Biotechnology and Biological Sciences Doctoral Training Programme
   
   
  

Molecules, Cells and Organisms projects

 

Please note that the list of projects available will be increased over the next few weeks so please check frequently. Project details may also be subject to change before September 2018.

 

BBSRC Doctoral Training Partnerships

 

 

 

View all Molecules, Cells and Organisms projects

A ligand-guided strategy for fluorescent labelling of native cellular receptors

Description
We have an internationally recognized track record in the design, synthesis and application of fluorescently conjugated G-Protein Coupled Receptor (GPCR) ligands. The hypothesis behind this project takes this concept and extends it to the design of molecules capable of covalently transferring a fluorescent cargo to a region of a GPCR distal to the ligand-binding site.

Structure and function of molecular machines involved in eukaryotic RNA degradation and microRNA-mediated repression

Description
The training includes an opportunity to work at world-class facilities at the Research Complex at Harwell. The student will benefit from transferable skills associated with protein expression and purification, enzymology, as well as the characterisation of biochemical samples using biophysical techniques

PIP5K1A – integrating lipid signalling with nuclear function

Description
The project will integrate with structure function studies ongoing with groups in Sweden and Nottingham. For example our collaborators in Sweden have generated a small molecule inhibitor of PIP5K1A (Semenas 2014 PNAS; (Sarwar et al Oncotarget 2016; Karlsson et al.,submitted) which prevents the growth of metastatic prostate tumours in animal models. We hope to determine the structure of PIP5K1A in complex with its inhibitor with our collaborators in structural biology

Understanding the biological relevance of G protein coupled receptor glycosylation: a combined computational and experimental approach.

Description
Our aim is to determine the mechanisms throughwhich the glycosylation of candidate GPCRs modulates ligand binding, signallingand receptor oligomerisation, integrating molecular models of the glycosylatedreceptors (CL), biochemical and pharmacological analysis (SB / NH), andinnovative imaging approaches to determine receptor oligomeric state (SB).
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Biotechnology and Biological Sciences Doctoral Training Programme

The University of Nottingham
University Park
Nottingham, NG7 2RD

Tel: +44 (0) 115 8466946
Email: bbdtp@nottingham.ac.uk