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David Salt

Professor of Genome Enabled Biology, Faculty of Science

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Biography

EMPLOYMENT HISTORY

  • 1993 - 1997 Assistant Research Professor, Center for Agricultural Molecular Biology, Rutgers University, New Brunswick, NJ, USA
  • 1995 - 1999 Consultant and member of Science Advisory Board for Phytotech Inc, Monmouth Junction, NJ, USA
  • 1998 - 2000 Assistant Professor of Biochemistry, Department of Chemistry, Northern Arizona University, Flagstaff, AZ, USA.
  • 2000 - 2004 Consultant and member of Science Advisory Board for NuCycle Inc., Monmouth Junction, NJ.
  • 2000 - 2001 Associate Professor of Biochemistry, Dept of Chemistry, Northern Arizona University, Flagstaff, AZ, USA.
  • 2001 - 2005 Associate Professor of Plant Science, Dept Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN, USA.
  • 2004 - 2007 Scientific Director for Genomic Research and Technology, Bindley Bioscience Center, Discovery Park, Purdue University, West Lafayette, IN, USA.
  • 2005 - 2011 Professor of Plant Science, Dept Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN, USA
  • 2011 - present Adjunct Professor of Plant Science, Dept Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN, USA.
  • 2011 - 2016 Professor and Sixth Century Chair of Plant Science, School of Biological Sciences, University of Aberdeen, Aberdeen, UK.
  • 2012 - 2016 Founder and co-Director of the Centre for Genome Enabled Biology and Medicine, University of Aberdeen, Aberdeen, UK.
  • Aug 2016 Professor of Genome-Enabled Biology, University of Nottingham, Nottingham, UK.

HONORS AND AWARDS

  • Fellow of the Royal Society of Edinburgh (FRSE), 2014.
  • Fellow Society of Biology (FSB), 2013.
  • Fellow of the American Association for the Advancement of Science (AAAS), 2011.
  • Fellow of the Royal Society of Chemistry (FRSC), 2010.
  • The Purdue University Herbert Newby McCoy Award winner, 2010.
  • Critiques and Awards Program, Gold Award for Genomics Explorer exhibit, Association for Communication Excellence, 2010.
  • First prize Interactive Media Award, Science and Engineering Visualization Challenge, NSF/AAAS, 2008 (Science 321: 1767-1775 (Sept 2008) for the Genomics Digital Lab (GDL).
  • World Summit Awards e-Science & Technology winner for the Genomics Digital Lab (GDL), 2009 http://www.wsis-award.org/winners/winners.wbp
  • Purdue University Faculty Scholar 2003 - 2008
  • Nominated by Nature Biotechnology (March 2006) as one of the "thought leaders and technology pioneers" in biotechnology in the past 10 years (Nature Biotech 24: 291).

Teaching Summary

Through his career Professor Salt has taught in both the US and the UK, including teaching Chemistry, Biochemistry, Plant Physiology and Plant Environment Interactions in years 1 - 4. Professor Salt… read more

Research Summary

Professor Salt has a long term track record in understanding the function of the genes and gene networks that regulate the plant ionome [the elemental composition of an organism, tissue or cell],… read more

Recent Publications

The ionomics HUB (iHUB) (http://www.ionomicshub.org/home/PiiMS) is a collaborative web-based workspace that Professor Salt founded and coordinates. The iHUB is designed to maximize community access to large scientific data sets, in a manner that promotes rapid scientific advancement. Data accessible in the iHUB relates to how plants take up over 20 different essential mineral nutrients such as calcium and potassium and potentially toxic trace elements such as cadmium and arsenic from the soil, and the iHUB contains this information on over 250,000 plants. Not only does the iHUB allow easy sharing of data across the internet, it also provides software tools to make it easier to collected data in a format ready for sharing. This sharing can take the form of viewing and downloading data from the iHUB directly, or connecting to the data permanent archived at the iHUB through the incorporation of links in published articles, books and other web-sites. The iHUB is facilitating open communication and exchange of information via the internet for researchers in over 2,000 different cities in over 100 developed and developing nations. The information obtained from the discoveries facilitated by the iHUB are valuable from the point of view of improving crop yields, enhancing agricultural sustainability, and improving food quality for human nutrition.

