School of Life Sciences
 

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Theocharis Tsoleridis

Research Fellow, Faculty of Medicine & Health Sciences

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Biography

I studied Molecular Biology & Genetics at the Democritus University of Thrace, Greece from 2006 to 2010. I obtained my MSc in Molecular Genetics & Diagnostics at the University of Nottingham, UK in 2012. In 2018 I have completed my PhD in Molecular Virology at the University of Nottingham with a full scholarship from BBSRC DTP studying emerging coronaviruses in rodents. I have also worked at the Eberhard Karl University of Tübingen, Germany in 2010 and at the Institute of Virology in Bonn, Germany in 2016 as a visiting scientist.

Since 2018 I have been working as a Research Fellow at the University of Nottingham with Prof Jonathan Ball. I am currently involved in several research projects including virus discovery and evolution, viral entry, molecular epidemiology and cow monoclonal antibodies.

Expertise Summary

My research expertise is focused in three areas: Virus Discovery & Evolution, Viral entry & tropism, Cow monoclonal antibodies.

Virus Discovery & Evolution

We are involved in projects in which we collect animal tissues (mainly rodents) and screen them either with PCR or NGS to discover new viruses. We then try to acquire their full genome and perform phylogenetic analyses to understand their origin and evolution, extending our knowledge of wildlife reservoirs. We currently have active collaborations within the UK, Europe and Central/South America.

We have discovered novel rodent Alphacoronaviruses in Europe ( https://doi.org/10.3390/v8030084 ) that shared a common ancestry with other rodent Alphacoronaviruses from around the world ( https://doi.org/10.3390/v11020125 ). We have also discovered several novel viruses including astroviruses, paramyxoviruses ( https://doi.org/10.3390/v12010047 ) and hantaviruses ( https://doi.org/10.3390/v12040454 ).

Viral entry and tropism

We use a pseudotyping system to generate pseudotypes of enveloped viruses and assess their entry into cells. We have managed to pseudotype several viruses including Hepatitis C (https://jvi.asm.org/content/90/7/3288) , SARS-CoV, SARS-CoV-2, MERS-CoV and Lassa Fever Virus.

We are also involved in projects testing the efficacy of COVID-19 vaccine candidates using pseudotype SARS-CoV-2 neutralisation assays (https://doi.org/10.1016/j.ymthe.2021.04.022).

