Biotechnology and Biological Sciences Doctoral Training Programme

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Please note the list of projects available will be updated with additional projects, so please check frequently. Project details may also be subject to change before September 2018.

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The regulation of polyadenylation in inducible gene expression

In this project you will use genetic manipulation of cell lines, including siRNA transfection, CRISPR-Cas9 knockout and recombination of genes and overexpression of wild type and mutant proteins to characterise the pathways involved in the regulation of polyadenylation.

Extracellular communication via exosomes and their microRNAs: does the extracellular matrix play a role?

The aim of this project is to determine whether the ECM affects the exchange of miRNAs between cells. Collectively, this project is designed to gain fundamental understanding of the trafficking and delivery of microRNA-carrying exosomes, a cell-to-cell communication mechanism that is gaining growing attention

MicroRNA regulation on the inflammatory response

This project aims to understand miRNA regulation in the context of the inflammatory response, in which cells rapidly switch on the production of many mRNAs that encode inflammatory proteins.

Molecular and in-silico interrogation of novel modes of binding at G protein-coupled receptors (GPCRs)

We have recently identified, through advanced molecular modelling methods, a possible novel mode of binding of experimental subtype-selective ligands to beta adrenoceptors.The aim of this multidisciplinary project will be to design, synthesise and pharmacologically characterise a library of ligands to test this hypothesis more rigorously.

Understanding DNA repair in adult tissues: Precision cut lung slices (PCLS) as a model for repair mechanisms and testing of gene editing strategies

This PhD project will assess DNA repair and gene editing in native human lung tissue with the same tissue architecture and biological activity as that found in the body. The project will use patient-derived precision cut lung slices (PCLS) in vitro a model, and explore the DNA repair activity in the different stem cells, and post-mitotic cells.

Understanding the biological relevance of G protein coupled receptor glycosylation: a combined computational and experimental approach.

Our aim is to determine the mechanisms throughwhich the glycosylation of candidate GPCRs modulates ligand binding, signallingand receptor oligomerisation, integrating molecular models of the glycosylatedreceptors (CL), biochemical and pharmacological analysis (SB / NH), andinnovative imaging approaches to determine receptor oligomeric state (SB).
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Biotechnology and Biological Sciences Doctoral Training Programme

The University of Nottingham
University Park
Nottingham, NG7 2RD

Tel: +44 (0) 115 8466946