Contact

• workRoom West Block, C Floor Tumour Vascular Biology Group
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 8231548
• Andrew.Benest@nottingham.ac.uk

Research Summary

Angiogenesis

Endothelial cell biology

Recent Publications

• BENEST AV, KRUSE K, SAVANT S, THOMAS M, LAIB AM, LOOS EK, FIEDLER U and AUGUSTIN HG, 2013. Angiopoietin-2 is critical for cytokine-induced vascular leakage. PloS one. 8(8), e70459
• THOMAS M, FELCHT M, KRUSE K, KRETSCHMER S, DEPPERMANN C, BIESDORF A, ROHR K, BENEST AV, FIEDLER U and AUGUSTIN HG, 2010. Angiopoietin-2 stimulation of endothelial cells induces alphavbeta3 integrin internalization and degradation. The Journal of biological chemistry. 285(31), 23842-9
• STONE, O. A., RICHER, C., EMANUELI, C., VAN WEEL, V., QUAX, P. H., KATARE, R., KRAENKEL, N., CAMPAGNOLO, P., BARCELOS, L. S., SIRAGUSA, M., SALA-NEWBY, G. B., BALDESSARI, D., MIONE, M., VINCENT, M. P., BENEST, A. V., AL HAJ ZEN, A., GONZALEZ, J., BATES, D. O., ALHENC-GELAS, F. and MADEDDU, P., 2009. Critical role of tissue kallikrein in vessel formation and maturation: implications for therapeutic revascularization: Arterioscler Thromb Vasc Biol Arterioscler Thromb Vasc Biol. 29(5), 657-64
• BHANDARKAR SS, JACONI M, FRIED LE, BONNER MY, LEFKOVE B, GOVINDARAJAN B, PERRY BN, PARHAR R, MACKELFRESH J, SOHN A, STOUFFS M, KNAUS U, YANCOPOULOS G, REISS Y, BENEST AV, AUGUSTIN HG and ARBISER JL, 2009. Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice. The Journal of clinical investigation. 119(8), 2359-65

• View all publications

• BENEST AV, KRUSE K, SAVANT S, THOMAS M, LAIB AM, LOOS EK, FIEDLER U and AUGUSTIN HG, 2013. Angiopoietin-2 is critical for cytokine-induced vascular leakage. PloS one. 8(8), e70459
• THOMAS M, FELCHT M, KRUSE K, KRETSCHMER S, DEPPERMANN C, BIESDORF A, ROHR K, BENEST AV, FIEDLER U and AUGUSTIN HG, 2010. Angiopoietin-2 stimulation of endothelial cells induces alphavbeta3 integrin internalization and degradation. The Journal of biological chemistry. 285(31), 23842-9
• STONE, O. A., RICHER, C., EMANUELI, C., VAN WEEL, V., QUAX, P. H., KATARE, R., KRAENKEL, N., CAMPAGNOLO, P., BARCELOS, L. S., SIRAGUSA, M., SALA-NEWBY, G. B., BALDESSARI, D., MIONE, M., VINCENT, M. P., BENEST, A. V., AL HAJ ZEN, A., GONZALEZ, J., BATES, D. O., ALHENC-GELAS, F. and MADEDDU, P., 2009. Critical role of tissue kallikrein in vessel formation and maturation: implications for therapeutic revascularization: Arterioscler Thromb Vasc Biol Arterioscler Thromb Vasc Biol. 29(5), 657-64
• BHANDARKAR SS, JACONI M, FRIED LE, BONNER MY, LEFKOVE B, GOVINDARAJAN B, PERRY BN, PARHAR R, MACKELFRESH J, SOHN A, STOUFFS M, KNAUS U, YANCOPOULOS G, REISS Y, BENEST AV, AUGUSTIN HG and ARBISER JL, 2009. Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice. The Journal of clinical investigation. 119(8), 2359-65
• BENEST AV and AUGUSTIN HG, 2009. Tension in the vasculature. Nature medicine. 15(6), 608-10
• BENEST AV and BATES DO, 2009. Measurement of angiogenic phenotype by use of two-dimensional mesenteric angiogenesis assay. Methods in molecular biology (Clifton, N.J.). 467, 251-70
• BENEST AV and AUGUSTIN HG, 2009. Cancer: Blood vessels kept quiet. Nature. 458(7234), 41-2
• STONE OA, RICHER C, EMANUELI C, VAN WEEL V, QUAX PHA, KATARE R, KRAENKEL N, CAMPAGNOLO P, BARCELOS LS, SIRAGUSA M, SALA-NEWBY GB, BALDESSARI D, MIONE M, VINCENT MP, BENEST AV, AL HAJ ZEN A, GONZALEZ J, BATES DO, ALHENC-GELAS F and MADEDDU P, 2009. Critical role of tissue kallikrein in vessel formation and maturation: implications for therapeutic revascularization. Arteriosclerosis, thrombosis, and vascular biology. 29(5), 657-64
• BENEST AV, STONE OA, MILLER WH, GLOVER CP, UNEY JB, BAKER AH, HARPER SJ and BATES DO, 2008. Arteriolar genesis and angiogenesis induced by endothelial nitric oxide synthase overexpression results in a mature vasculature. Arteriosclerosis, thrombosis, and vascular biology. 28(8), 1462-8
• BENEST AV, HARPER SJ, HERTTUALA SY, ALITALO K and BATES DO, 2008. VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis. Cardiovascular research. 78(2), 315-23
• CROSS SE, RICHARDS SK, CLARK A, BENEST AV, BATES DO, MATHIESON PW, JOHNSON PRV, HARPER SJ and SMITH RM, 2007. Vascular endothelial growth factor as a survival factor for human islets: effect of immunosuppressive drugs. Diabetologia. 50(7), 1423-32
• BENEST AV, SALMON AH, WANG W, GLOVER CP, UNEY J, HARPER SJ and BATES DO, 2006. VEGF and angiopoietin-1 stimulate different angiogenic phenotypes that combine to enhance functional neovascularization in adult tissue. Microcirculation (New York, N.Y. : 1994). 13(6), 423-37
• RIDLEY JM, MILNES JT, BENEST AV, MASTERS JD, WITCHEL HJ and HANCOX JC, 2003. Characterisation of recombinant HERG K+ channel blockade by the Class Ia antiarrhythmic drug procainamide. Biochemical and biophysical research communications. 306(2), 388-93