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Simon Langley-Evans

Professor of Human Nutrition, Faculty of Science

Personal Details
Administrative Responsibilities
Teaching and Learning
Research
Publications

Contact

workRoom C19 Main Building
Sutton Bonington Campus
Sutton Bonington
Leicestershire
LE12 5RD
UK
work0115 951 6139
Simon.Langley-evans@nottingham.ac.uk

Biography

Professor Simon Langley-Evans graduated from the University of London in 1986 with a first class honours degree in Biochemistry with Microbiology. He studied for his PhD in the Department of Human Nutrition at the University of Southampton, under the supervision of Dr David York. He graduated in 1990 and after a period of postdoctoral work at both Southampton and the United Medical and Dentist School in London he obtained a Wellcome Trust Career Development Fellowship. He has subsequently held lectureship positions at the University of Southampton, University College Northampton and University of Nottingham.

Professor Langley-Evans was awarded a personal Chair in Human Nutrition in 2005. His research expertise lies in the area of the Developmental Origins of Adult Disease, where he has conducted pioneering work in the development of experimental models of nutritional programming. He is the author of over 140 peer reviewed papers and in 2009 published an undergraduate textbook entitled, "Nutrition: A Lifespan Approach." The second edition, "Nutrition, Health and Disease" was published in 2015 and the third edition was published in August 2021. In 2005 he was awarded the Nutrition Society Silver Medal and in 2012 received his DSc from the University of Nottingham. Professor Langley-Evans is the Editor of the Journal of Human Nutrition and Dietetics.

Teaching Summary

Research Summary

Selected Publications

LLOYD, L.J., LANGLEY-EVANS, S.C. and MCMULLEN, S., 2012. Childhood obesity and risk of the adult metabolic syndrome: a systematic review International Journal of Obesity. 36(1), 1-11
MCGIVERON, A., FOSTER, S., PEARCE, J., TAYLOR, M. A., MCMULLEN, S. and LANGLEY-EVANS, S. C., 2015. Limiting antenatal weight gain improves maternal health outcomes in severely obese pregnant women: findings of a pragmatic evaluation of a midwife-led intervention JOURNAL OF HUMAN NUTRITION AND DIETETICS. 28, 29-37
DANIEL Z, SWALI A, EMES R and LANGLEY-EVANS SC, 2016. The effect of maternal undernutrition on the rat placental transcriptome: protein restriction up-regulates cholesterol transport. Genes & nutrition. 11, 27
DANIEL ZC, AKYOL A, MCMULLEN S and LANGLEY-EVANS SC, 2014. Exposure of neonatal rats to maternal cafeteria feeding during suckling alters hepatic gene expression and DNA methylation in the insulin signalling pathway. Genes & nutrition. 9(1), 365

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Professor Langley-Evans is the Deputy Researcher Academy Lead for the Faculty of Science.

Professor Langley-Evans external roles include:

Editor-in-Chief of the Journal of Human Nutrition and Dietetics

In the last few years Professor Langley-Evans has been a member of the Nutrition Society Council , the BBSRC Pool of Experts (and Committee RMA member) and the Medical Research Council College of Experts. He was a member of the RERAD Mid Programme Review Panel for the Scottish Government, 2008-2009.

Professor Langley-Evans has over 20 years experience of undergraduate teaching experience. He is not teaching during his tenure as Head of School of Biosciences (ends October 2021, followed by a period of sabbatical leave). He has been an assessor for the Association for Nutrition course accreditation scheme and has been an external examiner for undergraduate and PGT courses at the University of Sheffield, Robert Gordon University and the University of Plymouth.

Current Research

Professor Langley-Evans' research focuses on the early life origins of adult disease. A wide range of epidemiological evidence suggests that there is a strong and significant relationship between impairment of fetal growth and risk of coronary heart disease, hypertension and non-insulin-dependent diabetes in later life. The work in the Langley-Evans laboratory has focused on the contribution of maternal nutritional status to this programming of adult disease risk. Manipulation of the protein content, amino acid composition or fatty acid balance within the diets of pregnant rats has been demonstrated to induce lifelong hypertension in their offspring and to establish a wide range of physiological and metabolic abnormalities. Professor Langley-Evans current work in this area focuses on the elucidation of molecular and physiological mechanisms that underpin the association between maternal nutrition and altered functions in the adult offspring.

