William Dunn

Contact

• workRoom E34a University of Nottingham Medical School
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 82 30188
• fax0115 82 30142
• william.dunn@nottingham.ac.uk

Teaching Summary

Director, BMedSci

Research Summary

Interests

• The structure and function of human blood vessels in health and disease.
• Endothelial function in normal pregnancy and in pregnancies complicated by pre-eclampsia.
• Autonomic neurotransmission in small arteries.
• Impact of perivascular fat on vascular function

Techniques

• Pressure myography.
• Sharp microelectrode recordings of membrane potential.
• Continuous amperometry for real-time monitoring of noradrenaline release from sympathetic nerves.
• Light and electron microscopy.

Selected Publications

• HAMMOND, S., MATHEWSON, A.M., BAKER, P.N., MAYHEW, T.M. and DUNN, W.R., 2011. Gap junctions and hydrogen peroxide are involved in endothelium-derived hyperpolarising responses to bradykinin in omental arteries and veins isolated from pregnant women European Journal of Pharmacology. 668(1-2), 225-232
• HOPPS, J.J., DUNN, W.R. and RANDALL, M.D., 2012. Enhanced vasorelaxant effects of the endocannabinoid-like mediator, oleamide, in hypertension. European Journal of Pharmacology. 684, 102-107
• HOPPS, J.J., DUNN, W.R. and RANDALL, M.D., 2012. Vasorelaxation to capsaicin and its effects on calcium influx in arteries. European Journal of Pharmacology. 681, 88-93
• MOORE, R.J., ONG, S.S., TYLER, D.J., DUCKETT, R., BAKER, P.N., DUNN, W.R., JOHNSON, I.R. and GOWLAND, P.A., 2008. Spiral artery blood volume in normal pregnancies and those compromised by pre-eclampsia NMR in Biomedicine. 21(4), 376-380

• View all publications

Future Research

Cardiovascular science, pre-eclampsia, hypertension, sympathetic neurotransmission.

