Contact

• workRoom Room 3011 Medical School
  Royal Derby Hospital
  Uttoxeter Road
  Derby
  DE22 3DT
  UK
• work01332 724688
• Mathew.Piasecki@nottingham.ac.uk

Biography

My research focus is the age-related remodelling of skeletal muscle motor units; the reduction in motor unit number and corresponding expansion of motor unit size/innervation ratio. Occurring via repeated cycles of fibre denervation and reinnervation, it is evident this compensatory mechanism of axonal sprouting is not always successful and may be influenced by activity levels, thus highlighting the plasticity of the peripheral neuromuscular system. To date these investigations have involved intramuscular EMG at the single motor unit/muscle fibre level combined with in/voluntary contractions, with current work also involving alterations in gene expression and immunohistochemistry data. Among the aims here is to establish imaging biomarkers of age-related neuromuscular dysfunction and associate them with clinically relevant functional outcomes.

Teaching Summary

I teach on a variety of topics on both the Graduate Entry Medical Course and the BSc in Medical Physiology and Therapeutics.

Recent Publications

• ELLWOOD, REBECCA A, SLADE, LUKE, LEWIS, JONATHAN, TORREGROSSA, ROBERTA, SUDEVAN, SURABHI, PIASECKI, MATHEW, WHITEMAN, MATTHEW, ETHERIDGE, TIMOTHY and SZEWCZYK, NATHANIEL J, 2022. Sulfur amino acid supplementation displays therapeutic potential in a C. elegans model of Duchenne muscular dystrophy. Communications biology. 5(1), 1255
• HARDY, EDWARD J., HATT, JACOB, DOLEMAN, BRETT, SMART, THOMAS F., PIASECKI, MATTHEW, LUND, JONATHAN N. and PHILLIPS, BETHAN E., 2022. Post-operative electrical muscle stimulation attenuates loss of muscle mass and function following major abdominal surgery in older adults: a split body randomised control trial AGE AND AGEING. 51(10),
• GUO, Y., JONES, E. J., INNS, T. B., PHILLIPS, B. E., ATHERTON, P. J. and PIASECKI, M., 2022. Reduced amplitude of persistent inward currents in the aged human vastus lateralis ACTA PHYSIOLOGICA. 236, 357-359
• JONES, E. J., GUO, Y., ATHERTON, P., PHILLIPS, B. E. and PIASECKI, M., 2022. Motor unit firing rate variability and microvascular blood flow as mediators of neuromuscular control. ACTA PHYSIOLOGICA. 236, 142-143