Orcid ID: orcid.org/0000-0002-1969-8416

Broad research areas

Early life origins of disease

Pregnancy nutrition

Animal models of healthy ageing

Infant feeding

Obesity and the metabolic syndrome

SWIFT JA, LANGLEY-EVANS SC, PEARCE J, JETHWA PH, TAYLOR MA, AVERY A, ELLIS S, MCMULLEN S and ELLIOTT-SALE KJ, 2017. Antenatal weight management: Diet, physical activity, and gestational weight gain in early pregnancy. Midwifery. 49, 40-46
GATES L, LANGLEY-EVANS SC, KRAFT J, LOCK AL and SALTER AM, 2017. Fetal and neonatal exposure to trans-fatty acids impacts on susceptibility to atherosclerosis in apo E*3 Leiden mice. The British journal of nutrition. 117(3), 377-385
TARLING EJ, SALTER AM and LANGLEY-EVANS SC, 2016. Maternal high-fat feeding in pregnancy programs atherosclerotic lesion size in the ApoE*3 Leiden mouse. Journal of developmental origins of health and disease. 1-8 (In Press.)
PIJACKA W, CLIFFORD B, WALAS D, TILBURGS C, JOLES JA, MCMULLEN S and LANGLEY-EVANS SC, 2016. OS 11-04 Impact of gonadectomy on sympatho-vagal balance in male and female normotensive rat. Journal of hypertension. 34 Suppl 1, e75
SWIFT JA, PEARCE J, JETHWA PH, TAYLOR MA, AVERY A, ELLIS S, LANGLEY-EVANS SC and MCMULLEN S, 2016. Antenatal Weight Management: Women's Experiences, Behaviours, and Expectations of Weighing in Early Pregnancy. Journal of Pregnancy. 2016, 8454759
DANIEL Z, SWALI A, EMES R and LANGLEY-EVANS SC, 2016. The effect of maternal undernutrition on the rat placental transcriptome: protein restriction up-regulates cholesterol transport. Genes & nutrition. 11, 27
AVERY A, LANGLEY-EVANS SC, HARRINGTON M and SWIFT JA, 2016. Setting targets leads to greater long-term weight losses and 'unrealistic' targets increase the effect in a large community-based commercial weight management group. Journal of human nutrition and dietetics : the official journal of the British Dietetic Association. 29(6), 687-696
PIJACKA W, CLIFFORD B, WALAS D, TILBURGS C, JOLES JA, MCMULLEN S and LANGLEY-EVANS SC, 2016. Impact of gonadectomy on blood pressure regulation in ageing male and female rats. Biology of sex differences. 7, 64
WARE S, VOIGT J and LANGLEY-EVANS SC, 2015. Body composition and behaviour in adult rats are influenced by maternal diet, maternal age and high-fat feeding. Journal of nutritional science. 4, e3
MCGIVERON, A., FOSTER, S., PEARCE, J., TAYLOR, M. A., MCMULLEN, S. and LANGLEY-EVANS, S. C., 2015. Limiting antenatal weight gain improves maternal health outcomes in severely obese pregnant women: findings of a pragmatic evaluation of a midwife-led intervention JOURNAL OF HUMAN NUTRITION AND DIETETICS. 28, 29-37
PIJACKA W, CLIFFORD B, TILBURGS C, JOLES JA, LANGLEY-EVANS SC and MCMULLEN S, 2015. Protective role of female gender in programmed accelerated renal aging in the rat. Physiol Reports. 3, e12342
CHALASHIKA, P., LANGLEY-EVANS, S. C., SWIFT, J. A. and MELLOR, D. D., 2015. Preliminary analysis of the Botswana Infant Feeding Study: Prevalence of wasting, stunting and underweight, and formula feeding in HIV-exposed infants PROCEEDINGS OF THE NUTRITION SOCIETY. 74(OCE5), E338-E338
WARNEKE W, KLAUS S, FINK H, LANGLEY-EVANS SC and VOIGT J, 2014. The impact of cafeteria diet feeding on physiology and anxiety-related behaviour in male and female Sprague-Dawley rats of different ages. Pharmacology, biochemistry, and behavior. 116, 45-54
DANIEL ZC, AKYOL A, MCMULLEN S and LANGLEY-EVANS SC, 2014. Exposure of neonatal rats to maternal cafeteria feeding during suckling alters hepatic gene expression and DNA methylation in the insulin signalling pathway. Genes & nutrition. 9(1), 365
WHITEHEAD KA, LANGLEY-EVANS SC, TISCHLER VA and SWIFT JA, 2014. Assessing communication skills in dietetic consultations: the development of the reliable and valid DIET-COMMS tool. Journal of human nutrition and dietetics : the official journal of the British Dietetic Association. 27 Suppl 2, 321-32
LANGLEY-EVANS SC, 2014. Publishing in the Journal of Human Nutrition and Dietetics: tougher but more rewarding. Journal of human nutrition and dietetics : the official journal of the British Dietetic Association. 27(4), 309-10
MCGIVERON A, FOSTER S, PEARCE J, TAYLOR MA, MCMULLEN S and LANGLEY-EVANS SC, 2014. Limiting antenatal weight gain improves maternal health outcomes in severely obese pregnant women: findings of a pragmatic evaluation of a midwife-led intervention. Journal of human nutrition and dietetics : the official journal of the British Dietetic Association.
