School of Life Sciences
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Lydia Sinnett-Smith

PhD Student,

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Research Summary

Mechanistic studies of the transition from acute to chronic pain in osteoarthritis models

Examining the central and peripheral mechanisms involved in mediating the transition from acute to chronic pain in clinically-relevant animal models of osteoarthritis. These mechanisms will be investigated using both in vivo and ex vivo techniques. A focus on single-unit spinal electrophysiology explores functional changes, supported by immunohistochemistry to probe anatomical changes. Currently, changes in spinal GABAergic signalling in the mono-iodoacetate model of OA pain are being explored using both agonists and antagonists of the GABAA receptor.

This work is done within the Arthritis Research UK Pain Centre and funded by ARUK

Supervisors:

Prof Victoria Chapman

Dr Gareth Hathway

Prof Lucy Donaldson

Recent Publications

School of Life Sciences

University of Nottingham
Medical School
Queen's Medical Centre
Nottingham NG7 2UH

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