Through his career Professor Salt has taught in both the US and the UK, including teaching Chemistry, Biochemistry, Plant Physiology and Plant Environment Interactions in years 1 - 4. Professor Salt has also been involved in academic tutoring in the first year and for honors year essays and projects.

Northern Arizona University, US

  • Introductory Chemistry (CHM 151) - Spring 1998)
  • Fundamental Biochemistry (CHM 360) - Spring & Fall 1998, 1999)
  • Biochemistry (CHM 460) - Spring 2000
  • Fundamental Biochemistry Laboratory (CHM 360L) - Spring & Fall 1998, 1999, 2000)

Purdue University, US

  • Plant Physiology (HORT 301) - Fall 2003
  • Planning and Presenting Horticulture Research (HORT 601) - Fall 2008, Fall 2009, Fall 2010

University of Aberdeen, UK

  • Biology for Undergraduates (BI1006) - Autumn 2012, Spring 2015
  • Biological Topics in Plant and Soil Science (BI25P2) - Spring 2012, 2013, 2014, 2015, 2016
  • Plant-Environment Interactions (PL3504) - Spring 2013, 2014, 2015, 2016

University of Nottingham, UK

  • Basic Introduction to Omic Technology (C135P3 /D24007) - 1 lecture, Autumn 2016

Current Research

Professor Salt has a long term track record in understanding the function of the genes and gene networks that regulate the plant ionome [the elemental composition of an organism, tissue or cell], along with the evolutionary forces that shape this regulation. To date Professor Salt has obtained 33 competitive research awards totaling £15 million, and has published 139 peer-reviewed papers that have been cited ~12,000 times (h-index = 54). Professor Salt's pioneering work has led to the novel functional genomics research paradigm of ionomics that combines high-throughput elemental analysis with bioinformatics, genetics and genomics, and using this approach he has identified genes involved in mineral nutrient and trace element homeostasis. Since 2007 Professor Salt has also led the development of the iHUB, an international collaborative e-research environment to enhance our ability to identify and understand the genes and gene networks that function to control the ionome.

ONGOING RESEARCH SUPPORT

  • MYB36 controls differentiation of the endodermis into an ion-selective barrier. BBSRC (PI David E Salt), 01/01/2017 - 31/12/2020, University of Nottingham £514,378
  • Elucidation of the mechanisms controlling heavy metal accumulation in rice based on ionomics and genomics approaches. National Science Foundation Council of China (NSFC) International Collaborative Project (PI Fangjie Zhou, Co-I David E Salt), 01/01/2016 - 31/12/2020, Nanjing Agricultural University ¥3,330,000.
  • Research Program (SRP) Sources and Protracted Effects of Early Life Exposure to Arsenic and Mercury. Project 1 Arsenic uptake, transport and storage in plants. US National Institute of Environmental Health Sciences (PI Mary Lou Guerinot, Co-PI David E Salt), 01/04/2014 - 31/03/2019, University of Nottingham £264,127
  • Mapping radial ion-transport pathways in plant roots with cell-type specific resolution. The Leverhulme Trust (PI David E Salt), 01/08/2014 - 31/07/2017, University of Nottingham £225,631.
  • ERA-CAPS: Plant root diffusional barriers: Genesis and implications for nutrient efficiency and stress tolerance. (PI David E Salt, Co-I Benni Franke, Nico von Wirén, Yann Boursiac, Mark Aarts, Jan K Schjoerring). BBSRC 01/03/2014 - 31/07/2017, Total award €2,075,000, University of Nottingham £485,024.
  • Genome-wide association mapping and landscape scale modelling of heritable ionomic diversity in Arabidopsis thaliana populations, BBSRC (PI David E Salt), 01/09/2013 - 28/02/2017, University of Nottingham £751,233.
  • The genetic basis of natural ionomic variation, US National Institutes of Health (PIs David E Salt, Mary Lou Guerinot and Charlotte Poschenrieder), 01/04/2011 - 31/03/2017, total award $1,390,459, University of Aberdeen subaward £296,646.