• ABBAS, ZAINAB S. B., LATIF, M. LIAQUE, DOVLATOVA, NATALIA, FOX, SUE C., HEPTINSTALL, STAN, DUNN, WILLIAM R. and RALEVIC, VERA, 2018. UDP-sugars activate P2Y(14) receptors to mediate vasoconstriction of the porcine coronary artery VASCULAR PHARMACOLOGY. 103, 36-46
• DONOVAN J, WONG PS, GARLE MJ, ALEXANDER SPH, DUNN WR and RALEVIC V, 2018. Coronary artery hypoxic vasorelaxation is augmented by perivascular adipose tissue through a mechanism involving hydrogen sulphide and cystathionine-β-synthase. Acta physiologica (Oxford, England). 224(4), e13126
• ABU BAKAR H, DUNN WR, DALY C and RALEVIC V, 2017. Sensory innervation of perivascular adipose tissue: a crucial role in artery vasodilatation and leptin release. Cardiovascular research. 113(8), 962-972
• DONOVAN J, WONG PS, ROBERTS RE, GARLE MJ, ALEXANDER SPH, DUNN WR and RALEVIC V, 2017. A critical role for cystathionine-β-synthase in hydrogen sulfide-mediated hypoxic relaxation of the coronary artery. Vascular pharmacology. 93-95, 20-32
• RALEVIC V and DUNN WR, 2015. Purinergic transmission in blood vessels. Autonomic neuroscience : basic & clinical. 191, 48-66
• DUNN WR, ALEXANDER SP, RALEVIC V and ROBERTS RE, 2015. Effects of hydrogen sulphide in smooth muscle. Pharmacology & therapeutics. 158, 101-13
• MOKORI, E., RALEVIC, V. and DUNN, W., 2015. PANNEXIN CHANNELS -THE PATHWAY TO SMOOTH MUSCLE COMMUNICATION IN RESISTANCE ARTERIES. JOURNAL OF VASCULAR RESEARCH. 52, 44-44
• DONOVAN, JEMMA, GARLE, MICHAEL J., ALEXANDER, STEPHEN P. H., DUNN, WILLIAM R. and RALEVIC, VERA, 2015. Perivascular adipose tissue derived hydrogen sulphide contributes to hypoxic relaxation of the porcine coronary artery Nitric Oxide-Biology and Chemistry. 47, S27-S27
• MATHEWSON AM and DUNN WR, 2014. A comparison of responses to raised extracellular potassium and endothelium-derived hyperpolarizing factor (EDHF) in rat pressurised mesenteric arteries. PloS one. 9(11), e111977
• SHATARAT A, DUNN WR and RALEVIC V, 2014. Raised tone reveals ATP as a sympathetic neurotransmitter in the porcine mesenteric arterial bed. Purinergic signalling. 10(4), 639-49
• WHITE, B.J.O., SMITH, P.A. and DUNN, W.R., 2013. Hydrogen sulphide-mediated vasodilatation involves the release of neurotransmitters from sensory nerves in pressurized mesenteric small arteries isolated from rats British Journal of Pharmacology. 168(4), 785-793
• GOONETILLEKE, L., RALEVIC, V. and DUNN, W.R., 2013. Influence of pressure on adenosine triphosphate function as a sympathetic neurotransmitter in small mesenteric arteries from the spontaneously hypertensive rat Journal of Hypertension. 31(2), 312-320
• HOPPS, J.J., DUNN, W.R. and RANDALL, M.D., 2012. Vasorelaxation to capsaicin and its effects on calcium influx in arteries. European Journal of Pharmacology. 681, 88-93
• HOPPS, J.J., DUNN, W.R. and RANDALL, M.D., 2012. Enhanced vasorelaxant effects of the endocannabinoid-like mediator, oleamide, in hypertension. European Journal of Pharmacology. 684, 102-107
• HAMMOND, S., MATHEWSON, A.M., BAKER, P.N., MAYHEW, T.M. and DUNN, W.R., 2011. Gap junctions and hydrogen peroxide are involved in endothelium-derived hyperpolarising responses to bradykinin in omental arteries and veins isolated from pregnant women European Journal of Pharmacology. 668(1-2), 225-232
• MOORE, R.J., ONG, S.S., TYLER, D.J., DUCKETT, R., BAKER, P.N., DUNN, W.R., JOHNSON, I.R. and GOWLAND, P.A., 2008. Spiral artery blood volume in normal pregnancies and those compromised by pre-eclampsia NMR in Biomedicine. 21(4), 376-380
• RUMMERY, N.M, BROCK, J.A, PAKDEECHOTE, P., RALEVIC, V. and DUNN, W.R, 2007. ATP is the predominant sympathetic neurotransmitter in rat mesenteric arteries at high pressure. Journal of Physiology. 582(2), 745-754
• PAKDEECHOTE, POUNGRAT, RUMMERY, NICOLE M, RALEVIC, VERA and DUNN, WILLIAM R, 2007. Raised tone reveals purinergic-mediated responses to sympathetic nerve stimulation in the rat perfused mesenteric vascular bed. European Journal of Pharmacology. 563(1-3), 180-6
• PAKDEECHOTE, P, DUNN, W R and RALEVIC, V, 2007. Cannabinoids inhibit noradrenergic and purinergic sympathetic cotransmission in the rat isolated mesenteric arterial bed. British Journal of Pharmacology. 152(5), 725-33
• ONG, S.S., BAKER, P.N., MAYHEW, T.M. and DUNN, W.R, 2005. Remodeling of myometrial radial arteries in preeclampsia. American Journal of Obstetrics and Gynecology. 192(2), 572-579
