Associate Professor in Pharmacology, Faculty of Medicine & Health Sciences
My main research interest lies in understanding how nutrients regulate insulin secretion.
Stimulus-secretion coupling in the islet B-cell is well-researched but our knowledge remains limited in many areas with this very complex system, in which metabolism is closely tied into insulin biosynthesis and exocytosis. The research aim of the group is to generate information to provide for a richer understanding of the control of insulin secretion and thus, ultimately, for the development of new and strategically-targetted therapeutic agents to regulate the release of insulin.
More recent research interests are investigations into control of adipocyte functions (role of intracellular calcium, insulin resistance), of vascular tone (pharmacology), and of respiratory smooth muscle tone (hyperglycaemia and remodelling).
Main teaching activities: human physiology, pharmacology and clinical therapeutics to Life Sciences and MPharm undergraduates and on pre-clinical Medicine degree.
Diabetes Stimulus-secretion coupling and insulin secretion Imidazoline receptors and endogenous ligands ATP-sensitive potassium channels Adrenoceptors
University of NottinghamMedical School
Queen's Medical CentreNottingham NG7 2UH
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