Past Research

COMPLETED RESEARCH SUPPORT

  • The iHUB: A collaborative international network for ionomics, US National Science Foundation (PI David E Salt, Co-I Mourad Ouzzani), 01/06/2010 - 31/05/2016, Purdue University $527,339
  • ALERT 14: Empowering research with ultra-fast high-throughput genome sequencing on the benchtop. BBSRC (PI David E Salt, Co-I Elaina Collie-Duguid), 01/10/2014 - 30/09/2015, University of Aberdeen £529,609
  • US-Brazilian Rice Ionomics Collaborative (USBRIC), US National Science Foundation, Developing Country Collaborations in Plant Genome Research (DCC-PGR) (PI David E Salt), 01/08/2008 - 31/07/2015, Purdue University $95,500
  • Ionome to Genome: Mapping the Gene Networks Controlling Nutrient Content in Rice grain, US National Science Foundation, Plant Genome Research program special creativity extension, (PI David E Salt, CoPI's Mary Lou Guerinot, Shannon Pinson), 09/09/2011 - 31/07/2015, total award $1,454,950, University of Aberdeen subaward £351,928.
  • The genetic basis and adaptive significance of natural ionomic variation, FP7 Marie Curie Career Integration Grant (CIG) (PI David E Salt), 11/08/2011 - 10/08/2015, University of Aberdeen €100,000
  • Ionome to Genome: Mapping the Gene Networks Controlling Nutrient Content in Rice grain, US National Science Foundation, Plant Genome Research program (PI David E Salt, CoPI's Mary Lou Guerinot, Shannon Pinson), 08/14/2007 - 08/13/2012, Purdue University $6,680,415
  • Mechanisms underlying arsenic tolerance and hyperaccumulation in the fern Pteris vittata, US National Science Foundation (PI Jody Banks, CoPI David E Salt), 02/15/2009 - 01/31/2012, Purdue University $400,000
  • Cyberinfrastructure to enabled plant adaptation research, NSF supported iPlant Collaborative (PI David E Salt), 01/01/2011 - 31/3/2012, Purdue University $68,005
  • Tools to Facilitate Collaboration within the Virtual Ionomics Network at ionomicshub.org to Foster Ionomic Discovery, Purdue University Cyber Center (PI David E Salt, CoPI Ivan Baxter), 01/01/2009 - 12/31/2009, $49,000
  • The Genetic basis of natural ionomic variation, National Institutes of Health (PI David E Salt, CoPI Mary Lou Guerinot, Magnus Nordborg), 01/08/2010 - 12/31/2010, $135,175
  • Arsenic Uptake, Transport and Accumulation in Plants project #9, National Institutes of Health. This is a Program Project grant lead by PI Joshua Hamilton entitled "Toxic Metals in the Northeast: From Biological to Environmental Implications (Project #9 PI Mary Lou Guerinot, coPI David E Salt), 04/08 - 03/13, $208,690
  • The Genetic basis of natural ionomic variation, National Institutes of Health (PI David Salt, CoPI Mary Lou Guerinot, Magnus Nordborg), 03/31/2007 - 03/30/2010, $1,086,788
  • Acquisition of Metabolic Profiling Instrumentation at Purdue, National Science Foundation, MRI, (PI Clint Chapple, CoPI's David Rhodes, David Salt, Barry Wanner), 10/01/04 - 09/30/07, Purdue award $839,427.
  • Tools for differential metabolomics, National Institute of Health Road Map, (PI Fred Regnier, CoPI's Jiri Adamec, Graham Cook, Jo Davisson, John Morgan, Dan Raftery, David Salt, Barry Wanner), 10/01/04 - 09/30/07, Purdue award $4,719,117 (Salt budget $778,107).
  • Ionomics. National Science Foundation, 2010 Project, (Pi Guerinot M-L, CoPI's Harper J, Salt DE Schroeder J, Ward J), 9/1/2004 to 8/31/2008, Purdue award $1,222,015 (total $3,490,000).
  • Molecular dissection of arsenic hyperaccumulation in the fern Pteris vittata US Department of Energy (PI Banks J, CoPI Salt DE), 9/01/2003 to 8/31/2006, $450,000
  • Center for Phytoremediation Research and Development. Fund for the 21st Century (PI David E Salt, CoPI Kathy Banks) 07/01/2003 to 06/30/2007, $2,000,000.
  • Monitoring Phytoremediation Processes Using the Green Fluorescent Protein. Department of Energy, Small Business Technology Transfer Program, Phase II, (PI David E Salt ) 9/01/2002 to 8/31/2004, $500,000 Purdue award $350,000.
  • Characterization of potential cesium binding ligands in plant root exudates. Brookhaven National Laboratory (PI David E Salt),01/01/2002 to 05/31/2002, $15,315
  • Monitoring Phytoremediation Processes Using the Green Fluorescent Protein. Department of Energy, Small Business Technology Transfer Program, Phase I (PI David E Salt ), 9/01/2001 to 6/30/2002, $99,791.44, Purdue award $56,853.
  • Genome-wide hunt for metal hyperaccumulation genes. National Science Foundation, Integrative Plant Biology (PI David E Salt ), 7/1/2001 to 6/30/2004, $450,000
  • Selenium enriched plant material for chemoprevention. National Institute of Health, Department of Health and Human Services, National Cancer Institute, Small Business Technology Transfer Program, Phase II (PI David E Salt), 5/1/2001 to 5/2/2003, $399,273 Purdue $169,498
  • Molecular mechanisms of nickel hyperaccumulation in Thlaspi goesingense. National Science Foundation, Integrative Plant Biology (PI David E Salt), 6/01/2001 to 5/31/2004, $329,807
  • Gene discovery in aid of plant nutrition, human health and environmental remediation. National Science Foundation, Plant Functional Genomics (Pi Guerinot M-L, CoPI's Schroeder J, Harper J, Eide D, Salt DE), 9/1/2000 to 8/31/2004, Purdue award $689,611 (total $4,414,644).
  • Selenium enriched plant material for chemoprevention, National Institute of Health, Department of Health and Human Services, National Cancer Institute, Small Business Technology Transfer Program, Phase I (PI David E Salt), 1/1/99 to 12/31/2000, $100,000.
  • Molecular dissection of the cellular mechanisms involved in nickel hyperaccumulation in plants, US Department of Energy (PI David E Salt), 9/15/96 to 01/31/2000, $495,938.
  • Phytofiltration: A novel approach to water treatment using seedlings, US Department of Agriculture (PI David E Salt), 12/1/96 to 4/30/2000, $116,664.

