Publications Representative of our Research

(several other publication listings can be found under - Research Overview & More Details)

Davis, S. et al. (2015) Alpha-tocopherols Modify the Membrane Dipole Potential Leading to Modulation of Ligand Binding by P-glycoprotein. Journal of Lipid Research . jlr.M059519. doi:10.1194/jlr.M059519

Richens, J. L., et al. (2015).The electrical interplay between proteins and lipids in membranes. Biochimica et Biophysica Acta (BBA)-Biomembranes.DOI information: 10.1016/j.bbamem.2015.03.017

Richens, J. L., Lunt, E. A., & O'Shea, P. (2015). Optimisation of protein microarray techniques for analysis of the plasma proteome: Minimisation of non-specific binding interactions. Immunopharmacology. 24: 166–168 pdf here:

O’Shea, P. (2014)  Occult  Physiology: Electrical Cross-Talk between Membrane Lipid, Occluded Ions, and the Na-K ATPase, Biophysical Journal 107: 1257–1258

Lane J. S. et al. (2014) Rational Targeting of Sub-Classes of Intermolecular Interactions: Elimination of Nonspecific Binding for Analyte Sensing. Langmuir 30: 9457–9465. DOI: 10.1021/la5016548  PDF here:

Richens J.L. et al (2014) Practical detection of a definitive biomarker panel for Alzheimer’s disease; comparisons between matched plasma and cerebrospinal fluid. Int J Mol Epidemiol Genet 5: 53-70. available here (open access)

Davis, B.M., et al (2014) Topical Delivery of Avastin to the Posterior Segment of the Eye In Vivo Using Annexin A5-associated Liposomes. Small. 10: 1575-1584. doi: 10.1002/smll.201303433

Richens, J. L., Morgan, K., & O’Shea, P. (2014). Reverse engineering of Alzheimer’s Disease based on biomarker pathways analysis. Neurobiology of Aging. 35: 2029-2038 ( ) pdf here

Richens, J. L. & O’Shea, P. (2014) Next Generation techniques for biomedical imaging in Biomedical imaging: Applications and advances (Morris, P ed) see DOI: 10.1533/9780857097477.1.65 .. pdf here

Wang, J et al (2014) Highly sensitive multipoint real-time kinetic detection of Surface Plasmon bioanalytes with custom CMOS cameras Biosensors and Bioelectronics 58: 157–164 (

Murray, E et al (2014) Targeting Staphylococcus aureus quorum sensing with non-peptidic small molecule inhibitors. Journal of Medicinal Chemistry 57: 2813–2819(DOI: 10.1021/jm500215s)

Bodhicharla R. et al (2013) Effects of α-synuclein overexpression in transgenic Caenorhabditis elegans strains.CNS Neurol Disord Drug Targets. 11: 965-75 available here

Vere, K., et al (2013) Evidence for sodium metasilicate receptors on the human osteoblast cell surface; spatial localization and binding properties. Molecular Membrane Biology 30: 386-393 (doi:10.3109/09687688.2013.843031)

Seddon, J. et al (2013) Lipids and Membrane Biophysics . Faraday Discussions No. 161 details here and available here or from Amazon here

Richens, J. et al (2013) The Future Role of Biomarkers in Alzheimer’s Disease Diagnostics.pp 231-248 in Genetic Variants in Alzheimer's Disease. (Eds Morgan, K., & Carrasquillo, M) Springer Science & Business.

Vankemmelbeke, al. (2012) Interaction of Nuclease Colicins with Membranes: Insertion Depth Correlates with Bilayer Perturbation. PLoS ONE : e46656. doi:10.1371/journal.pone.0046656 available here

Powell K.J., Sharma, P., Richens. J.L., Davis. B.M., Moses, J.E. & O'Shea, P. (2012) ) Interactions of marine-derived γ-pyrone natural products with phospholipid membranes Phys. Chem. Chem. Phys., 14, 14489-14491 available here

Vere K, Richens J, Somekh M, Bajaj N, Morgan K, O’Shea P. (2012) Plasmonic-array-based biosensors for the diagnosis of neurodegenerative diseases. IEEE. DOI:10.1109/FOI.2011.6154818.

