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madhumita dandapani

Clinical Associate Professor of Paediatric Oncology/Neuro Oncology, Faculty of Medicine & Health Sciences

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Biography

I have been a Consultant Paediatric oncologist with clinical expertise in paediatric solid tumours and brain tumours in Nottingham since 2016 and was appointed as Clinical Associate Professor at the University of Nottingham in March 2019.

I completed my medical degree in India in 2002 and moved to the UK where i trained to become a paediatric oncologist. I obtained my PhD in 2012 in cancer cell signalling from the University of Dundee investigating the interplay between cellular metabolism and chemotherapy induced DNA damage. I have developed a research niche in tumour metabolism, particularly in childhood brain and liver tumours and lead a research group within the Children's Brain tumour research centre . I have written clinical trials including PHITT (Paediatric Hepatic International Tumour Trial) and I am co-Investigator on this study. I am a member of the SIOPEL (International Society of Paediatric Oncology Liver group) and on the SIOP Scientific Advisory board for liver tumours. I am the NIHR CRN lead for Paediatric Oncology in the East Midlands and Principal Investigator on several clinical trials. My career aim is to develop novel therapies for children with cancer and to improve outcomes for children with cancer in developing countries.

Teaching Summary

Lead for Undegraduate paediatrics - BMBS course

Interim FiY1 lead May-Aug 2020

MSc Oncology supervisor since 2018

MSc CIB supervisor since 2019

Open to self funding PhDs

Research Summary

Brain tumours

CCLG Little Princess Project Grant -£96,445- Aug 2019- July 2021. Exploring alterations in amino acid metabolism as novel therapeutic targets in paediatric glial tumours using advanced metabolomics methods

University Of Nottingham International collaboration fund- £ 5000- Jan 2020- Dec 2020- Promoting early diagnosis of brain tumours children in South India

Using CSF Biomarkers to detect minimal residual disease in ependymoma

Liver tumours

Co-investigator of the international PHITT study with Professor Morland, Birmingham

Investigating the metabolome of hepatoblastoma- collaboration with Carolina Armengol, Spain

International hepatoblastoma relapse registry-UK lead

Early diagnosis

Promoting early diagnosis of brain tumours in India

Past Research

Investigating the arginine auxotrophy of childhood brain tumours

Investigating the AMPK pathway in cancer and DNA damage

Future Research

Plans to expand metabolomics based research in low grade glioma and medulloblastoma

Translational projects using metabolomic approaches to effect suppression of tumour growth and recurrence.

Improving early diagnosis of abdominal tumours in the UK

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

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