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Joshua Petch

Postgraduate Research Student, Faculty of Science

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Biography

I gained my undergraduate degree in Biomedical Science from Staffordshire University in 2014. This included a final year project investigating the regulation of the Vibriio fischeri Lux Operon.

Immediately following completion of my degree I joined the University of Birmingham to undertake a Master's in Molecular Biotechnology. This included a four month research placement within the Institute of Microbiology and Infection under the supervision of Dr David Lee investigating the effect of Deoxyadenosine methylase (DAM) activity upon transcription activation by the global transcription regulator cyclic AMP receptor protein (CRP).

In October 2015 I joined the School of Pharmacy as a PhD student under the SynBio Doctoral Training Programme.

Research Summary

Project Title: The use of synthetic biology to fish out bacteria form sequential metabolic reactions

Supervisors: Dr Giuseppe Mantovani

Professor Miguel Camara

Dr Stephan Heeb

Summary:

The use of synthetic biology to generate bacterial strains with useful properties or engineered metabolic pathways has revolutionised a range of industrial sectors, from healthcare and pharmaceuticals to industrial biotechnology. Such strains are able to synthesise a product of interest with few resources at much greater efficiencies than can be achieved by synthetic means and consequently they are becoming increasingly more prevalent in industry, which the potential to replace older procedures.

However the ability of a bacterial population to generate a product or perform a function of interest can be marred by the mix of strain or organisms with different properties within that population; the selective sequestration of specific bacterial strains/species from a mixed population may offer a solution to this issue.

We aim to develop a novel selective sequestration platform by the engineering of novel bacterial strains which display carbohydrate binding proteins (lectins) on their surface under the control of inducible promoters in tandem with the synthesis of polymers which display appropriate carbohydrate ligands.

Centre for Biomolecular Sciences

University of Nottingham
University Park
Nottingham, NG7 2RD

telephone: +44 (0) 115 846 8001
fax: +44 (0) 115 846 8002
email: CBS Enquiries