Biotechnology and Biological Sciences Doctoral Training Programme

Molecules, Cells and Organisms projects


Please note that the list of projects available will be increased over the next few weeks so please check frequently. Project details may also be subject to change before September 2018.


BBSRC Doctoral Training Partnerships




View all Molecules, Cells and Organisms projects

Generation and characterisation of nanoparticles with different size and shape

By applying advanced analytical tools we can gain improved understanding into the cellular response of macrophages and ultimately immune response. The project can also underpin the development of new tools for immune modulation in addition to enhanced understanding of biological mechanisms of macrophage behaviour.

Exploring the Function of Gene Regulators by CRISPR CAS9 Genome Editing

This project will utilise these cell lines in 'rescue' experiments by re-expression of wild type or mutant KAT6A to determine function. We will generate mutations in different functional domains in KAT6A to assess their requirement for regulation of a panel target genes by qPCR.

PIP5K1A – integrating lipid signalling with nuclear function

The project will integrate with structure function studies ongoing with groups in Sweden and Nottingham. For example our collaborators in Sweden have generated a small molecule inhibitor of PIP5K1A (Semenas 2014 PNAS; (Sarwar et al Oncotarget 2016; Karlsson et al.,submitted) which prevents the growth of metastatic prostate tumours in animal models. We hope to determine the structure of PIP5K1A in complex with its inhibitor with our collaborators in structural biology

The regulation of polyadenylation in inducible gene expression

In this project you will use genetic manipulation of cell lines, including siRNA transfection, CRISPR-Cas9 knockout and recombination of genes and overexpression of wild type and mutant proteins to characterise the pathways involved in the regulation of polyadenylation.
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Biotechnology and Biological Sciences Doctoral Training Programme

The University of Nottingham
University Park
Nottingham, NG7 2RD

Tel: +44 (0) 115 8466946