Selected Publications

  • URBANOWICZ, RICHARD A, TSOLERIDIS, THEOCHARIS, JACKSON, HANNAH J, CUSIN, LOLA, DUNCAN, JOSHUA D, CHAPPELL, JOSEPH G, TARR, ALEXANDER W, NIGHTINGALE, JESSICA, NORRISH, ALAN R, IKRAM, ADEEL, MARSON, BEN, CRAXFORD, SIMON J, KELLY, ANTHONY, AITHAL, GURUPRASAD P, VIJAY, AMRITA, TIGHE, PATRICK J, BALL, JONATHAN K, VALDES, ANA M and OLLIVERE, BENJAMIN J, 2021. Two doses of the SARS-CoV-2 BNT162b2 vaccine enhances antibody responses to variants in individuals with prior SARS-CoV-2 infection. Science translational medicine.
  • CAPONE, STEFANIA, RAGGIOLI, ANGELO, GENTILE, MICHELA, BATTELLA, SIMONE, LAHM, ARMIN, SOMMELLA, ANDREA, CONTINO, ALESSANDRA MARIA, URBANOWICZ, RICHARD A, SCALA, ROMINA, BARRA, FEDERICA, LEUZZI, ADRIANO, LILLI, ELEONORA, MISELLI, GIUSEPPINA, NOTO, ALESSIA, FERRAIUOLO, MARIA, TALOTTA, FRANCESCO, TSOLERIDIS, THEOCHARIS, CASTILLETTI, CONCETTA, MATUSALI, GIULIA, COLAVITA, FRANCESCA, LAPA, DANIELE, MESCHI, SILVIA, CAPOBIANCHI, MARIA, SORIANI, MARCO, FOLGORI, ANTONELLA, BALL, JONATHAN K, COLLOCA, STEFANO and VITELLI, ALESSANDRA, 2021. Immunogenicity of a new gorilla adenovirus vaccine candidate for COVID-19. Molecular therapy : the journal of the American Society of Gene Therapy.
  • TSOLERIDIS T, CHAPPELL JG, MONCHATRE-LEROY E, UMHANG G, SHI M, BENNETT M, TARLINTON RE, MCCLURE CP, HOLMES EC and BALL JK, 2020. Discovery and Prevalence of Divergent RNA Viruses in European Field Voles and Rabbits. Viruses. 12(1),
  • TSOLERIDIS, THEOCHARIS and BALL, JONATHAN K, 2020. Discovery of Novel Coronaviruses in Rodents. Methods in molecular biology (Clifton, N.J.). 2203, 33-40
  • FRANCIS, R. V., BILLAM, H., CLARKE, M., YATES, C., TSOLERIDIS, T., BERRY, L., MAHIDA, N., IRVING, W. L., MOORE, C., HOLMES, N., BALL, J. K., LOOSE, M., MCCLURE, C. P. and COVID- GENOMICS UK CONSORTIUM, 2022. The Impact of Real-Time Whole-Genome Sequencing in Controlling Healthcare-Associated SARS-CoV-2 Outbreaks: J Infect Dis J Infect Dis. 225(1), 10-18
  • HOWSON-WELLS, HANNAH C, TSOLERIDIS, THEOCHARIS, ZAINUDDIN, IZZAH, TARR, ALEXANDER W, IRVING, WILLIAM L, BALL, JONATHAN K, BERRY, LOUISE, CLARK, GEMMA and MCCLURE, C PATRICK, 2022. Enterovirus D68 epidemic, UK, 2018, was caused by subclades B3 and D1, predominantly in children and adults, respectively, with both subclades exhibiting extensive genetic diversity. Microbial genomics. 8(5),
  • ADEBOYEJO, KAZEEM, KING, BARNABAS J, TSOLERIDIS, THEOCHARIS, TARR, ALEXANDER W, MCLAUCHLAN, JOHN, IRVING, WILLIAM L, BALL, JONATHAN K and MCCLURE, C PATRICK, 2022. Hepatitis C subtyping assay failure in UK patients born in sub-Saharan Africa: Implications for global treatment and elimination. Journal of medical virology.
  • VOLZ, ERIK, HILL, VERITY, MCCRONE, JOHN T, PRICE, ANNA, JORGENSEN, DAVID, O'TOOLE, AINE, SOUTHGATE, JOEL, JOHNSON, ROBERT, JACKSON, BEN, NASCIMENTO, FABRICIA F, REY, SARA M, NICHOLLS, SAMUEL M, COLQUHOUN, RACHEL M, DA SILVA FILIPE, ANA, SHEPHERD, JAMES, PASCALL, DAVID J, SHAH, RAJIV, JESUDASON, NATASHA, LI, KATHY, JARRETT, RUTH, PACCHIARINI, NICOLE, BULL, MATTHEW, GEIDELBERG, LILY, SIVERONI, IGOR, GOODFELLOW, IAN, LOMAN, NICHOLAS J, PYBUS, OLIVER G, ROBERTSON, DAVID L, THOMSON, EMMA C, RAMBAUT, ANDREW and CONNOR, THOMAS R, 2021. Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity. Cell. 184(1), 64-75.e11
