, G20 and International Economy Branch, DFAT. This year's conference focused on the G20 agenda to support the Australian government and its hosting of the G20 leaders' meeting later in 2014. The Asia and the Pacific Policy Society Conference 2014 brings
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2.11.1 Revision: choosing and booking hotels

In this session, you will revise choosing and booking hotel rooms, understanding directions, identifying and using dates (years).

Activité 56

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3.5 A new life

There is a common belief that life begins at the moment of conception, i.e. when a sperm fuses with an egg. This is a step forward from past years, when life was alleged to start at the time of ‘quickening’, i.e. when a woman could feel her fetus moving inside her. However, both these opinions suffer from an underlying falsehood: that life ‘begins’ at all. Life is a continuum; gametes are produced by living parents, and fuse to produce new living individuals, but unfused gametes are n
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E-Portfolio Toolkit - Booklet
This E-Portfolio Toolkit is based on experience of developing the “Year Abroad E-Portfolio”, undertaken by the School of Languages at Leeds Metropolitan University. We use an E-Portfolio to assess our students on their period abroad because we think it encourages them to fully engage with culture(s) and language of the target country and to reflect on the resulting cultural and linguistic development. As part of our project, we have also developed a set of learning activities and materials,
Author(s): Mara Fuertes-Gutiérrez,Juan Muñoz López,Janet P

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Knut Drescher lecture 2.11.14
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7.1 The ascending auditory pathway

Up till now we have dealt with the anatomy of the auditory periphery and how the basic attributes of sound are coded within the auditory periphery. A great deal of additional processing takes place in the neural centres that lie in the auditory brainstem and cerebral cortex. Because localisation and other binaural perceptions depend on the interaction of information arriving at the two ears, we need to study the central auditory centres, since auditory nerves from the two cochleae interact on
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4.8 General equation of a conic

You have already met the parabola, ellipse and hyperbola. So far, you have considered the equation of a conic only when it is in standard form; that is, when the centre of the conic (if it has a centre) is at the origin, and the axes of the conic are parallel to the x- and y-axes. However, most of the conics that arise in calculations are not in standard form.

We have seen that any circle can be described by an equation of the form

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Characteristics of Bodies of Water
In this brief video clip, students learn about the characteristics of different bodies of water including rivers and streams, lakes and ponds, waterfalls, wetlands and oceans. Transcript: Over two-thirds of the earth's surface is covered in water. Today's lesson will explore the different places that water can be found and the different ways it can look. this video clip addresses fresh water.  Run time 0:54.

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3.5.4 Other modes

The investigation of new scanning modes for the AFM has been something of a playground for researchers: think of any interaction between materials in which a force plays a part and you have a potential scanning mode. Coating the probe with a magnetic material, appropriately magnetised, enables samples to be scanned in magnetic-force mode. An obvious industrial use for this technique is the investigation of the structure of magnetic storage media. Electrostatic forces too have been used. Using
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4.1 What is a data flow diagram?

A data flow diagram (DFD) is a graphical description of the ebb and flow of data in a given context. A DFD allows you to identify the transformations that take place on data as it moves from input to output in the system. (DFDs pre-date UML diagrams, but still have a complementary role to play in describing systems.)

The Case Study below provides an example of a DFD used to describe the Open University's eTMA system (electronic Tutor Marked Assignment system). It uses the
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Klasactiviteit over Nederland
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Weetjes over Nederland en de koninklijke familie met invuloefeningen en in eenvoudig Nederlands.


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Introduction

Earthquakes shake the ground surface, can cause buildings to collapse, disrupt transport and services, and can cause fires. They can trigger landslides and tsunami – in short, earthquakes can be very destructive. In this unit you will look at why, where and what happens when they occur and also at how earthquakes are assessed qualitatively and quantitatively.

This unit is from our archive and is an adapted extract from Exploring science (S104) which is no longer taught by The Open Uni
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Except for third party materials and/or otherwise stated (see terms and conditions) the content in OpenLearn is released for use under the terms of the Creative Commons Attribution-NonCommercial-Share

Episode as a Unit of Analysis of Movement
Everybody who has read his Gordon Cullen or his Edmund H. Bacon knows that movement has long been recognized as a factor in environmental planning in many ways. For example, in the traditional Japanese promenade garden the importance of movement has always been appreciated. The promenader gains an intense experience of the succession, variation and rhythm of the surrounding scene. The spaces and paths lead him from one stage to another. The spatial structure of the Japanese promenade garden, as
Author(s): Aura, Seppo

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