Ciesielski F. et al (2012) Receptor-independent interaction of bacterial lipopolysaccharide with lymphocyte membranes; the role of cholesterol PLoS ONE PONE- DOI:10.1371/journal.pone.0038677 - PDF available here

O’Shea, P. (2012) Future medicine shaped by an interdisciplinary new biology The Lancet, 379: 1544 - 1550,

Robinson D, et al (2011) Di-8-ANEPPS Emission Spectra in Phospholipid/Cholesterol Membranes: A Theoretical Study. Journal of Physical Chemistry B. 115: 4160-4167. available as a pdf here

Davis, B.M, Richens, J. & O'Shea, P. (2011) Label-Free Critical Micelle Concentration Determination of Bacterial Quorum Sensing Molecules Biophysical Journal, 101: 245-254 available online here

Richens, J.; Vere, K. & O'Shea, P. (2011) Optimisation of plasmonic-based biosensors for label-free imaging of molecular arrays; towards diagnosis of neurodegenerative diseases. IEEE. DOI: 10.1109/FOI.2011.6154819

Robinson D, et al. (2011) Water Order Profiles on Phospholipid / Cholesterol Membrane Bilayer Surfaces. Journal of Computational Chemistry 32: 2613-2618 available as a pdf here

Smith, R. et al (2011) Development of a robust wide field surface plasmon instrument as part of a platform for Alzheimer's disease diagnosis. IEEE. DOI: 10.1109/FOI.2011.6154822

Davis, B.M. et al (2010) The Interaction of N-Acylhomoserine Lactone Quorum Sensing Signaling Molecules with Biological Membranes: Implications for Inter-Kingdom Signaling. PLoS One : Open Access available online here:

Richens, J. et al. (2010) Quantitative Validation and Comparison of Multiplex Cytokine Kits. Journal of Biomolecular Screening. 15: 562-568 available online here

Richens, J. et al. (2010) In vivo spectroscopic imaging of biological membranes & surface imaging for high-throughput screening. In Nanoscopy & Multidemsional Optical fluorescence Mircoscopy. A Diaspro et al (Ed). Taylor & Francis CRC Press, USA. available online here

Richens, J. et al. (2009) Avoiding Nonspecific Interactions in Studies of the Plasma Proteome: Practical Solutions to Prevention of Nonspecific Interactions for Label-Free Detection of Low-Abundance Plasma Proteins. Journal of Proteome Research. 8: 5103–5110 available online here

Robinson, D et al (2009) Calculating the fluorescence of 5-hydroxytryptophan in proteins Journal of Physical Chemistry B. 113: 14521–14528. available online here

Lunt E.A.M. et al (2009) Quantitative studies of the interactions of metalloproteins with gold nanoparticles: identification of the dominant properties of the protein that underlies spectral changes. Langmuir .25: 10100-10116 available online here

Richens, J et al (2009) Systems biology coupled with high-throughput screening as a novel approach for diagnosis of Chronic Obstructive Pulmonary Disease (COPD). Respiratory Research 22: 10-29 available here

O'Shea, P (2009) Membrane potentials in living systems. The Wiley Encyclopaedia of Chemical Biology. John Wiley & Sons. Inc. whole volume available here and article as a pdf. here

Robinson, D. et al (2009) Electronic structure of 5-Hydroxyindole; from gas-phase to explicit solvation. Journal of Physical Chemistry B. 113, 2535-2541. available online here

Richens, J. L. & O'Shea, P. (2009). Chaotropic agents to prevent non-specific binding in proteomics and micro-array technologies. UK Patent Application no. GB0905293.7

Lunt, E.A.M., Pitter, M.C., Somekh, M.G. & O’Shea, P. (2008) Studying Protein Binding to Conjugated Gold Nanospheres; Application of Mie Light Scattering to Reaction Kinetics J. Nanosci. Nanotechnol. 8, 4335–4340

Duggan, J., et al. (2008) Functional imaging of microdomains in cell membranes . European Biophysics Journal. 37: 1279-1289 available online here

O'Shea, P., Somekh, M.G. & Barnes, W.L. (2008) Shedding light on life; visualising nature's complexity. Physics World. 21: 29-34 available online and here

Brunaldi, K., et al. (2007) Fluorescence assays for measuring Fatty Acid binding and transport through membranes. Methods Mol Biol. 400: 237-256 available here

O'Shea, P. (2007) Membrane Potentials and Membrane Probes In Chemical Biology (Eds: Larijani et al. ) John Wiley & Sons, Ltd pages 67-84- available online

Richardson, G., Cummings, L.J., Harris, H. & O'Shea, P. (2007) Towards a mathematical model of the assembly and disassembly of membrane microdomains: comparison with experimental models Biophysical Journal 92: 4145-4156 ... pdf available online and here

Rigby-Singleton, S. et al. (2006) Visualizing the Solubilization of Supported Lipid Bilayers by an Amphiphilic Peptide. Langmuir 22, 6273 -6279 . pdf

Qazi, S. et al. (2006) N-Acylhomoserine Lactones Antagonize Virulence Gene Expression and Quorum Sensing in Staphylococcus aureus. Infection and Immunity 74, 910-919

Goh, J. et al. (2005) Two-photon fluorescence surface wave microscopy. Journal of Microscopy, 220 168-175. ......... pdf

Rogers, D. et al. (2005) Modeling the Absorption Spectrum of Tryptophan in Proteins. Journal of Physical Chemistry B, 109, 23061-23069 ......... pdf