• View all publications

• ELLWOOD, REBECCA A, SLADE, LUKE, LEWIS, JONATHAN, TORREGROSSA, ROBERTA, SUDEVAN, SURABHI, PIASECKI, MATHEW, WHITEMAN, MATTHEW, ETHERIDGE, TIMOTHY and SZEWCZYK, NATHANIEL J, 2022. Sulfur amino acid supplementation displays therapeutic potential in a C. elegans model of Duchenne muscular dystrophy. Communications biology. 5(1), 1255
• HARDY, EDWARD J., HATT, JACOB, DOLEMAN, BRETT, SMART, THOMAS F., PIASECKI, MATTHEW, LUND, JONATHAN N. and PHILLIPS, BETHAN E., 2022. Post-operative electrical muscle stimulation attenuates loss of muscle mass and function following major abdominal surgery in older adults: a split body randomised control trial AGE AND AGEING. 51(10),
• GUO, Y., JONES, E. J., INNS, T. B., PHILLIPS, B. E., ATHERTON, P. J. and PIASECKI, M., 2022. Reduced amplitude of persistent inward currents in the aged human vastus lateralis ACTA PHYSIOLOGICA. 236, 357-359
• JONES, E. J., GUO, Y., ATHERTON, P., PHILLIPS, B. E. and PIASECKI, M., 2022. Motor unit firing rate variability and microvascular blood flow as mediators of neuromuscular control. ACTA PHYSIOLOGICA. 236, 142-143
• GHARAHDAGHI, N., GUO, Y., RUDRAPPA, S., PHILLIPS, B. E., IDRIS, I., WILKINSON, D. J., SZEWCZYK, N. J., SMITH, K., PIASECKI, M. and ATHERTON, P. J., 2022. Distinct gene expression signatures of the aged human neuromuscular junction ACTA PHYSIOLOGICA. 236, 133-133
• BOLLEN, S. E., BASS, J. J., CROSSLAND, H., PIASECKI, J., MCPHEE, J. S., PIASECKI, M., WILKINSON, D. J., HEWISON, M. and ATHERTON, P. J., 2022. The association of vitamin D binding protein gene (GC) single nucleotide polymorphisms with skeletal muscle function and performance in master athletes. ACTA PHYSIOLOGICA. 236, 365-367
• INNS, THOMAS B., BASS, JOSEPH J., HARDY, EDWARD J. O., WILKINSON, DANIEL J., STASHUK, DANIEL W., ATHERTON, PHILIP J., PHILLIPS, BETHAN E. and PIASECKI, MATHEW, 2022. Motor unit dysregulation following 15 days of unilateral lower limb immobilisation JOURNAL OF PHYSIOLOGY-LONDON. 600(21), 4753-4769
• ELY, ISABEL A., JONES, ELEANOR J., INNS, THOMAS B., DOOLEY, SIOBHRA, MILLER, SARAH B. J., STASHUK, DANIEL W., ATHERTON, PHILIP J., PHILLIPS, BETHAN E. and PIASECKI, MATHEW, 2022. Training-induced improvements in knee extensor force accuracy are associated with reduced vastus lateralis motor unit firing variability EXPERIMENTAL PHYSIOLOGY. 107(9), 1061-1070
• GUO, YUXIAO, PIASECKI, JESSICA, SWIECICKA, AGNIESZKA, IRELAND, ALEX, PHILLIPS, BETHAN E., ATHERTON, PHILIP J., STASHUK, DANIEL, RUTTER, MARTIN K., MCPHEE, JAMIE S. and PIASECKI, MATHEW, 2022. Circulating testosterone and dehydroepiandrosterone are associated with individual motor unit features in untrained and highly active older men GEROSCIENCE. 44(3), 1215-1228
• SMART TFF, DOLEMAN B, HATT J, PAUL M, TOFT S, LUND JN and PHILLIPS BE, 2022. The role of resistance exercise training for improving cardiorespiratory fitness in healthy older adults: a systematic review and meta-analysis Age Ageing. 51(6), afac143
• GUO Y, JONES EJ, INNS TB, ELY IA, STASHUK DW, WILKINSON DJ, SMITH K, PIASECKI J, PHILLIPS BE, ATHERTON PJ and PIASECKI M, 2022. Neuromuscular recruitment strategies of the vastus lateralis according to sex Acta Physiol (Oxf). 235(2), e13803
• JONES EJ, CHIOU SY, ATHERTON PJ, PHILLIPS BE and PIASECKI M, 2022. Ageing and exercise induced motor unit remodelling J Physiol. 600(8), 1839-1849
• GLADMAN JFR, PIASECKI M, CHADBORN N and FROST K, 2022. NIHR Nottingham Biomedical Research Centre (BRC) Musculoskeletal theme: virtual conference proceedings In: BRC MSK Conference.
• INNS, THOMAS, BASS, JOSEPH, HARDY, EDWARD, STASHUK, DANIEL, ATHERTON, PHILIP, PHILLIPS, BETHAN and PIASECKI, MATHEW, 2021. The impact of quadriceps disuse atrophy on motor unit properties FASEB JOURNAL. 35,
