Sian Bray

Contact

• workRoom B61 Life Sciences
  University Park
  Nottingham
  NG7 2RD
  UK
• Sian.Bray@nottingham.ac.uk

Biography

I am fascinated by evolution. My work focuses on the evolutionary genomics underlying adaptation. I have a range of skills including 'dry-lab' bioinformatic and programming skills as well as 'wet-lab' biochemistry and structural biology skills.

Teaching Summary

I am also heavily involved in the design and delivery of Nottingham's new MSc course in Bioinformatics.

Research Summary

The main research interest of my lab is genomic and proteomic evolution in response to stressful or extreme conditions, via high-resolution large-scale genomic analyses, as well as protein structural… read more

Recent Publications

• ZABOLOTNAYA E, MELA I, WILLIAMSON MJ, BRAY SM, YAU SK, PAPATZIAMOU D, EDWARDSON JM, ROBINSON NP and HENDERSON RM, 2020. Modes of action of the archaeal Mre11/Rad50 DNA-repair complex revealed by fast-scan atomic force microscopy. Proceedings of the National Academy of Sciences of the United States of America. 117(26), 14936-14947
• RISA, GABRIEL TARRASON, HURTIG, FREDRIK, BRAY, SIAN, HARKER-KIRSCHNECK, HARKER-KIRSCHNECK, LENA, FAULL, PETER, DAVIS, COLIN, PAPATZIAMOU, DIMITRA, MUTAVCHIEV, DELYAN R., FAN, CATHERINE, MENEGUELLO, LETICIA, PULSCHEN, ANDRE ARASHIRO, DEY, GAUTAM, CULLEY, SIAN, KILKENNY, MAIRI, PELLEGRINI, LUCA, DE BRUIN, ROBERTUS A. M., HENRIQUES, RICARDO, SNIJDERS, AMBROSIUS P, SARIC, ANDJELA, LINDR AS, ANN-CHRISTIN, ROBINSON, NICK and BAUM, BUZZ, 2019. Proteasome-mediated protein degradation resets the cell division cycle and triggers ESCRT-III-mediated cytokinesis in an archaeon bioRxiv.
• BADUEL, PIERRE, BRAY, SIAN, VALLEJO-MARIN, MARIO, KOLÁŘ, FILIP and YANT, LEVI, 2018. The “Polyploid Hop”: Shifting Challenges and Opportunities Over the Evolutionary Lifespan of Genome Duplications Frontiers in Ecology and Evolution. 6, 117
• BUSOMS, SILVIA, PAAJANEN, PIRITA, MARBURGER, SARAH, BRAY, SIAN, HUANG, XIN-YUAN, POSCHENRIEDER, CHARLOTTE, YANT, LEVI and SALT, DAVID E., 2018. Fluctuating selection on migrant adaptive sodium transporter alleles in coastal Arabidopsis thaliana Proceedings of the National Academy of Sciences. 115(52), E12443-E12452

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Current Research

The main research interest of my lab is genomic and proteomic evolution in response to stressful or extreme conditions, via high-resolution large-scale genomic analyses, as well as protein structural modelling and functional predictions. This work has recently branched out into computational methods development via the work of my previous postdoc and a fruitful collaboration.

• ZABOLOTNAYA E, MELA I, WILLIAMSON MJ, BRAY SM, YAU SK, PAPATZIAMOU D, EDWARDSON JM, ROBINSON NP and HENDERSON RM, 2020. Modes of action of the archaeal Mre11/Rad50 DNA-repair complex revealed by fast-scan atomic force microscopy. Proceedings of the National Academy of Sciences of the United States of America. 117(26), 14936-14947
• RISA, GABRIEL TARRASON, HURTIG, FREDRIK, BRAY, SIAN, HARKER-KIRSCHNECK, HARKER-KIRSCHNECK, LENA, FAULL, PETER, DAVIS, COLIN, PAPATZIAMOU, DIMITRA, MUTAVCHIEV, DELYAN R., FAN, CATHERINE, MENEGUELLO, LETICIA, PULSCHEN, ANDRE ARASHIRO, DEY, GAUTAM, CULLEY, SIAN, KILKENNY, MAIRI, PELLEGRINI, LUCA, DE BRUIN, ROBERTUS A. M., HENRIQUES, RICARDO, SNIJDERS, AMBROSIUS P, SARIC, ANDJELA, LINDR AS, ANN-CHRISTIN, ROBINSON, NICK and BAUM, BUZZ, 2019. Proteasome-mediated protein degradation resets the cell division cycle and triggers ESCRT-III-mediated cytokinesis in an archaeon bioRxiv.
• BADUEL, PIERRE, BRAY, SIAN, VALLEJO-MARIN, MARIO, KOLÁŘ, FILIP and YANT, LEVI, 2018. The “Polyploid Hop”: Shifting Challenges and Opportunities Over the Evolutionary Lifespan of Genome Duplications Frontiers in Ecology and Evolution. 6, 117
• BUSOMS, SILVIA, PAAJANEN, PIRITA, MARBURGER, SARAH, BRAY, SIAN, HUANG, XIN-YUAN, POSCHENRIEDER, CHARLOTTE, YANT, LEVI and SALT, DAVID E., 2018. Fluctuating selection on migrant adaptive sodium transporter alleles in coastal Arabidopsis thaliana Proceedings of the National Academy of Sciences. 115(52), E12443-E12452
• SCHMICKL, ROSWITHA, MARBURGER, SARAH, BRAY, SIAN and YANT, LEVI, 2017. Hybrids and horizontal transfer: introgression allows adaptive allele discovery JOURNAL OF EXPERIMENTAL BOTANY. 68(20), 5453-5470
• ANJUM RS, BRAY SM, BLACKWOOD JK, KILKENNY ML, COELHO MA, FOSTER BM, LI S, HOWARD JA, PELLEGRINI L, ALBERS SV, DEERY MJ and ROBINSON NP, 2015. Involvement of a eukaryotic-like ubiquitin-related modifier in the proteasome pathway of the archaeon Sulfolobus acidocaldarius. Nature communications. 6, 8163
• RZECHORZEK NJ, BLACKWOOD JK, BRAY SM, MAMAN JD, PELLEGRINI L and ROBINSON NP, 2014. Structure of the hexameric HerA ATPase reveals a mechanism of translocation-coupled DNA-end processing in archaea. Nature communications. 5, 5506
• BLACKWOOD JK, RZECHORZEK NJ, BRAY SM, MAMAN JD, PELLEGRINI L and ROBINSON NP, 2013. End-resection at DNA double-strand breaks in the three domains of life. Biochemical Society transactions. 41(1), 314-20