LANGLEY-EVANS SC, 2014. Nutrition in early life and the programming of adult disease: a review. Journal of human nutrition and dietetics : the official journal of the British Dietetic Association. (In Press.)
WRIGHT TM, KING MV, DAVEY WG, LANGLEY-EVANS SC and VOIGT JW, 2014. Impact of cafeteria feeding during lactation in the rat on novel object discrimination in the offspring. The British journal of nutrition. 112, 1933-7
LANGLEY-EVANS, S. C., 2014. Publishing in the Journal of Human Nutrition and Dietetics: tougher but more rewarding JOURNAL OF HUMAN NUTRITION AND DIETETICS. 27(4), 309-310
WRIGHT, THOMAS M., KING, MADELEINE V., DAVEY, WILLIAM G., LANGLEY-EVANS, SIMON C. and VOIGT, JOERG-PETER W., 2014. Impact of cafeteria feeding during lactation in the rat on novel object discrimination in the offspring BRITISH JOURNAL OF NUTRITION. 112(12), 1933-1937
KOUVELIOTI, R., VAGENAS, G. and LANGLEY-EVANS, S., 2014. Effects of exercise and diet on weight loss maintenance in overweight and obese adults: a systematic review JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS. 54(4), 456-474
LANGLEY-EVANS SC and MORAN VH, 2014. Childhood obesity: risk factors, prevention and management. Maternal & child nutrition. 10(4), 453-5
BURDEN S, LANGLEY-EVANS S and TALLEY N, 2014. Coeliac disease: pathogenesis, prognosis and management. Journal of human nutrition and dietetics : the official journal of the British Dietetic Association. 27(3), 203-4
BURDEN S, LANGLEY-EVANS S, POUNDER R and TALLEY N, 2014. Editorial: coeliac disease - pathogenesis, prognosis and management. Alimentary pharmacology & therapeutics. 39(6), 555-6
PEARCE J, TAYLOR MA and LANGLEY-EVANS SC, 2013. Timing of the introduction of complementary feeding and risk of childhood obesity: a systematic review. International journal of obesity. 37(10), 1295-1306
PEARCE J and LANGLEY-EVANS SC, 2013. The types of food introduced during complementary feeding and risk of childhood obesity: a systematic review. International journal of obesity. 37(4), 477-85
LANGLEY-EVANS SC, 2013. Fetal programming of CVD and renal disease: animal models and mechanistic considerations. The Proceedings of the Nutrition Society. 72(3), 317-25
ALTOBELLI, GIOIA, BOGDARINA, IRINA G., STUPKA, ELIA, CLARK, ADRIAN J. L. and LANGLEY-EVANS, SIMON, 2013. Genome-Wide Methylation and Gene Expression Changes in Newborn Rats following Maternal Protein Restriction and Reversal by Folic Acid PLOS ONE. 8(12),
LLOYD, L.J., LANGLEY-EVANS, S.C. and MCMULLEN, S., 2012. Childhood obesity and risk of the adult metabolic syndrome: a systematic review International Journal of Obesity. 36(1), 1-11
AKYOL, A., MCMULLEN, S. and LANGLEY-EVANS, S.C., 2012. Glucose intolerance associated with early life exposure to maternal cafeteria feeding is dependent upon post-weaning diet British Journal of Nutrition. 107(7), 964-978
SWALI, A., MCMULLEN, S., HAYES, H., GAMBLING, L., MCARDLE, H.J. and LANGLEY-EVANS, S.C., 2012. Processes underlying the nutritional programming of embryonic development by iron deficiency in the rat PLoS ONE. 7(10), e48133
LANGLEY-EVANS SC, ALEXANDER B, MCARDLE HJ and SLOBODA DM, 2012. Developmental origins of health and disease. Journal of nutrition and metabolism. 2012, 838640
ENGEHAM S, MDAKI K, JEWELL K, AUSTIN R, LEHNER AN and LANGLEY-EVANS SC, 2012. Mitochondrial respiration is decreased in rat kidney following fetal exposure to a maternallow-proteindiet. Journal of nutrition and metabolism. 2012, 989037
RYAN KJP, ELMES MJ and LANGLEY-EVANS SC, 2012. The effects of prenatal protein restriction on β-adrenergic signalling of the adult rat heart during ischaemia reperfusion. Journal of nutrition and metabolism. 2012, 397389
LLOYD LJ, LANGLEY-EVANS SC and MCMULLEN S, 2012. Childhood obesity and risk of the adult metabolic syndrome: a systematic review. International journal of obesity (2005). 36(1), 1-11
WRIGHT, T., LANGLEY-EVANS, S.C. and VOIGT, J.-P., 2011. The impact of maternal cafeteria diet on anxiety-related behaviour and exploration in the offspring. Physiology & Behavior. 103(2), 164-172
SWALI, A., MCMULLEN, S., HAYES, H., GAMBLING, L., MCARDLE, H.J. and LANGLEY-EVANS, SIMON C, 2011. Cell cycle regulation and cytoskeletal remodelling are critical processes in the nutritional programming of embryonic development. PLoS ONE. 6(8), e23189
WRIGHT, T.M., FONE, K.C.F., LANGLEY-EVANS, S.C. and VOIGT, J.P.W., 2011. Exposure to maternal consumption of cafeteria diet during the lactation period programmes feeding behaviour in the rat International Journal of Developmental Neuroscience. 29(8), 785-793
