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Alison Woodward

Research Fellow, Faculty of Medicine & Health Sciences

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Biography

During my Chemistry degree at the University of Durham, I developed an interest in analytical chemistry and sought a job in that area after graduating. I worked as a lab technician for a year at a company in Derbyshire where I was trained to use chromatographic instruments (HPLC-UV, HPLC-MS, HPLC-MS-MS and GC-FID). I thoroughly enjoyed this work. To further my practical skills and knowledge I chose to undertake postgraduate research at the University of Nottingham on a Biotechnology project that involved a large proportion of analytical work and also appealed to my love of sustainable technology. Following this I took a sabbatical and then started work in the Children's Brain Tumour Research Centre at the University of Nottingham (School of Medicine) where I am using a mass spectrometer with very high resolving power and accurate mass measurement (an Orbitrap) in the School of Pharmacy to conduct untargeted metabolomics of childhood ependymoma tumours. This work is really interesting and rewarding.

Expertise Summary

Analytical chemistry - specifically chromatography with MS and NMR spectroscopy.

Research Summary

Disrupting cancer metabolism to improve therapy for childhood ependymoma:

- Use liquid chromatography with mass spectrometry (LC-MS) to describe the childhood ependymoma metabolome.

- Identify which metabolic enzymes correlate to the abundant metabolites (and metabolic pathways).

Working with Dr Ruman Rahman in the School of Medicine.

Past Research

PhD thesis: The enzymatic depolymerisation of lignin model compounds. This involved incubating laccase with three lignin model oligomers for periods of up to 24 hours and analysing the product mixtures using HSQC (1H-13C) nuclear magnetic resonance (NMR) spectroscopy, gas chromatography with mass spectrometry (GC-MS) and gel permeation chromatography (GPC).

Working with Prof Gill Stephens in the Department of Chemical and Environmental Engineering.

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

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