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Philemon Gyasi-Antwi

Research Fellow, Faculty of Medicine & Health Sciences

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Biography

Philemon Gyasi-Antwi is a BBSRC Research Fellow at the Translational Medical Sciences Unit of the School of Medicine, University of Nottingham (2021 -). He is working on a cross-disciplinary project to investigate the interplay between lung epithelial cells and macrophages during SARS-CoV-2 infection.

Philemon graduated with a BSc in Biological Sciences from the Kwame Nkrumah University of Science and Technology, Ghana, in 2010. He then proceeded to the University of Oxford to undertake a Master's degree in Integrated Immunology in 2012. At Oxford, he developed a research interest in host-pathogen interactions and joined Professor Peter Beverley and Dr Elma Tchilian's lab to investigate the immunogenicity of a Cytomegalovirus-based vaccine candidate (MCMV85A) against Mycobacterium tuberculosis. He then moved to the University of Nottingham in 2014- and completed his PhD in 2018 investigating the role of hxc-type II secretion system of Pseudomonas aeruginosa during pathogenesis under the supervision of Dr Luisa Martinez-Pomares and Professor Miguel Camara. After his PhD, Philemon took Research Fellowship posts in a multidisciplinary diabetes research group led by Dr Gary Adams to (1) develop an innovative pre-screening tool for the management of gestational diabetes in Ghana (2018-2019) and (2) to develop novel antimicrobial-polymeric formulations for wound healing applications in diabetic patients with deleterious injuries (2019-2020).

Expertise Summary

  • Immunoassay Development: Multi-parameter Flow cytometry, ELISpot, ELISA, and Luminex multiplex assays, Immunohistochemistry
  • Molecular Assay: PCR, Mutagenesis, Primer design, genomic DNA purification, Plasmid generation, Promoter-reporter analysis
  • Cell Culture: Undifferentiated and Differentiated (Air-Liquid interface) human bronchial epithelial cell models
  • Microscopy: Confocal, SEM

Research Summary

Research Interests:

Host-pathogen interactions (Inflammatory response of adaptive and innate immune cells to pathogens) and Vaccine development.

Recent Publications

  • ASHWAQ H. ALSHMIMRY, SHAHWAR IMRAN JIWANI, PHILEMON GYASI-ANTWI AND GARY G. ADAMS, 2021. Effectiveness and Safety of Hyperbaric Oxygen Therapy (HBOT) in Treating Diabetic Foot Ulcers (DFUs) Current Research in Clinical Diabetes and Obesity. 1(1), 1-14
  • GILLIS, RICHARD B., SOLOMON, HODAYA, V, GOVADA, LATA, OLDHAM, NEIL J., DINU, VLAD, JIWANI, SHAHWAR IMRAN, GYASI-ANTWI, PHILEMON, COFFEY, FRANK, MEAL, ANDY, MORGAN, PAUL S., HARDING, STEPHEN E., HELLIWELL, JOHN R., CHAYEN, NAOMI E. and ADAMS, GARY G., 2021. Analysis of insulin glulisine at the molecular level by X-ray crystallography and biophysical techniques SCIENTIFIC REPORTS. 11(1),
  • JENNIFER WALLACE, SHAHWAR JIWANI, PHILEMON GYASI-ANTWI, ANDREW MEAL, GARY G. ADAMS, 2020. Management of Diabetes Patients across the Peri- Operative Pathway: A Systematic Review Endocrinol Diabetes Metab J,. 4(1), 1-16
  • SHAHWAR IMRAN JIWANI, SHA HAUNG, ORITSEGIDENENE BEJI, PHILEMON GYASI-ANTWI, RICHARD GILLIS, GARY ADAMS, 2020. Clinically relevant Insulin Degludec and its interaction with polysaccharides: a biophysical examination Polymers. 12, 390

Past Research

*Application of biopolymers for drug delivery and wound healing.

*Field-based interventional study for Gestational diabetes management.

  • ASHWAQ H. ALSHMIMRY, SHAHWAR IMRAN JIWANI, PHILEMON GYASI-ANTWI AND GARY G. ADAMS, 2021. Effectiveness and Safety of Hyperbaric Oxygen Therapy (HBOT) in Treating Diabetic Foot Ulcers (DFUs) Current Research in Clinical Diabetes and Obesity. 1(1), 1-14
  • GILLIS, RICHARD B., SOLOMON, HODAYA, V, GOVADA, LATA, OLDHAM, NEIL J., DINU, VLAD, JIWANI, SHAHWAR IMRAN, GYASI-ANTWI, PHILEMON, COFFEY, FRANK, MEAL, ANDY, MORGAN, PAUL S., HARDING, STEPHEN E., HELLIWELL, JOHN R., CHAYEN, NAOMI E. and ADAMS, GARY G., 2021. Analysis of insulin glulisine at the molecular level by X-ray crystallography and biophysical techniques SCIENTIFIC REPORTS. 11(1),
  • JENNIFER WALLACE, SHAHWAR JIWANI, PHILEMON GYASI-ANTWI, ANDREW MEAL, GARY G. ADAMS, 2020. Management of Diabetes Patients across the Peri- Operative Pathway: A Systematic Review Endocrinol Diabetes Metab J,. 4(1), 1-16
  • SHAHWAR IMRAN JIWANI, SHA HAUNG, ORITSEGIDENENE BEJI, PHILEMON GYASI-ANTWI, RICHARD GILLIS, GARY ADAMS, 2020. Clinically relevant Insulin Degludec and its interaction with polysaccharides: a biophysical examination Polymers. 12, 390
  • AMEERA AL ONEZEI, SHAHWAR I JIWANI, PHILEMON GYASI-ANTWI, ANDREW MEAL AND GARY G ADAMS, 2020. Is Liraglutide a Safe and Effective Medication to Treat Hyperglycaemia? A Systematic Review Annals of Clinical Diabetes and Endocrinology. 3(2), 1017
  • BEJI, ORITSEGIDENENE, GILLIS, RICHARD B., DINU, VLAD, JIWANI, SHAHWAR, I, GYASI-ANTWI, PHILEMON, FISK, IAN D., MEAL, ANDREW, MORGAN, PAUL S., HARDING, STEPHEN E., HUANG, SHA, AGUGINI, GIULIA, FEDELE, FEDERICA and ADAMS, GARY G., 2020. Exploration of temperature and shelf-life dependency of the therapeutically available Insulin Detemir EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 152, 340-347
  • GYASI-ANTWI, PHILEMON, WALKER, L, MOODY, C, OKYERE, S, SALT, K, ANANG, L, EDUFUL, E, LARYEA, D, OTTIE-BOAKYE, D and ASAH-OPOKU, K, Global Prevalence of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis: New American Journal of Medicine New American Journal of Medicine. 1(3),

School of Health Sciences

B236, Medical School
Queen's Medical Centre
Nottingham, NG7 2HA

telephone: +44 (0)115 95 15559
email: mhssupport@nottingham.ac.uk