MCMULLEN S, LANGLEY-EVANS SC, GAMBLING L, LANG C, SWALI A and MCARDLE HJ, 2011. A Common Cause For A Common Phenotype: The Gatekeeper Hypothesis In Fetal Programming. Medical Hypotheses. (In Press.)
ANGELINA SWALI, SARAH MCMULLEN and SIMON LANGLEY-EVANS, 2010. Prenatal protein restriction leads to a disparity between aortic and peripheral blood pressure in Wistar male offspring. The Journal of physiology. 588(Pt 19), 3809-18
CORNOCK, R., LANGLEY-EVANS, S.C., MOBASHERI, A. and MCMULLEN, S., 2010. The impact of maternal protein restriction during rat pregnancy upon renal expression of angiotensin receptors and vasopressin-related aquaporins Reproductive Biology and Endocrinology. 8, 105
SIMON C LANGLEY-EVANS and SARAH MCMULLEN, 2010. Developmental origins of adult disease. Medical Principles and Practice. 19(2), 87-98
LLOYD, L.J., LANGLEY-EVANS S.C. and MCMULLEN, S., 2010. Childhood obesity and adult cardiovascular disease risk: a systematic review International Journal of Obesity. 34(1), 18-28
LANGLEY-EVANS, S.C., DANIEL, Z.C., WELLS, C.A., RYAN, K.J.P., PLANT, R. and WELHAM, S.J.M., 2010. Protein restriction in the pregnant mouse modifies fetal growth and pulmonary development: role of fetal exposure to β-hydroxybutyrate Experimental Physiology. 96(2), 203-215
BOGDARINA, I., HAASE, A., LANGLEY-EVANS, S. and CLARK, A.J.L., 2010. Glucocorticoid effects on the programming of AT1b Angiotensin receptor gene methylation and expression in the rat PLoS ONE. 5(2), e9237
YATES, Z., TARLING, E.J., LANGLEY-EVANS, S.C. and SALTER, A.M., 2009. Maternal undernutrition programmes atherosclerosis in the ApoE*3 Leiden mouse. British Journal of Nutrition. 101(8), 1185-1194
ELMES, M.J., HAASE, A., GARDNER, D.S. and LANGLEY-EVANS, SC., 2009. Sex differences in sensitivity to β-adrenergic agonist isoproterenol in the isolated adult rat heart following prenatal protein restriction British Journal of Nutrition. 101(5), 725-734
HARRISON, M. and LANGLEY-EVANS, SIMON C, 2009. Intergenerational programming of impaired nephrogenesis and hypertension in rats following maternal protein restriction during pregnancy British Journal of Nutrition. 101(7), 1020-1030
ENGEHAM, SARAH F, HAASE, ANDREA and LANGLEY-EVANS, SIMON C, 2009. Supplementation of a maternal low-protein diet in rat pregnancy with folic acid ameliorates programming effects upon feeding behaviour in the absence of disturbances to the methionine-homocysteine cycle. British Journal of Nutrition. 1-12
LANGLEY-EVANS, SIMON C, 2009. Nutritional programming of disease: unravelling the mechanism. Journal of Anatomy. 215(1), 36-51
AKYOL, ASLI, LANGLEY-EVANS, SIMON C and MCMULLEN, SARAH, 2009. Obesity induced by cafeteria feeding and pregnancy outcome in the rat. The British Journal of Nutrition. 102(11), 1601-10
WHITEHEAD, K., LANGLEY-EVANS, S.C., TISCHLER, V. and SWIFT, J.A., 2009. Communication skills for behaviour change in dietetic consultations Journal of Human Nutrition and Dietetics. 22(6), 493-500
ERHUMA, A, MCMULLEN, S, LANGLEY-EVANS, SC and BENNETT, AJ, 2009. Feeding Pregnant Rats A Low-Protein Diet Alters The Hepatic Expression Of Srebp-1C In Their Offspring Via A Glucocorticoid-Related Mechanism Endocrine. 36(2), 333-338
LANGLEY-EVANS, SC, 2009. Nutrition: A Lifespan Approach Chichester.
ELMES, M.J., MCMULLEN, S., GARDNER, D.S. and LANGLEY-EVANS, S.C., 2008. Prenatal diet determines susceptibility to cardiac ischaemia-reperfusion injury following treatment with diethylmaleic acid and N-acetylcysteine Life Sciences. 82(3-4), 149-155
MALLINSON, J.E., SCULLEY, D.V., CRAIGON, J., PLANT, R., LANGLEY-EVANS, S.C. and BRAMELD, J.M., 2007. Fetal exposure to a maternal low-protein diet during mid-gestation results in muscle-specific effects on fibre type composition in young rats British Journal of Nutrition. 98(2), 292-299
ERHUMA, A., SALTER, A.M., SCULLEY, D.V., LANGLEY-EVANS, S.C. and BENNETT, A.J., 2007. Prenatal exposure to a low-protein diet programs disordered regulation of lipid metabolism in the aging rat. American Journal of Physiology: Endocrinology and Metabolism. 292(6), E1702-E1714
ERHUMA, A., BELLINGER, L., LANGLEY-EVANS, S.C. and BENNETT, A.J, 2007. Prenatal exposure to undernutrition and programming of responses to high-fat feeding in the rat. British Journal of Nutrition. 2007, 1-8
RUTLAND, C.S., LATUNDE-DADA, A.O., THORPE, A., PLANT, R., LANGLEY-EVANS, S. and LEACH, L., 2007. Effect of gestational nutrition on vascular integrity in the murine placenta Placenta. 28(7), 734-742