  • CAPONE, STEFANIA, RAGGIOLI, ANGELO, GENTILE, MICHELA, BATTELLA, SIMONE, LAHM, ARMIN, SOMMELLA, ANDREA, CONTINO, ALESSANDRA MARIA, URBANOWICZ, RICHARD A, SCALA, ROMINA, BARRA, FEDERICA, LEUZZI, ADRIANO, LILLI, ELEONORA, MISELLI, GIUSEPPINA, NOTO, ALESSIA, FERRAIUOLO, MARIA, TALOTTA, FRANCESCO, TSOLERIDIS, THEOCHARIS, CASTILLETTI, CONCETTA, MATUSALI, GIULIA, COLAVITA, FRANCESCA, LAPA, DANIELE, MESCHI, SILVIA, CAPOBIANCHI, MARIA, SORIANI, MARCO, FOLGORI, ANTONELLA, BALL, JONATHAN K, COLLOCA, STEFANO and VITELLI, ALESSANDRA, 2021. Immunogenicity of a new gorilla adenovirus vaccine candidate for COVID-19. Molecular therapy : the journal of the American Society of Gene Therapy.
  • GRAHAM, MARK S., SUDRE, CAROLE H., MAY, ANNA, ANTONELLI, MICHELA, MURRAY, BENJAMIN, VARSAYSKY, THOMAS, KLASER, KERSTIN, CANAS, LIANE S., MOLTENI, ERIKA, MODAT, MARC, DREW, DAVID A., NGUYEN, LONG H., POLIDORI, LORENZO, SELVACHANDRAN, SOMESH, HU, CHRISTINA, CAPDEVILA, JOAN, HAMMERS, ALEXANDER, CHAN, ANDREW T., WOLF, JONATHAN, SPECTOR, TINS D., STEVES, CLAIRE J. and OURSELIN, SEBASTIEN, 2021. Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study LANCET PUBLIC HEALTH. 6(5), E335-E345
  • VOLZ, ERIK, MISHRA, SWAPNIL, CHAND, MEERA, BARRETT, JEFFREY C., JOHNSON, ROBERT, GEIDELBERG, LILY, HINSLEY, WES R., LAYDON, DANIEL J., DABRERA, GAVIN, TOOLE, AINE O., AMATO, ROBERT, RAGONNET-CRONIN, MANON, HARRISON, IAN, JACKSON, BEN, ARIANI, CRISTINA, V, BOYD, OLIVIA, LOMAN, NICHOLAS J., MCCRONE, JOHN T., GONCALVES, SONIA, JORGENSEN, DAVID, MYERS, RICHARD, HILL, VERITY, JACKSON, DAVID K., GAYTHORPE, KATY, GROVES, NATALIE, SILLITOE, JOHN, KWIATKOWSKI, DOMINIC P., FLAXMAN, SETH, RATMANN, OLIVER, BHATT, SAMIR, HOPKINS, SUSAN, GANDY, AXEL, RAMBAUT, ANDREW and FERGUSON, NEIL M., 2021. Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England NATURE. 593(7858), 266-+
  • COLLIER, DAMI A., DE MARCO, ANNA, FERREIRA, ISABELLA A. T. M., MENG, BO, DATIR, RAWLINGS P., WALLS, ALEXANDRA C., KEMP, STEVEN A., BASSI, JESSICA, PINTO, DORA, SILACCI-FREGNI, CHIARA, BIANCHI, SIRO, TORTORICI, M. ALEJANDRA, BOWEN, JOHN, CULAP, KATJA, JACONI, STEFANO, CAMERONI, ELISABETTA, SNELL, GYORGY, PIZZUTO, MATTEO S., PELLANDA, ALESSANDRA FRANZETTI, GARZONI, CHRISTIAN, RIVA, AGOSTINO, ELMER, ANNE, KINGSTON, NATHALIE, GRAVES, BARBARA, MCCOY, LAURA E., SMITH, KENNETH G. C., BRADLEY, JOHN R., TEMPERTON, NIGEL, CERON-GUTIERREZ, LOURDES, BARCENAS-MORALES, GABRIELA, HARVEY, WILLIAM, VIRGIN, HERBERT W., LANZAVECCHIA, ANTONIO, PICCOLI, LUCA, DOFFINGER, RAINER, WILLS, MARK, VEESLER, DAVID, CORTI, DAVIDE and GUPTA, RAVINDRA K., 2021. Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies NATURE. 593(7857), 136-+
  • CHAPPELL, JOSEPH G, TSOLERIDIS, THEOCHARIS, CLARK, GEMMA, BERRY, LOUISE, HOLMES, NADINE, MOORE, CHRISTOPHER, CARLILE, MATTHEW, SANG, FEI, DEBEBE, BISRAT J, WRIGHT, VICTORIA, IRVING, WILLIAM L, THOMSON, BRIAN J, BOSWELL, TIMOTHY C J, WILLINGHAM, IONA, JOSEPH, AMELIA, SMITH, WENDY, KHAKH, MANJINDER, FLEMING, VICKI M, LISTER, MICHELLE M, HOWSON-WELLS, HANNAH C, HOLMES, EDWARD C, LOOSE, MATTHEW W, BALL, JONATHAN K, MCCLURE, C PATRICK and ON BEHALF OF THE COG-UK CONSORTIUM, 2021. Retrospective screening of routine respiratory samples revealed undetected community transmission and missed intervention opportunities for SARS-CoV-2 in the United Kingdom. The Journal of general virology. 102(6),