• GUO, YUXIAO, PIASECKI, JESSICA, SWIECICKA, AGNIESZKA, IRELAND, ALEX, PHILLIPS, BETHAN, ATHERTON, PHILIP, STASHUK, DANIEL, RUTTER, MARTIN, MCPHEE, JAMIE and PIASECKI, MATHEW, 2021. Circulating Dehydroepiandrosterone and Testosterone are Differentially Associated with Motor Unit Function in Young and Masters Athletes FASEB JOURNAL. 35,
• JONES, ELEANOR, MARTINEZ-VALDES, EDUARDO, NEGRO, FRANCESCO, MCCORMICK, DANIEL, ATHERTON, PHILIP, PHILLIPS, BETHAN and PIASECKI, MATHEW, 2021. Tracking of Individual Motor Units Following Concentric and Eccentric Exercise-induced Fatigue Reveals Contraction-type Specific Changes in Discharge Properties FASEB JOURNAL. 35,
• CROSSLAND, HANNAH, PIASECKI, JESSICA, MCCORMICK, DANIEL, PHILLIPS, BETHAN E., WILKINSON, DANIEL J., SMITH, KENNETH, MCPHEE, JAMIE S., PIASECKI, MATHEW and ATHERTON, PHILIP J., 2020. Targeted genotype analyses of GWAS-derived lean body mass and handgrip strength-associated single-nucleotide polymorphisms in elite master athletes AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 319(2), R184-R194
• MESSA, GUY A. M., PIASECKI, MATHEW, RITTWEGER, JOERN, MCPHEE, JAMIE S., KOLTAI, ERIKA, RADAK, ZSOLT, SIMUNIC, BOSTJAN, HEINONEN, ARI, SUOMINEN, HARRI, KORHONEN, MARKO T. and DEGENS, HANS, 2020. Absence of an aging-related increase in fiber type grouping in athletes and non-athletes SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS.
• SWIECICKA, AGNIESZKA, PIASECKI, MATHEW, STASHUK, DANIEL, JONES, DAVID, WU, FREDERICK, MCPHEE, JAMIE S. and RUTTER, MARTIN K., 2020. Relationship of Anabolic Hormones With Motor Unit Characteristics in Quadriceps Muscle in Healthy and Frail Aging Men JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 105(7), E2358-E2368
• MESSA, GUY A. M., PIASECKI, MATHEW, HURST, JOSH, HILL, CAMERON, TALLIS, JASON and DEGENS, HANS, 2020. The impact of a high-fat diet in mice is dependent on duration and age, and differs between muscles JOURNAL OF EXPERIMENTAL BIOLOGY. 223(6),
• PIASECKI, JESSICA, INNS, THOMAS B, BASS, JOSEPH J, SCOTT, REECE, STASHUK, DANIEL W, PHILLIPS, BETHAN E, ATHERTON, PHILIP J and PIASECKI, MATHEW, 2020. Influence of sex on the age-related adaptations of neuromuscular function and motor unit properties in elite masters athletes. The Journal of physiology.
• GUO Y, PHILLIPS BE, ATHERTON PJ and PIASECKI M, 2020. Molecular and Neural Adaptations to Neuromuscular Electrical Stimulation; Implications for Ageing Muscle Mech Ageing Dev. 193, 111402
• SWIECICKA, AGNIESZKA, PIASECKI, MATHEW, STASHUK, DANIEL W, IRELAND, ALEX, JONES, DAVID A, RUTTER, MARTIN K and MCPHEE, JAMIE S, 2019. Frailty phenotype and frailty index are associated with distinct neuromuscular electrophysiological characteristics in men. Experimental physiology.
• PIASECKI, M., IRELAND, A., PIASECKI, J., DEGENS, H., STASHUK, D. W., SWIECICKA, A., RUTTER, M. K., JONES, D. A. and MCPHEE, J. S., 2019. Long-Term Endurance and Power Training May Facilitate Motor Unit Size Expansion to Compensate for Declining Motor Unit Numbers in Older Age FRONTIERS IN PHYSIOLOGY. 10,
• AL-DABBAGH, SARAH, MCPHEE, JAMIE S., PIASECKI, MATHEW, STEWART, CLAIRE E. and AL-SHANTI, NASSER, 2019. Soluble Factors Released From Activated T Lymphocytes Regulate C2C12 Myoblast Proliferation and Cellular Signaling, but Effects Are Blunted in the Elderly JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 74(9), 1375-1385
• MESSA, G. A. M., PIASECKI, M., HILL, C., MCPHEE, J. S., TALLIS, J. and DEGENS, H., 2019. Morphological alterations of mouse skeletal muscles during early ageing are muscle specific EXPERIMENTAL GERONTOLOGY. 125,
• PIASECKI M, IRELAND A, PIASECKI J, STASHUK DW, SWIECICKA A, RUTTER MK, JONES DA and MCPHEE JS, 2018. Failure to expand the motor unit size to compensate for declining motor unit numbers distinguishes sarcopenic from non-sarcopenic older men. The Journal of physiology.