ELMES, MATTHEW J, GARDNER, DAVID S and LANGLEY-EVANS, SIMON C, 2007. Fetal exposure to a maternal low-protein diet is associated with altered left ventricular pressure response to ischaemia-reperfusion injury. British Journal of Nutrition. 98(1), 93-100
LANGLEY-EVANS, S C, 2007. Metabolic programming in pregnancy: studies in animal models. Genes and Nutrition. 2(1), 33-8
LANGLEY-EVANS, S.C. and SCULLEY, D.V., 2006. The association between birthweight and longevity in the rat is complex and modulated by maternal protein intake during fetal life. FEBS Letters. 580(17), 4150-3
BELLINGER, L, SCULLEY, D V and LANGLEY-EVANS, S C, 2006. Exposure to undernutrition in fetal life determines fat distribution, locomotor activity and food intake in ageing rats. International Journal of Obesity. 30(5), 729-38
SIMON C LANGLEY-EVANS, CHRISTINA LILLEY AND SARAH MCMULLEN, 2006. Maternal protein restriction and fetal growth: lack of evidence of a role for homocysteine in fetal programming. British Journal of Nutrition. 96(3), 578-86
LANGLEY-EVANS, SIMON C, 2006. Developmental programming of health and disease. Proceedings of the Nutrition Society. 65(1), 97-105
CARRINGTON, LYNDA J and LANGLEY-EVANS, SIMON C, 2006. Wheezing and eczema in relation to infant anthropometry: evidence of developmental programming of disease in childhood. Maternal and Child Nutrition. 2(1), 51-61
LANGLEY-EVANS, S C and CARRINGTON, L J, 2006. Diet and the developing immune system. Lupus. 15(11), 746-52
GOPALAKRISHNAN, G.S., GARDNER, D.S., DANDREA, J., LANGLEY-EVANS, S.C., PEARCE, S., KURLAK, L.O., WALKER, R.M., SEETHO, I.W., KEISLER, D.H., RAMSAY, M.M., STEPHENSON, T. and SYMONDS, M.E., 2005. Influence of maternal pre-pregnancy body composition and diet during early-mid pregnancy on cardiovascular function and nephron number in juvenile sheep British Journal of Nutrition. 94(6), 938-947
MCMULLEN, S. and LANGLEY-EVANS, S.C., 2005. Sex-specific effects of prenatal low-protein and carbenoxolone exposure on renal angiotensin receptor expression in rats. Hypertension. 46(6), 1374-1380
MCMULLEN, S. and LANGLEY-EVANS, S.C., 2005. Maternal low-protein diet in rat pregnancy programs blood pressure through sex-specific mechanisms American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 288(1), R85-R90
LANGLEY-EVANS, S. C. and SCULLEY, D. V., 2005. Programming of hepatic antioxidant capacity and oxidative injury in the ageing rat Mechanisms of Ageing and Development. VOL 126(NUMBER 6-7), 804-812
MCMULLEN, SARAH and LANGLEY-EVANS, SIMON C, 2005. Essential hypertension: defending the contribution of a congenital nephron deficit. Hypertension. 46(2), e4; author reply e4-5
SIMON C LANGLEY-EVANS, LEANNE BELLINGER AND SARAH MCMULLEN, 2005. Animal models of programming: early life influences on appetite and feeding behaviour. Maternal and Child Nutrition. 1(3), 142-8
SIMON C LANGLEY-EVANS AND SARAH MCMULLEN, 2005. Fetal undernutrition and the programming of blood pressure Current Nutrition & Food Science. 1(2), 105-127
BELLINGER, LEANNE and LANGLEY-EVANS, SIMON C, 2005. Fetal programming of appetite by exposure to a maternal low-protein diet in the rat. Clinical Science. 109(4), 413-20
LANGLEY-EVANS SC, BELLINGER L, SCULLEY DV, LANGLEY-EVANS AJ, MCMULLEN S, 2005. In: WINTOUR-COGHLAN M, OWENS J, ed., Early Life Origins of Adult Health and Disease 573. Landes. 87-102
MCMULLEN, S., GARDNER, D.S. and LANGLEY-EVANS, S.C., 2004. Prenatal programming of angiotensin II type 2 receptor expression in the rat British Journal of Nutrition. 91(1), 133-140
BELLINGER, L., LILLEY, C. and LANGLEY-EVANS, S.C., 2004. Prenatal exposure to a maternal low-protein diet programmes a preference for high-fat foods in the young adult rat. British Journal of Nutrition. 92(3), 513-520
LANGLEY-EVANS SC, 2004. In: LANGLEY-EVANS SC, ed., Fetal nutrition and adult disease: Programming of chronic disease through fetal exposure to undernutrition CABI, Wallingford, UK. 157-170
LANGLEY-EVANS SC, ed., 2004. Programming of chronic disease through fetal exposure to undernutrition. CABI, Wallingford, UK.
LANGLEY-EVANS SC, 2004. In: LANGLEY-EVANS SC, ed., : Fetal nutrition and adult disease: Programming of chronic disease through fetal exposure to undernutrition CABI Wallingford. 1-20
LANGLEY-EVANS SC, 2004. In: LANGLEY-EVANS SC, ed., Fetal nutrition and adult disease: Programming of chronic disease through fetal exposure to undernutrition 129-156
