Contact

• workRoom West Block, C Floor Tumour Vascular Biology Group
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 8231142
• Andrew.Benest@nottingham.ac.uk
• http://www.tvbl-nottingham.org/benest.html

Biography

After studying Physiology (at the University of Bristol) for both degree (2003) and PhD (2006) I learnt the importance of in vivo studies (with Prof David Bates). I first moved to Freiberg (south west Germany) and then followed the group to the DKFZ in Heidelberg, where i learnt how to study endothelial cell biology, in the context of angiogenesis and inflammation with Prof Hellmut Augustin. Moving to Leeds I struggled with GTPase biology in endothelial cells, but was able to contribute to exploring how NK cells regulate endothelial cell phenotypes during inflammation. This led to my next move to Nottingham, where i have worked on several projects involving endothelial cell biolgy and sensing the local environment; shear stress, growth factors, and inflammation. This resulted in my research area today of how the local endothelial microenvironment determines transcriptional changes in the endothelial cell and how this regulates its phenotype. I currently have projects involving transcription factors, hypoxia and extracellular matrix composition and in particular how this is important in eye disease.

Expertise Summary

Endothelial cells

Angiogenesis

Cytokines

Transcription factors

Teaching Summary

I will be the Convenor of the "Hallmarks of Cancer" module in the forthcoming BSc and MSci Cancer Sciences courses

I contribute to the BMedSci course and also MSci in Neuroscience

Research Summary

Angiogenesis

Endothelial cell biology

Recent Publications

• BEAZLEY-LONG N, MOSS CE, ASHBY WR, BESTALL SM, ALMAHASNEH F, DURRANT AM, BENEST AV, BLACKLEY Z, BALLMER-HOFER K, HIRASHIMA M, HULSE RP, BATES DO and DONALDSON LF, 2018. VEGFR2 promotes central endothelial activation and the spread of pain in inflammatory arthritis. Brain, behavior, and immunity.
• MORTARA L, BENEST AV, BATES DO and NOONAN DM, 2017. Can the co-dependence of the immune system and angiogenesis facilitate pharmacological targeting of tumours? Current opinion in pharmacology. 35, 66-74 (In Press.)
• BENEST AV and BATES DO, 2016. Measurement of Angiogenesis, Arteriolargenesis, and Lymphangiogenesis Phenotypes by Use of Two-Dimensional Mesenteric Angiogenesis Assay. Methods in molecular biology (Clifton, N.J.). 1430, 345-54
• SAVANT S, LA PORTA S, BUDNIK A, BUSCH K, HU J, TISCH N, KORN C, VALLS AF, BENEST AV, TERHARDT D, QU X, ADAMS RH, BALDWIN HS, RUIZ DE ALMODÓVAR C, RODEWALD HR and AUGUSTIN HG, 2015. The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells. Cell reports. 12(11), 1761-73