• PIASECKI M, IRELAND A, PIASECKI J, STASHUK DW, MCPHEE JS and JONES DA, 2018. The reliability of methods to estimate the number and size of human motor units and their use with large limb muscles. European journal of applied physiology. 118(4), 767-775
• MCPHEE JS, CAMERON J, MADEN-WILKINSON T, PIASECKI M, YAP MH, JONES DA and DEGENS H, 2018. The contributions of fibre atrophy, fibre loss, in situ specific force and voluntary activation to weakness in sarcopenia. The journals of gerontology. Series A, Biological sciences and medical sciences. (In Press.)
• PIASECKI J, IRELAND A, PIASECKI M, CAMERON J, MCPHEE JS and DEGENS H, 2018. The strength of weight-bearing bones is similar in amenorrheic and eumenorrheic elite long-distance runners. Scandinavian journal of medicine & science in sports. 28(5), 1559-1568
• YEUNG, SUEY S. Y., REIJNIERSE, ESMEE M., TRAPPENBURG, MARIJKE C., HOGREL, JEAN-YVES, MCPHEE, JAMIE S., PIASECKI, MATHEW, SIPILA, SARIANNA, SALPAKOSKI, ANU, BUTLER-BROWNE, GILLIAN, PAASUKE, MATI, GAPEYEVA, HELENA, NARICI, MARCO, V, MESKERS, CAREL G. M. and MAIER, ANDREA B., 2018. Handgrip Strength Cannot Be Assumed a Proxy for Overall Muscle Strength JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. 19(8), 703-709
• PIASECKI, J., MCPHEE, J. S., HANNAM, K., DEERE, K. C., ELHAKEEM, A., PIASECKI, M., DEGENS, H., TOBIAS, J. H. and IRELAND, A., 2018. Hip and spine bone mineral density are greater in master sprinters, but not endurance runners compared with non-athletic controls ARCHIVES OF OSTEOPOROSIS. 13(1),
• WILKINSON DJ, PIASECKI M and ATHERTON PJ, 2018. The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans Ageing Res Rev. 47, 123-132
• AL-DABBAGH S, MCPHEE JS, PIASECKI M, STEWART CE and AL-SHANTI N, 2018. Soluble factors released from activated T-lymphocytes regulate C2C12 myoblast proliferation and cellular signalling, but effects are blunted in the elderly. The journals of gerontology. Series A, Biological sciences and medical sciences. (In Press.)
• FRANCIS P, LYONS M, PIASECKI M, MC PHEE J, HIND K and JAKEMAN P, 2017. Measurement of muscle health in aging. Biogerontology. 18(6), 901-911
• PANNÉREC A, SPRINGER M, MIGLIAVACCA E, IRELAND A, PIASECKI M, KARAZ S, JACOT G, MÉTAIRON S, DANENBERG E, RAYMOND F, DESCOMBES P, MCPHEE JS and FEIGE JN, 2016. A robust neuromuscular system protects rat and human skeletal muscle from sarcopenia. Aging. 8(4), 712-29
• LEIGHTLEY D, YAP MH, COULSON J, PIASECKI M, CAMERON J, BARNOUIN Y, TOBIAS J and MCPHEE JS, 2016. Postural Stability During Standing Balance and Sit-to-Stand in Master Athlete Runners Compared With Nonathletic Old and Young Adults. Journal of aging and physical activity. 25(3), 345-350
• PIASECKI M, IRELAND A, COULSON J, STASHUK DW, HAMILTON-WRIGHT A, SWIECICKA A, RUTTER MK, MCPHEE JS and JONES DA, 2016. Motor unit number estimates and neuromuscular transmission in the tibialis anterior of master athletes: evidence that athletic older people are not spared from age-related motor unit remodeling. Physiological reports. 4(19),
• BAGLEY, LIAM, SLEVIN, MARK, BRADBURN, STEVEN, LIU, DONGHUI, MURGATROYD, CHRIS, MORRISSEY, GEORGE, CARROLL, MICHAEL, PIASECKI, MATHEW, GILMORE, WILLIAM S and MCPHEE, JAMIE S, 2016. 2max during exercise. BMJ open sport & exercise medicine. 2(1), e000056
• PIASECKI M, IRELAND A, STASHUK D, HAMILTON-WRIGHT A, JONES DA and MCPHEE JS, 2015. Age-related neuromuscular changes affecting human vastus lateralis. The Journal of physiology. 594(16), 4525-36
• PIASECKI M, IRELAND A, JONES DA and MCPHEE JS, 2015. Age-dependent motor unit remodelling in human limb muscles. Biogerontology. 17(3), 485-96
• VERLAAN S, ASPRAY TJ, BAUER JM, CEDERHOLM T, HEMSWORTH J, HILL TR, MCPHEE JS, PIASECKI M, SEAL C, SIEBER CC, TER BORG S, WIJERS SL and BRANDT K, 2015. Nutritional status, body composition, and quality of life in community-dwelling sarcopenic and non-sarcopenic older adults: A case-control study. Clinical nutrition (Edinburgh, Scotland). 36(1), 267-274