Biotechnology and Biological Sciences Doctoral Training Programme

Available projects


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Please note the list of projects available will be updated with additional projects, so please check frequently. Project details may also be subject to change before September 2018.

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View all our available projects

Investigating the differential regulation of cell surface GAG in breast cancer: Using NGPD to isolate cancer cell specific peptides

In this project, we propose to identify cell-type specific variants in breast cancer patient samples in a high-throughput manner using phage display-libraries (1010 phage) of GET peptides and next-generation sequencing (NGS) in a process called next generation phage display (NGPD).

Molecular approaches to understanding allosteric modulation at the M1 Muscarinic Acetylcholine Receptor (mAChR)

This chemical biology-focused project will span the disciplines of synthetic chemistry and pharmacology to increase our understanding of the M1 mAChR. With increasing numbers of allosteric ligands being discovered for the wider G protein-coupled receptor family, the results will be of direct relevance to many other important receptors.

A ligand-guided strategy for fluorescent labelling of native cellular receptors

We have an internationally recognized track record in the design, synthesis and application of fluorescently conjugated G-Protein Coupled Receptor (GPCR) ligands. The hypothesis behind this project takes this concept and extends it to the design of molecules capable of covalently transferring a fluorescent cargo to a region of a GPCR distal to the ligand-binding site.
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Biotechnology and Biological Sciences Doctoral Training Programme

The University of Nottingham
University Park
Nottingham, NG7 2RD

Tel: +44 (0) 115 8466946