LANGLEY-EVANS SC, 2004. In: NEILL S, KNOWLES H, ed., Biology of Child Health/ Aspects of Biological Development in Childhood Macmillan Palgrave, Basingstoke. 1-21
BRAMELD JM, FAHEY AJ, LANGLEY-EVANS SC, BUTTERY PJ, 2003. Nutritional and hormonal control of muscle growth and fat deposition Archives of Animal Breeding. 46, 143-156
SCULLEY, D. V. and LANGLEY-EVANS, S. C., 2003. Periodontal disease is associated with lower antioxidant capacity in whole saliva and evidence of increased protein oxidation Clinical Science. VOL 105(PART 2), 167-172
LANGLEY-EVANS, S C, LANGLEY-EVANS, A J and MARCHAND, M C, 2003. Nutritional programming of blood pressure and renal morphology. Archives of Physiology and Biochemistry. 111(1), 8-16
ROACH, HELMTRUD I, CLARKE, NICHOLAS M P, LANGLEY-EVANS, SIMON and COOPER, CYRUS, 2003. Catabolic and anabolic phases of osteodystrophy in aged rats. Journal of Bone and Mineral Metabolism. 21(5), 299-306
LANGLEY-EVANS, SIMON and LANGLEY-EVANS, ALISON, 2003. Energy intake in pregnant women carrying boys or girls: difference is chance observation. BMJ. 327(7415), 622
JACKSON, A.A., DUNN, R.L., MARCHAND, M.C. and LANGLEY-EVANS, S.C., 2002. Increased systolic blood pressure in rats induced by maternal low-protein diet is reversed by dietary supplementation with glycine Clinical Science. 103(6), 633-639
LANGLEY-EVANS, SIMON, 2002. Adult obesity and growth in childhood. Factors that programme resistance to obesity must be identified. BMJ. 324(7338), 674
SCULLEY, DEAN V and LANGLEY-EVANS, SIMON C, 2002. Salivary antioxidants and periodontal disease status. Proceedings of the Nutrition Society. 61(1), 137-43
LANGLEY-EVANS, SIMON C and LANGLEY-EVANS, ALISON J, 2002. Use of folic acid supplements in the first trimester of pregnancy. Journal of the Royal Society for the Promotion of Health. 122(3), 181-6
MEHTA, G, ROACH, H I, LANGLEY-EVANS, S, TAYLOR, P, READING, I, OREFFO, R O C, AIHIE-SAYER, A, CLARKE, N M P and COOPER, C, 2002. Intrauterine exposure to a maternal low protein diet reduces adult bone mass and alters growth plate morphology in rats. Calcified Tissue International. 71(6), 493-8
SAYER, A.A., DUNN, R.L., LANGLEY-EVANS, S.C. and COOPER, S., 2001. Intrauterine exposure to a maternal low protein diet shortens lifespan in rats. Gerontology. 47, 9-14
LANGLEY-EVANS, S C, 2001. Fetal programming of cardiovascular function through exposure to maternal undernutrition. Proceedings of the Nutrition Society. 60(4), 505-13
LANGLEY-EVANS, S, 2001. Fetal growth markers may show nutritionally mediated effect. British Medical Journal. 323(7303), 52
LANGLEY-EVANS, S.C., 2001. Tea as a protective agent in cardiovascular health Nutrition and Food Science. 31, 75
FURNEAUX, E C, LANGLEY-EVANS, A J and LANGLEY-EVANS, S C, 2001. Nausea and vomiting of pregnancy: endocrine basis and contribution to pregnancy outcome. Obstetric and Gynecological Survey. 56(12), 775-82
MARCHAND MC, LANGLEY-EVANS SC, 2001. Intrauterine programming of nephron number: the fetal flaw revisited Journal of Nephrology. 14, 327-331
LANGLEY-EVANS, S C, 2000. Critical differences between two low protein diet protocols in the programming of hypertension in the rat. International Journal of Food Sciences and Nutrition. 51(1), 11-7
LANGLEY-EVANS, S C, 2000. Antioxidant potential of green and black tea determined using the ferric reducing power (FRAP) assay. International Journal of Food Sciences and Nutrition. 51(3), 181-8
LANGLEY-EVANS, S C, 2000. Consumption of black tea elicits an increase in plasma antioxidant potential in humans. International Journal of Food Sciences and Nutrition. 51(5), 309-15
SHERMAN, R C and LANGLEY-EVANS, S C, 2000. Antihypertensive treatment in early postnatal life modulates prenatal dietary influences upon blood pressure in the rat. Clinical Science. 98(3), 269-75
NWAGWU, M O, COOK, A and LANGLEY-EVANS, S C, 2000. Evidence of progressive deterioration of renal function in rats exposed to a maternal low-protein diet in utero. British Journal of Nutrition. 83(1), 79-85
LANGLEY-EVANS, S. C., SHERMAN, R. C., WELHAM, S. J. M., NWAGWU, M. O., GARDNER, D. S. and JACKSON, A. A., 1999. Intrauterine programming of hypertension: the role of the renin-angiotensin system Biochemical Society Transactions. VOL 27(NUMBER 2), 88-93
LANGLEY-EVANS, S C, WELHAM, S J and JACKSON, A A, 1999. Fetal exposure to a maternal low protein diet impairs nephrogenesis and promotes hypertension in the rat. Life Sciences. 64(11), 965-74