O'Shea, P. (2005) Physical landscapes in biological membranes. Philosophical Transactions of the Royal Society: Mathematical, Physical and Engineering Sciences 363, 575-588- available online

Sim, B., Cladera, J. & O'Shea, P. (2004) Fibronectin interactions with osteoblasts; identification of a non-integrin-mediated binding mechanism using a novel real-time fluorescence binding assay Journal of Biomedical Materials Research - 68, 352 - 359

O'Shea, P. (2004) Membrane Potentials; measurement, occurrence & roles in cellular function pp 23-59 in Bioelectrochemistry of Membranes (D. Walz et al. Eds) Birkhauser Verlag, Switzerland - click link to inspect

Somekh, M & O.Shea, P.(2003) Inside the Cell ; a new microscopy. general article in Vision magazine

Allen, S., Rigby-Singleton, S.M., Harris, H., Davies M.C. & O'Shea, P. (2003) Measuring and visualizing single molecular interactions. Biochemical Society Transactions. 31, 1052–1057

Valenta, C., et al (2003) Influence of membrane Molecular Dipoles on Human Skin Permeability: use of 6-Ketocholestanol to Enhance the Transdermal Delivery of Bacitracin.Journal of Pharmaceutical Sciences 92:1018-1027

O'Shea, P. (2003) Intermolecular Interactions with/within Cell Membranes and the Trinity of Membrane Potentials; kinetics & imaging. Biochemical Society Symposium - 31. 990-996.

Cladera, J. & O'Shea, P. (2002) Influence of the membrane dipole potential on the interaction of macromolecules with biomembranes. Biofisica Molecular 53. 23-33.

Georgiou, G., et al (2002) Measurement of the Lateral Diffusion of Human MHC Class I Molecules on HELA Cells By Fluorescence Recovery After Photobleaching Biophysical Journal 82 1828-1834

Asawakarn, T., Cladera, J. & O'Shea, P. (2001) Effects of the membrane dipole potential on the interaction of Saquinavir with phospholipid membranes and plasma membrane receptors of Caco2 cells. Journal of Biological Chemistry. 276, 38457-38463

Cladera, J. & O'Shea, P. (2001) Generic techniques for fluorescence measurements of protein-ligand interactions; real-time kinetics & spatial imaging. pp. 169-200. In Protein-Ligand Interactions. Harding & Chowdery (eds.) Oxford University Press. UK.

Cladera, J., Martin, I. & O'Shea, P. (2001) The fusion domain of HIV gp41 interacts specifically with heparan sulfate on the T-lymphocyte cell surface. EMBO Journal 20. 19-26.

Valenta, C., Cladera, J., O'Shea, P & Hadgraft, J. (2001). Effect of phloretin on the percutanoeus absortion of lignocaine across human skin. Journal of Pharmaceutical Sciences 90, 485-492

Harris, R. & O'Shea, P. (2001) Compounds and use thereof to modify (inhibit or promote) transport across cell membranes - International Patent - Patent Cooperation Treaty (PCT) Publication No. WO 01/46223 A1

Swithenby, M. & O'Shea, P. (2001) Membranes and Transport. In The Core of Life (ed. J. Saffrey) Chapter 3 - pp 107-164 The Open University Press. - ISBN 0 7492 97492

Wolfe, C.A., Cladera, J., Lahda, S., Senior, S., Jones, R. & O'Shea, P. (1999) Membrane interactions of the putative fusion peptide (MFa P) from Fertilin-a the sperm protein complex involved in fertilization. Molecular Membrane Biology 16. 257-263.

Cladera, J., Martin, I., Ruysschaert, J-M, & O'Shea, P. (1999) Characterization of the Sequence of Interactions of the Fusion Domain of the Simian Immunodeficiency Virus with Membranes; Role of the Membrane Dipole Potential. Journal of Biological Chemistry 274. 29951-29959.

Chadborn, N., Bryant, J., Bain, A. & O’Shea, P. (1999) Ligand-dependent conformational equilibria of Serum Albumin revealed by tryptophan fluorescence quenching. Biophysical Journal 76. 2198-2207.

Cladera, J. & O’Shea, P. (1998) Intramembrane dipoles affect the membrane insertion and folding of a model amphiphilic peptide. Biophysical Journal 74. 2434-2442.

Wolfe, C.A., Cladera, J. & O'Shea, P. (1998) Amino acid sequences which promote and prevent the binding and membrane insertion of surface-active peptides: comparison of melittin and promelittin. Molecular Membrane Biology 15. 221-227

O’Shea, P. & Quadrant Healthcare UK Ltd. (1999) anti-HIV treatment based on competitive ligand interactions. Patent No. WO 9936092. The UK Patent Office, Department of Trade & Industry.