Biotechnology and Biological Sciences Doctoral Training Programme
   
   
  

Molecules, Cells and Organisms projects

 

Please note that the list of projects available will be increased over the next few weeks so please check frequently. Project details may also be subject to change before September 2018.

 

BBSRC Doctoral Training Partnerships

 

 

 

View all Molecules, Cells and Organisms projects

Investigating the differential regulation of cell surface GAG in breast cancer: Using NGPD to isolate cancer cell specific peptides

Description
In this project, we propose to identify cell-type specific variants in breast cancer patient samples in a high-throughput manner using phage display-libraries (1010 phage) of GET peptides and next-generation sequencing (NGS) in a process called next generation phage display (NGPD).

PIP5K1A – integrating lipid signalling with nuclear function

Description
The project will integrate with structure function studies ongoing with groups in Sweden and Nottingham. For example our collaborators in Sweden have generated a small molecule inhibitor of PIP5K1A (Semenas 2014 PNAS; (Sarwar et al Oncotarget 2016; Karlsson et al.,submitted) which prevents the growth of metastatic prostate tumours in animal models. We hope to determine the structure of PIP5K1A in complex with its inhibitor with our collaborators in structural biology

Understanding the biological relevance of G protein coupled receptor glycosylation: a combined computational and experimental approach.

Description
Our aim is to determine the mechanisms throughwhich the glycosylation of candidate GPCRs modulates ligand binding, signallingand receptor oligomerisation, integrating molecular models of the glycosylatedreceptors (CL), biochemical and pharmacological analysis (SB / NH), andinnovative imaging approaches to determine receptor oligomeric state (SB).
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Biotechnology and Biological Sciences Doctoral Training Programme

The University of Nottingham
University Park
Nottingham, NG7 2RD

Tel: +44 (0) 115 8466946
Email: bbdtp@nottingham.ac.uk