• WOOLARD, J., BENNETT, T., DUNN, W. R., HEAL, D. J., ASPLEY, S. and GARDINER, S. M., 2004. Acute cardiovascular effects of sibutramine in conscious rats Journal of Pharmacology and Experimental Therapeutics. 308(3), 1102-1110
• DUNN, W.R., HARDY, T.A. and BROCK, J.A, 2003. Electrophysiological effects of activating the peptidergic primary afferent innervation of rat mesenteric arteries. British Journal of Pharmacology. 140(2), 231-238
• WANG, M., DUNN, W.R., CHAN, S.L., GARFIELD, B. and WILSON, V.G, 2003. Evidence for nonadrenoceptor responses to imidazoline derivatives in the porcine isolated rectal artery. Annals of the New York Academy of Sciences. 1009, 386-91
• KENNY, L.C., BAKER, P.N., KENDALL, D.A., RANDALL, M.D. and DUNN, W.R, 2002. Differential mechanisms of endothelium-dependent vasodilator responses in human myometrial small arteries in normal pregnancy and pre-eclampsia. Clinical Science. 103(1), 67-73
• KENNY, L.C., BAKER, P.N., KENDALL, D.A., RANDALL, M.D. and DUNN, W.R, 2002. The role of gap junctions in mediating endothelium-dependent responses to bradykinin in myometrial small arteries isolated from pregnant women British Journal of Pharmacology. 136(8), 1085-1088
• ONG, S.S., BAKER, P.N., MAYHEW, T.M. and DUNN, W.R, 2002. No difference in structure between omental small arteries isolated from women with preeclampsia, intrauterine growth restriction, and normal pregnancies American Journal of Obstetrics and Gynecology. 187(3), 606-610
• MINYAN, W, . DUNN, W. R., BLAYLOCK, N. A., CHAN, S. L.F. and WILSON, V.G, 2001. Evidence for a non-adrenoceptor, imidazoline-mediated contractile response to oxymetazoline in the porcine isolated rectal artery. British Journal of Pharmacology. 132(7), 1359-1363
• BROCK, J A, DUNN, W R, BOYD, N S and WONG, D K, 2000. Spontaneous release of large packets of noradrenaline from sympathetic nerve terminals in rat mesenteric arteries in vitro. British Journal of Pharmacology. 131(8), 1507-11
• LAWRENCE, R. N., DUNN, W. R., BYCROFT, B., CAMARA, M., CHHABRA, S. R., WILLIAMS, P. and WILSON, V. G., 1999. The Pseudomonas aeruginosa quorum-sensing signal molecule, N-(3-oxododecanoyl)-L-homoserine lactone, inhibits porcine arterial smooth muscle contraction British Journal of Pharmacology. VOL 128(NUMBER 4), 845-848
• DUNN, W R, BROCK, J A and HARDY, T A, 1999. Electrochemical and electrophysiological characterization of neurotransmitter release from sympathetic nerves supplying rat mesenteric arteries. British Journal of Pharmacology. 128(1), 174-80
• LAWRENCE, R N, CLELLAND, C, BEGGS, D, SALAMA, F D, DUNN, W R and WILSON, V G, 1998. Differential role of vasoactive prostanoids in porcine and human isolated pulmonary arteries in response to endothelium-dependent relaxants. British Journal of Pharmacology. 125(6), 1128-37
• LAWRENCE, R N, DUNN, W R and WILSON, V G, 1998. Endothelium-dependent relaxation in response to ethanol in the porcine isolated pulmonary artery. Journal of Pharmacy and Pharmacology. 50(8), 885-90
• TING, K N, DUNN, W R, DAVIES, D J, SUGDEN, D, DELAGRANGE, P, GUARDIOLA-LEMAîTRE, B, SCALBERT, E and WILSON, V G, 1997. Studies on the vasoconstrictor action of melatonin and putative melatonin receptor ligands in the tail artery of juvenile Wistar rats. British Journal of Pharmacology. 122(7), 1299-306
• WALLIS, S J, FIRTH, J and DUNN, W R, 1996. Pressure-induced myogenic responses in human isolated cerebral resistance arteries. Stroke. 27(12), 2287-90; discussion 2291
• MCGRATH, J C, DUNN, W R and TEMPLETON, A G, 1990. Physiological modulation of alpha-adrenoceptor and 5HT receptor expression in blood vessels. Blood vessels. 27(2-5), 146-52
• DUNN, W R, MCGRATH, J C and WILSON, V G, 1989. Expression of functional postjunctional alpha 2-adrenoceptors in rabbit isolated distal saphenous artery--a permissive role for angiotensin II? British Journal of Pharmacology. 96(2), 259-61
• DALY, C J, DUNN, W R, MCGRATH, J C and WILSON, V G, 1988. An attempt at selective protection from phenoxybenzamine of postjunctional alpha-adrenoceptor subtypes mediating contractions to noradrenaline in the rabbit isolated saphenous vein. British Journal of Pharmacology. 95(2), 501-11
• DUNN, W R, WALLIS, S J and GARDINER, S M, Remodelling and enhanced myogenic tone in cerebral resistance arteries isolated from genetically hypertensive Brattleboro rats. Journal of vascular research.. 35(1), 18-26