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Research Associate/Fellow in Flow-Biocatalysis (Fixed-term)

Reference
SCI038418
Closing Date
Wednesday, 28th February 2018
Job Type
Research
Department
Organic Chemistry
Salary
£26495 to £32548 per annum, depending on skills and experience (minimum £29799 with relevant PhD)

We are seeking a motivated and creative postdoctoral Research Associate/Fellow to work on an on-going project entitled “Halophilic enzymes in tandem flow reactions”. The project is BBSRC-funded and the goal is to combine different enzymes to perform multiple transformations in a flow bioreactor. For example, we intend to generate amines (and other valuable chemicals) from alcohols via carbonyl intermediates. Amines are key functional groups of numerous intermediates for pharmaceutical and agrochemical applications, and enzymatic synthesis offers a 'green' alternative to traditional methodologies.

To overcome the limitations of mesophilic enzymes such as low stability in organic solvents, the project will focus on halophilic biocatalysts that offer remarkable stability and excellent substrate scope. Currently we are using two enzymes (an alcohol dehydrogenases and an amino transaminase) from a haloadapted and halophilic organisms. The enzymes will be individually covalently immobilized on a solid support and optimised in a flow system where the product of the first enzyme acts as the substrate for the second one. Factors such as the recycling of the cofactor in situ and optimal reactions rate are key to the success of the project.

The person appointed will join the research groups of Drs Francesca Paradisi and Thorsten Allers, who have a track record of productive collaboration on halophilic enzymes. The person appointed will be expected to plan, conduct and analyse research in this area and will be responsible for writing up work for publication and presentation at scientific meetings

Candidates must hold, or be near to completion of, a PhD (or equivalent) in chemical biology, enzymology, biochemistry. It is essential that they have demonstrated outstanding skills in a wide variety of laboratory techniques, including enzymology, biochemistry, chemical biology, and ideally, flow biocatalysis. Basic knowledge of characterisation of molecules is desirable. Applications from strong candidates with a track-record of research in enzymology and enzyme-mediated biotransformations, flow-biocatalysis, including publications in these areas, are particularly encouraged.

This full-time fixed-term role is available from the 1 April 2018 or as soon as possible thereafter for a period of 21 months. 

The School values diversity and is committed to equality of opportunity.The School of Chemistry holds a Bronze Athena SWAN Award in recognition of our commitment to advancing women's careers in science. You can read more about what this means athttp://www.athenaswan.org.uk/ and on our website http://www.nottingham.ac.uk/chemistry/about/athena-swan.aspx

Informal enquiries may be addressed to Dr Francesca Paradisi, tel. 0115 748 6267 or email: francesca.paradisi@nottingham.ac.uk or Dr Thorsten Allers. tel. 0115 823 0304 or email: thorsten.allers@nottingham.ac.uk. Please note that applications sent directly to these email addresses will not be accepted. Additional information on our research activities can be found at www.paradisiresearch.com or http://www.nottingham.ac.uk/life-sciences/people/thorsten.allers

The University of Nottingham is an equal opportunities employer and welcomes applications from all sections of the community.