  • URBANOWICZ, RICHARD A, TSOLERIDIS, THEOCHARIS, JACKSON, HANNAH J, CUSIN, LOLA, DUNCAN, JOSHUA D, CHAPPELL, JOSEPH G, TARR, ALEXANDER W, NIGHTINGALE, JESSICA, NORRISH, ALAN R, IKRAM, ADEEL, MARSON, BEN, CRAXFORD, SIMON J, KELLY, ANTHONY, AITHAL, GURUPRASAD P, VIJAY, AMRITA, TIGHE, PATRICK J, BALL, JONATHAN K, VALDES, ANA M and OLLIVERE, BENJAMIN J, 2021. Two doses of the SARS-CoV-2 BNT162b2 vaccine enhances antibody responses to variants in individuals with prior SARS-CoV-2 infection. Science translational medicine.
  • FRANCIS, RODRIC V, BILLAM, HARRIET, CLARKE, MITCH, YATES, CARL, TSOLERIDIS, THEOCHARIS, BERRY, LOUISE, MAHIDA, NIKUNJ, IRVING, WILLIAM L, MOORE, CHRISTOPHER, HOLMES, NADINE, BALL, JONATHAN, LOOSE, MATTHEW and MCCLURE, C PATRICK, 2021. The impact of real-time whole genome sequencing in controlling healthcare-associated SARS-CoV-2 outbreaks. The Journal of infectious diseases.
  • TSOLERIDIS T, CHAPPELL JG, MONCHATRE-LEROY E, UMHANG G, SHI M, BENNETT M, TARLINTON RE, MCCLURE CP, HOLMES EC and BALL JK, 2020. Discovery and Prevalence of Divergent RNA Viruses in European Field Voles and Rabbits. Viruses. 12(1),
  • CHAPPELL, J.G., TSOLERIDIS, T., ONIANWA, O., DRAKE, G., ASHPOLE, I., DOBBS, P., EDEMA, W., KUMI-ANSAH, F., BENNETT, M., TARLINTON, R.E., BALL, J.K. and MCCLURE, C.P., 2020. Retrieval of the Complete Coding Sequence of the UK-Endemic Tatenale Orthohantavirus Reveals Extensive Strain Variation and Supports Its Classification as a Novel Species Viruses. 12, 454
  • BLOK, ANDREW J, GURNANI, PRATIK, XENOPOULOS, ALEX, BURROUGHS, LAURENCE, DUNCAN, JOSHUA, URBANOWICZ, RICHARD A, TSOLERIDIS, THEOCHARIS, MULLER-KRAUTER, HELENA, STRECKER, THOMAS, BALL, JONATHAN K, ALEXANDER, CAMERON and ALEXANDER, MORGAN R, 2020. Polymer microarrays rapidly identify competitive adsorbents of virus-like particles. Biointerphases. 15(6), 061005
  • TSOLERIDIS, THEOCHARIS and BALL, JONATHAN K, 2020. Discovery of Novel Coronaviruses in Rodents. Methods in molecular biology (Clifton, N.J.). 2203, 33-40
  • ALM, ERIK, BROBERG, EEVA K., CONNOR, THOMAS, HODCROFT, EMMA B., KOMISSAROV, ANDREY B., MAURER-STROH, SEBASTIAN, MELIDOU, ANGELIKI, NEHER, RICHARD A., O'TOOLE, AINE and PEREYASLOV, DMITRIY, 2020. Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020 EUROSURVEILLANCE. 25(32), 7-14
  • AANENSEN, DAVID M.; ABUDAHAB, KHALIL; ADAMS, ALEXANDER; AFIFI, SAFIAH; ALAM, MOHAMMED T.; ET AL. LANCET MICROBE, 2020. An integrated national scale SARS-CoV-2 genomic surveillance network 1(3),
  • TSOLERIDIS, T, CHAPPELL, J, ONIANWA, O, MARSTON, D A, FOOKS, A R, MONCHATRE-LEROY, E, UMHANG, G, MULLER, M M, DREXLER, J F, DROSTEN, C, TARLINTON, R E, MCCLURE, C P, HOLMES, E C and BALL, J K, 2019. Shared common ancestry of alphacoronaviruses in globally distributed rodents Viruses. 11(2), 125
  • CHAPPELL JG, BYARUHANGA T, TSOLERIDIS T, BALL JK and MCCLURE CP, 2019. Identification of Infectious Agents in High-Throughput Sequencing Data Sets Is Easily Achievable Using Free, Cloud-Based Bioinformatics Platforms. Journal of clinical microbiology. 57(12),
  • TSOLERIDIS T, ONIANWA O, HORNCASTLE E, DAYMAN E, ZHU M, DANJITTRONG T, WACHTL M, BEHNKE JM, CHAPMAN S, STRONG V, DOBBS P, BALL JK, TARLINTON RE and MCCLURE CP, 2016. Discovery of Novel Alphacoronaviruses in European Rodents and Shrews. Viruses. 8(3), 84
  • URBANOWICZ RA, MCCLURE CP, BROWN RJ, TSOLERIDIS T, PERSSON MA, KREY T, IRVING WL, BALL JK and TARR AW, 2015. A Diverse Panel of Hepatitis C Virus Glycoproteins for Use in Vaccine Research Reveals Extremes of Monoclonal Antibody Neutralization Resistance. Journal of virology. 90(7), 3288-301

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