LANGLEY-EVANS SC, 1999. In: MCCARTY R, BLIZZARD DA, CHEVALIER RL, ed., Development of the Hypertensive Phenotype: Basic and Clinical Studies 19. Elsevier Sciences, New York. 539-574
LANGLEY-EVANS SC, 1999. In: O'BRIEN PMS, WHEELER T, BARKER DJP, ed., Fetal Programming: Influences on Development of Disease in Later Life RCOG Press, London. 374-388
LANGLEY-EVANS, S C, 1999. Fetal origins of adult disease. British Journal of Nutrition. 81(1), 5-6
SHERMAN, R C, JACKSON, A A and LANGLEY-EVANS, S C, 1999. Long-term modification of the excretion of prostaglandin E(2) by fetal exposure to a maternal low protein diet in the rat. Annals of Nutrition and Metabolism. 43(2), 98-106
LANGLEY-EVANS, S C, GARDNER, D S and WELHAM, S J, 1998. Intrauterine programming of cardiovascular disease by maternal nutritional status. Nutrition. 14(1), 39-47
GARDNER, D. S., JACKSON, A. A. and LANGLEY-EVANS, S. C., 1998. The effect of prenatal diet and glucocorticoids on growth and systolic blood pressure in the rat Proceedings of the Nutrition Society. VOL 57(NUMBER 2), 235-240
SHERMAN, R C and LANGLEY-EVANS, S C, 1998. Early administration of angiotensin-converting enzyme inhibitor captopril, prevents the development of hypertension programmed by intrauterine exposure to a maternal low-protein diet in the rat. Clinical Science. 94(4), 373-81
LANGLEY-EVANS, S C and NWAGWU, M, 1998. Impaired growth and increased glucocorticoid-sensitive enzyme activities in tissues of rat fetuses exposed to maternal low protein diets. Life Sciences. 63(7), 605-15
GARDNER, D S, JACKSON, A A and LANGLEY-EVANS, S C, 1997. Maintenance of maternal diet-induced hypertension in the rat is dependent on glucocorticoids. Hypertension. 30(6), 1525-30
LANGLEY-EVANS, S C, 1997. Maternal carbenoxolone treatment lowers birthweight and induces hypertension in the offspring of rats fed a protein-replete diet. Clinical Science. 93(5), 423-9
LANGLEY-EVANS, S C, 1997. Intrauterine programming of hypertension by glucocorticoids. Life Sciences. 60(15), 1213-21
LANGLEY-EVANS, S C, 1997. Hypertension induced by foetal exposure to a maternal low-protein diet, in the rat, is prevented by pharmacological blockade of maternal glucocorticoid synthesis. Journal of Hypertension. 15(5), 537-44
LANGLEY-EVANS, S, 1997. Fetal programming of immune function and respiratory disease. Clinical and Experimental Allergy. 27(12), 1377-9
LANGLEY-EVANS, S C, PHILLIPS, G J and JACKSON, A A, 1997. Fetal exposure to low protein maternal diet alters the susceptibility of young adult rats to sulfur dioxide-induced lung injury. Journal of Nutrition. 127(2), 202-9
LANGLEY-EVANS SC, PHILLIPS GJ, GARDNER DS, JACKSON AA, 1996. Role of glucocorticoids in programming of maternal-diet-induced hypertension Journal of Nutritional Biochemistry. 7, 173-178
LANGLEY-EVANS, S C, GARDNER, D S and JACKSON, A A, 1996. Association of disproportionate growth of fetal rats in late gestation with raised systolic blood pressure in later life. Journal of Reproduction and Fertility. 106(2), 307-12
LANGLEY-EVANS, S C, WELHAM, S J, SHERMAN, R C and JACKSON, A A, 1996. Weanling rats exposed to maternal low-protein diets during discrete periods of gestation exhibit differing severity of hypertension. Clinical Science. 91(5), 607-15
LANGLEY-EVANS, S C, GARDNER, D S and JACKSON, A A, 1996. Maternal protein restriction influences the programming of the rat hypothalamic-pituitary-adrenal axis. Journal of Nutrition. 126(6), 1578-85
LANGLEY-EVANS, S. C., PHILLIPS, G. J., BENEDIKTSSON, R., GARDNER, D. S., EDWARDS, C. R. W., JACKSON, A. A. and SECKL, J. R., 1996. Protein Intake in Pregnancy, Placental Glucocorticoid Metabolism and the Programming of Hypertension in the Rat Placenta. VOL 17(NUMBER 2/3), 169-172
JACKSON, A A, LANGLEY-EVANS, S C and MCCARTHY, H D, 1996. Nutritional influences in early life upon obesity and body proportions. Ciba Foundation Symposium. 201, 118-29; discussion 129-37, 188-93
LANGLEY-EVANS, S C, PHILLIPS, G J and JACKSON, A A, 1996. Sulphur dioxide: a potent glutathione depleting agent. Comparative Biochemistry and Physiology. Part C: Toxicology and Pharmacology. 114(2), 89-98
LANGLEY-EVANS, S and JACKSON, A, 1996. Intrauterine programming of hypertension: nutrient-hormone interactions. Nutrition reviews.. 54(6), 163-9
LANGLEY-EVANS, S C, 1996. Intrauterine programming of hypertension in the rat: nutrient interactions. Comparative Biochemistry and Physiology. Part A: Physiology. 114(4), 327-33
