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Theocharis Tsoleridis

Research Fellow, Faculty of Medicine & Health Sciences

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Biography

I studied Molecular Biology & Genetics at the Democritus University of Thrace, Greece from 2006 to 2010. I obtained my MSc in Molecular Genetics & Diagnostics at the University of Nottingham, UK in 2012. In 2018 I have completed my PhD in Molecular Virology at the University of Nottingham with a full scholarship from BBSRC DTP studying emerging coronaviruses in rodents. I have also worked at the Eberhard Karl University of Tübingen, Germany in 2010 and at the Institute of Virology in Bonn, Germany in 2016 as a visiting scientist.

Since 2018 I have been working as a Research Fellow at the University of Nottingham with Prof Jonathan Ball. I am currently involved in several research projects including virus discovery and evolution, viral entry, molecular epidemiology and cow monoclonal antibodies.

Expertise Summary

My research expertise is focused in three areas: Virus Discovery & Evolution, Viral entry & tropism, Cow monoclonal antibodies.

Virus Discovery & Evolution

We are involved in projects in which we collect animal tissues (mainly rodents) and screen them either with PCR or NGS to discover new viruses. We then try to acquire their full genome and perform phylogenetic analyses to understand their origin and evolution, extending our knowledge of wildlife reservoirs. We currently have active collaborations within the UK, Europe and Central/South America.

We have discovered novel rodent Alphacoronaviruses in Europe ( https://doi.org/10.3390/v8030084 ) that shared a common ancestry with other rodent Alphacoronaviruses from around the world ( https://doi.org/10.3390/v11020125 ). We have also discovered several novel viruses including astroviruses, paramyxoviruses ( https://doi.org/10.3390/v12010047 ) and hantaviruses ( https://doi.org/10.3390/v12040454 ).

Viral entry and tropism

We use a pseudotyping system to generate pseudotypes of enveloped viruses and assess their entry into cells. We have managed to pseudotype several viruses including Hepatitis C (https://jvi.asm.org/content/90/7/3288) , SARS-CoV, SARS-CoV-2, MERS-CoV and Lassa Fever Virus.

We are also involved in projects testing the efficacy of COVID-19 vaccine candidates using pseudotype SARS-CoV-2 neutralisation assays (https://doi.org/10.1016/j.ymthe.2021.04.022).

Selected Publications

  • CAPONE, STEFANIA, RAGGIOLI, ANGELO, GENTILE, MICHELA, BATTELLA, SIMONE, LAHM, ARMIN, SOMMELLA, ANDREA, CONTINO, ALESSANDRA MARIA, URBANOWICZ, RICHARD A, SCALA, ROMINA, BARRA, FEDERICA, LEUZZI, ADRIANO, LILLI, ELEONORA, MISELLI, GIUSEPPINA, NOTO, ALESSIA, FERRAIUOLO, MARIA, TALOTTA, FRANCESCO, TSOLERIDIS, THEOCHARIS, CASTILLETTI, CONCETTA, MATUSALI, GIULIA, COLAVITA, FRANCESCA, LAPA, DANIELE, MESCHI, SILVIA, CAPOBIANCHI, MARIA, SORIANI, MARCO, FOLGORI, ANTONELLA, BALL, JONATHAN K, COLLOCA, STEFANO and VITELLI, ALESSANDRA, 2021. Immunogenicity of a new gorilla adenovirus vaccine candidate for COVID-19. Molecular therapy : the journal of the American Society of Gene Therapy.
  • TSOLERIDIS T, CHAPPELL JG, MONCHATRE-LEROY E, UMHANG G, SHI M, BENNETT M, TARLINTON RE, MCCLURE CP, HOLMES EC and BALL JK, 2020. Discovery and Prevalence of Divergent RNA Viruses in European Field Voles and Rabbits. Viruses. 12(1),
  • TSOLERIDIS, THEOCHARIS and BALL, JONATHAN K, 2020. Discovery of Novel Coronaviruses in Rodents. Methods in molecular biology (Clifton, N.J.). 2203, 33-40
  • TSOLERIDIS, T, CHAPPELL, J, ONIANWA, O, MARSTON, D A, FOOKS, A R, MONCHATRE-LEROY, E, UMHANG, G, MULLER, M M, DREXLER, J F, DROSTEN, C, TARLINTON, R E, MCCLURE, C P, HOLMES, E C and BALL, J K, 2019. Shared common ancestry of alphacoronaviruses in globally distributed rodents Viruses. 11(2), 125

School of Life Sciences

University of Nottingham
Medical School
Queen's Medical Centre
Nottingham NG7 2UH

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