Mechanistic studies of the transition from acute to chronic pain in osteoarthritis models
Examining the central and peripheral mechanisms involved in mediating the transition from acute to chronic pain in clinically-relevant animal models of osteoarthritis. These mechanisms will be investigated using both in vivo and ex vivo techniques. A focus on single-unit spinal electrophysiology explores functional changes, supported by immunohistochemistry to probe anatomical changes. Currently, changes in spinal GABAergic signalling in the mono-iodoacetate model of OA pain are being explored using both agonists and antagonists of the GABAA receptor.
This work is done within the Arthritis Research UK Pain Centre and funded by ARUK
Prof Victoria Chapman
Dr Gareth Hathway
Prof Lucy Donaldson
University of NottinghamMedical School
Queen's Medical CentreNottingham NG7 2UH
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