• View all publications

• BEAZLEY-LONG N, MOSS CE, ASHBY WR, BESTALL SM, ALMAHASNEH F, DURRANT AM, BENEST AV, BLACKLEY Z, BALLMER-HOFER K, HIRASHIMA M, HULSE RP, BATES DO and DONALDSON LF, 2018. VEGFR2 promotes central endothelial activation and the spread of pain in inflammatory arthritis. Brain, behavior, and immunity.
• MORTARA L, BENEST AV, BATES DO and NOONAN DM, 2017. Can the co-dependence of the immune system and angiogenesis facilitate pharmacological targeting of tumours? Current opinion in pharmacology. 35, 66-74 (In Press.)
• BENEST AV and BATES DO, 2016. Measurement of Angiogenesis, Arteriolargenesis, and Lymphangiogenesis Phenotypes by Use of Two-Dimensional Mesenteric Angiogenesis Assay. Methods in molecular biology (Clifton, N.J.). 1430, 345-54
• SAVANT S, LA PORTA S, BUDNIK A, BUSCH K, HU J, TISCH N, KORN C, VALLS AF, BENEST AV, TERHARDT D, QU X, ADAMS RH, BALDWIN HS, RUIZ DE ALMODÓVAR C, RODEWALD HR and AUGUSTIN HG, 2015. The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells. Cell reports. 12(11), 1761-73
• HOLMES TD, WILSON EB, BLACK EV, BENEST AV, VAZ C, TAN B, TANAVDE VM and COOK GP, 2014. Licensed human natural killer cells aid dendritic cell maturation via TNFSF14/LIGHT. Proceedings of the National Academy of Sciences of the United States of America. 111(52), E5688-96
• BENEST AV, KRUSE K, SAVANT S, THOMAS M, LAIB AM, LOOS EK, FIEDLER U and AUGUSTIN HG, 2013. Angiopoietin-2 is critical for cytokine-induced vascular leakage. PloS one. 8(8), e70459
• THOMAS M, FELCHT M, KRUSE K, KRETSCHMER S, DEPPERMANN C, BIESDORF A, ROHR K, BENEST AV, FIEDLER U and AUGUSTIN HG, 2010. Angiopoietin-2 stimulation of endothelial cells induces alphavbeta3 integrin internalization and degradation. The Journal of biological chemistry. 285(31), 23842-9
• STONE, O. A., RICHER, C., EMANUELI, C., VAN WEEL, V., QUAX, P. H., KATARE, R., KRAENKEL, N., CAMPAGNOLO, P., BARCELOS, L. S., SIRAGUSA, M., SALA-NEWBY, G. B., BALDESSARI, D., MIONE, M., VINCENT, M. P., BENEST, A. V., AL HAJ ZEN, A., GONZALEZ, J., BATES, D. O., ALHENC-GELAS, F. and MADEDDU, P., 2009. Critical role of tissue kallikrein in vessel formation and maturation: implications for therapeutic revascularization: Arterioscler Thromb Vasc Biol Arterioscler Thromb Vasc Biol. 29(5), 657-64
• BHANDARKAR SS, JACONI M, FRIED LE, BONNER MY, LEFKOVE B, GOVINDARAJAN B, PERRY BN, PARHAR R, MACKELFRESH J, SOHN A, STOUFFS M, KNAUS U, YANCOPOULOS G, REISS Y, BENEST AV, AUGUSTIN HG and ARBISER JL, 2009. Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice. The Journal of clinical investigation. 119(8), 2359-65
• BENEST AV and AUGUSTIN HG, 2009. Tension in the vasculature. Nature medicine. 15(6), 608-10
• BENEST AV and BATES DO, 2009. Measurement of angiogenic phenotype by use of two-dimensional mesenteric angiogenesis assay. Methods in molecular biology (Clifton, N.J.). 467, 251-70
• BENEST AV and AUGUSTIN HG, 2009. Cancer: Blood vessels kept quiet. Nature. 458(7234), 41-2
• STONE OA, RICHER C, EMANUELI C, VAN WEEL V, QUAX PHA, KATARE R, KRAENKEL N, CAMPAGNOLO P, BARCELOS LS, SIRAGUSA M, SALA-NEWBY GB, BALDESSARI D, MIONE M, VINCENT MP, BENEST AV, AL HAJ ZEN A, GONZALEZ J, BATES DO, ALHENC-GELAS F and MADEDDU P, 2009. Critical role of tissue kallikrein in vessel formation and maturation: implications for therapeutic revascularization. Arteriosclerosis, thrombosis, and vascular biology. 29(5), 657-64
• BENEST AV, STONE OA, MILLER WH, GLOVER CP, UNEY JB, BAKER AH, HARPER SJ and BATES DO, 2008. Arteriolar genesis and angiogenesis induced by endothelial nitric oxide synthase overexpression results in a mature vasculature. Arteriosclerosis, thrombosis, and vascular biology. 28(8), 1462-8
• BENEST AV, HARPER SJ, HERTTUALA SY, ALITALO K and BATES DO, 2008. VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis. Cardiovascular research. 78(2), 315-23
• CROSS SE, RICHARDS SK, CLARK A, BENEST AV, BATES DO, MATHIESON PW, JOHNSON PRV, HARPER SJ and SMITH RM, 2007. Vascular endothelial growth factor as a survival factor for human islets: effect of immunosuppressive drugs. Diabetologia. 50(7), 1423-32
• BENEST AV, SALMON AH, WANG W, GLOVER CP, UNEY J, HARPER SJ and BATES DO, 2006. VEGF and angiopoietin-1 stimulate different angiogenic phenotypes that combine to enhance functional neovascularization in adult tissue. Microcirculation (New York, N.Y. : 1994). 13(6), 423-37
• RIDLEY JM, MILNES JT, BENEST AV, MASTERS JD, WITCHEL HJ and HANCOX JC, 2003. Characterisation of recombinant HERG K+ channel blockade by the Class Ia antiarrhythmic drug procainamide. Biochemical and biophysical research communications. 306(2), 388-93