LANGLEY-EVANS, S C and JACKSON, A A, 1996. Rats with hypertension induced by in utero exposure to maternal low-protein diets fail to increase blood pressure in response to a high salt intake. Annals of Nutrition and Metabolism. 40(1), 1-9
LANGLEY-EVANS, S C, CLAMP, A G, GRIMBLE, R F and JACKSON, A A, 1996. Influence of dietary fats upon systolic blood pressure in the rat. International Journal of Food Sciences and Nutrition. 47(5), 417-25
LANGLEY-EVANS, S C, WOOD, S and JACKSON, A A, 1995. Enzymes of the gamma-glutamyl cycle are programmed in utero by maternal nutrition. Annals of Nutrition and Metabolism. 39(1), 28-35
LANGLEY-EVANS, S C and JACKSON, A A, 1995. Captopril normalises systolic blood pressure in rats with hypertension induced by fetal exposure to maternal low protein diets. Comparative Biochemistry and Physiology. Part A: Physiology. 110(3), 223-8
TAPPIA, P S, TROUGHTON, K L, LANGLEY-EVANS, S C and GRIMBLE, R F, 1995. Cigarette smoking influences cytokine production and antioxidant defences. Clinical Science. 88(4), 485-9
LANGLEY, S C and KELLY, F J, 1994. Depletion of pulmonary glutathione using diethylmaleic acid accelerates the development of oxygen-induced lung injury in term and preterm guinea-pig neonates. Journal of Pharmacy and Pharmacology. 46(2), 98-102
LANGLEY, S C, BROWNE, R F and JACKSON, A A, 1994. Altered glucose tolerance in rats exposed to maternal low protein diets in utero. Comparative biochemistry and physiology. Physiology.. 109(2), 223-9
LANGLEY, S C, SEAKINS, M, GRIMBLE, R F and JACKSON, A A, 1994. The acute phase response of adult rats is altered by in utero exposure to maternal low protein diets. Journal of Nutrition. 124(9), 1588-96
LANGLEY-EVANS, S C, PHILLIPS, G J and JACKSON, A A, 1994. In utero exposure to maternal low protein diets induces hypertension in weanling rats, independently of maternal blood pressure changes. Clinical Nutrition. 13(5), 319-24
LANGLEY, S C and JACKSON, A A, 1994. Increased systolic blood pressure in adult rats induced by fetal exposure to maternal low protein diets. Clinical Science. 86(2), 217-22; discussion 121
LANGLEY, S C and KELLY, F J, 1993. N-acetylcysteine ameliorates hyperoxic lung injury in the preterm guinea pig. Biochemical Pharmacology. 45(4), 841-6
LANGLEY, S C, RICKETT, G W, HUNT, A, KELLY, F J, POSTLE, A D and YORK, D A, 1993. Effects of the glucocorticoid agonist, RU28362, and the antagonist RU486 on lung phosphatidylcholine and antioxidant enzyme development in the genetically obese Zucker rat. Biochemical Pharmacology. 45(3), 543-51
LANGLEY SC, BROWN RK, KELLY FJ, 1993. In: CORONGUI F, DESSI MA, RICE-EVANS C, ed., Antioxidants and Nutrition Richelieu Press. 135-152
LANGLEY, S C, BROWN, R K and KELLY, F J, 1993. Reduced free-radical-trapping capacity and altered plasma antioxidant status in cystic fibrosis. Pediatric Research. 33(3), 247-50
LANGLEY, S C and KELLY, F J, 1992. Differing response of the glutathione system to fasting in neonatal and adult guinea pigs. Biochemical Pharmacology. 44(8), 1489-94
LANGLEY, S C, PHILLIPS, G J, TAHEDL, S and KELLY, F J, 1992. Dietary supplementation of vitamin E fails to prevent the development of hyperoxic lung injury in the premature guinea pig. Comparative biochemistry and physiology. Comparative physiology.. 103(4), 793-9
LANGLEY, S C and KELLY, F J, 1992. Effect of food restriction on hyperoxia-induced lung injury in preterm guinea pig. American Journal of Physiology. 263(3 Pt 1), L357-62
YORK DA, LANGLEY SC, 1992. In: BRAY GA, RYAN D, ed., The Science of Food Regulation Louisiana University Press. 132-149
LANGLEY, S C and YORK, D A, 1992. Glucocorticoid receptor numbers in the brain and liver of the obese Zucker rat. International Journal of Obesity. 16(2), 135-43
LANGLEY, S C and YORK, D A, 1990. Increased type II glucocorticoid-receptor numbers and glucocorticoid-sensitive enzyme activities in the brain of the obese Zucker rat. Brain Research. 533(2), 268-74
LANGLEY, S C and YORK, D A, 1990. Effects of antiglucocorticoid RU 486 on development of obesity in obese fa/fa Zucker rats. American Journal of Physiology. 259(3 Pt 2), R539-44
YORK DA, LANGLEY S, STUBBS M, 1990. In: OOMURA Y, ed., Progress in Obesity Research John Libbey, London. 88-94
JONES, S M, BROOKS, B A, LANGLEY, S C, IDLE, J R and HIROM, P C, 1988. Glutathione transferase activities of cultured human lymphocytes. Carcinogenesis. 9(3), 395-8
TARLING EJ, RYAN KJ, KUGLER SJ, SALTER AM and LANGLEY-EVANS SC, Maternal high-fat feeding in pregnancy programs atherosclerotic lesion size in the ApoE*3 Leiden mouse. J Dev Orig Health Dis.. (In Press.)