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Research Associate/Fellow (Fixed Term)

Reference
MED439516X3
Closing Date
Wednesday, 22nd November 2017
Job Type
Research
Department
Life Sciences
Salary
£26495 to £30688 per annum, depending on skills and experience (minimum £29799 with relevant PhD).

Applications are invited for this 3-year postdoctoral fellowship in membrane biophysics as part of a prestigious £3.17M BBSRC-funded project. The project involves collaborations with the University of York, Sheffield, Cambridge and Exeter, as well as with our industrial partners, Lucite, Green Biologics, Ingenza and CPI. 

Your challenge is to characterise changes in membrane structure, sensitivity and tolerance to a range of chemicals, and to work collaboratively with the molecular biology team, who will engineer bacterial superstrain nanofactory for enhanced productivity and tolerance. The work involves characterising membrane stability following directed evolution, as well as changes in membrane protein structure and function that lead to resistance. Membrane studies include solid state and DNP NMR, SAXS, CD and MD simulations. Protein engineering of recombinant proteins will be used to modulate membrane function and stability and design bacterial strains with enhanced resistance.

We seek highly motivated and creative candidates who should have or expect to obtain a PhD in molecular microbiology, biophysics, biochemistry, structural biology or related field. Candidates with experience in experimental membrane biophysics, biomolecular NMR and membrane proteins are particularly encouraged to apply. Additional experience in computational biology is desirable. Excellent verbal and written communication skills are essential and you must be able to work in a multidisciplinary team.

The environment:

The University of Nottingham is a research-led institution with a world-leading reputation in magnetic resonance. You will join the Biomembrane NMR lab, which works in close collaboration with the Faculty of Engineering and the Microbiology Division within the School of Life Sciences at Nottingham. The group is well equipped with in-house 400 MHz solid state NMR system, configured for membrane work and a GPU-server for MD simulations along with protein and peptide production and purification wet lab. As a key partner in the new £2.5M 600 MHz DNP NMR Facility at Nottingham, the group has regular use of the system. We also have access to the 800 MHz and a number of lower field solution NMR systems.Work in the lab is highly collaborative and the lab is a major user of the Nottingham HPC, the new HPC Midlands Plus and has regular access to Diamond and ISIS.

This full-time fixed-term post is available for a period of 3 years.

The School of Life Sciences holds an Athena Silver SWAN Award, in recognition of our commitment to supporting and advancing women’s careers in the life sciences (STEMM). You can read more about this initiative at http://www.nottingham.ac.uk/life-sciences/documents/athena-swan-silver-award.pdf

Informal enquiries may be addressed to Dr Bonev, boyan.bonev@nottingham.ac.uk or via www.bonev.org. Please note that applications sent directly to this email address will not be accepted.

The University of Nottingham is an equal opportunities employer and welcomes applications from all sections of the community.