COMPLETED TEACHING GRANTS

  • Genomics Revolution Uncloaked American Society of Plant Biologists, Education Foundation (PI David E Salt), 08/01/2005, $30,000
  • Chemistry and genomics-driven drug discovery. The Camille and Henry Dreyfus Foundation, Inc., Special Grant Program in the Chemical Sciences, 01/27/00, $25,199 (PI David E Salt, CoPI with Dr Paul Torrence and Dr Colleen Kelley).
  • A day in the life of a protein- The green fluoresecent protein as a laboratory teaching aid. National Science Foundation, Course, Curriculum and Laboratory Improvement (CCLI) (PI David E Salt), 09/01/99 to 08/31/2001, $91, 671 (NAU match of $94,524, providing a total of $186,195).
  • John Freeman, Hooper Undergraduate Research Program, Spring 2000, $2,191
  • Isaac Shaffer, NASA Space Grant Internship, 1999-2000, $2,500.
  • Kenneth Nieman, Hooper Undergraduate Research Program, Spring 1999, $1,260.
  • Pam Motley, Achievement Rewards for College Scientists (ARCS) Scholarship, 1998, $6,000.
  • Exxon Company travel grant to support speaker participation at the Phytoremediation Special Symposium at the 5th International Conference on the Biogeochemistry of Trace Elements, Vienna, Austria, 1999, $1,000.
  • Research Apprenticeship Program for Minority High School Students, 1994, $1,975.

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