Contact

• workRoom E209 Biodiscovery Institute 3
  University Park
  Nottingham
  NG7 2RD
  UK
• hester.franks@nottingham.ac.uk

Biography

Current University of Nottingham Anne Mclaren Research Fellow. Previous MRC Clinical Research Fellow, NIHR Academic Clinical Fellow and NIHR Academic Clinical Lecturer

Research Summary

Cancer Immunotherapy, macrophages, adenosine pathways, immunotherapy toxicity, melanoma

Involved in clinical trials of melanoma treatments via clinical work for Nottingham University Hospitals NHS Trust.

Recent Publications

• F PATERA, SJ MISTRY, ND KINDON, E COMEO, J GOULDING, B KELLAM, LE KILPATRICK, H FRANKS and SJ HILL, 2024. A novel and selective fluorescent ligand for the study of adenosine A2B receptors Pharmacology Research & Perspectives.
• COCKING, DANIEL, DAMION, ROBIN, FRANKS, HESTER, JACONELLI, MATTHEW, WILKINSON, DANIEL, BROOK, MATTHEW, AUER, DOROTHEE and BOWTELL, RICHARD, 2023. Deuterium imaging at 7T during D2O dosing Magnetic Resonance in Medicine. 89(4), 1514-1521
• E ATALLAH, SJ WELSH, B O'CARRIGAN, A OSHAUGHNESSY, I DOLAPO, AS KERR, J KUCHARCZAK, CYC LEE, C CROOKS, A HICKS, CR CHIMAKURTHI, A RAO, H FRANKS, PM PATEL and GP AITHAL, 2023. Incidence, risk factors and outcomes of checkpoint inhibitor-induced liver injury: A 10-year real-world retrospective cohort study JHEP Reports.
• E BARNES, G HILLIER-MOSES, H MURRAY, C STEVINSON, HA FRANKS and L GOSSAGE, 2023. Evaluation of the MOVE online exercise programme for young people aged 13–30 Supportive Care in Cancer.

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• F PATERA, SJ MISTRY, ND KINDON, E COMEO, J GOULDING, B KELLAM, LE KILPATRICK, H FRANKS and SJ HILL, 2024. A novel and selective fluorescent ligand for the study of adenosine A2B receptors Pharmacology Research & Perspectives.
• COCKING, DANIEL, DAMION, ROBIN, FRANKS, HESTER, JACONELLI, MATTHEW, WILKINSON, DANIEL, BROOK, MATTHEW, AUER, DOROTHEE and BOWTELL, RICHARD, 2023. Deuterium imaging at 7T during D2O dosing Magnetic Resonance in Medicine. 89(4), 1514-1521
• E ATALLAH, SJ WELSH, B O'CARRIGAN, A OSHAUGHNESSY, I DOLAPO, AS KERR, J KUCHARCZAK, CYC LEE, C CROOKS, A HICKS, CR CHIMAKURTHI, A RAO, H FRANKS, PM PATEL and GP AITHAL, 2023. Incidence, risk factors and outcomes of checkpoint inhibitor-induced liver injury: A 10-year real-world retrospective cohort study JHEP Reports.
• E BARNES, G HILLIER-MOSES, H MURRAY, C STEVINSON, HA FRANKS and L GOSSAGE, 2023. Evaluation of the MOVE online exercise programme for young people aged 13–30 Supportive Care in Cancer.
• STODDART, LEIGH A., KINDON, NICHOLAS D., OTUN, OMOLADE, HARWOOD, CLARE R., PATERA, FOTEINI, VEPRINTSEV, DMITRY B., WOOLARD, JEANETTE, BRIDDON, STEPHEN J., FRANKS, HESTER A., HILL, STEPHEN J. and KELLAM, BARRIE, 2020. Ligand-directed covalent labelling of a GPCR with a fluorescent tag in live cells COMMUNICATIONS BIOLOGY. 3(1),
• ADHIKAREE, JASON, FRANKS, HESTER ANN, TELEVANTOS, CONSTANTINOS, VAGHELA, POONAM, KAUR, AANCHAL PREET, WALKER, DAVID, SCHMITZ, MARC, JACKSON, ANDREW MARK and PATEL, POULAM MANUBHAI, 2019. Impaired circulating myeloid CD1c+dendritic cell function in human glioblastoma is restored by p38 inhibition - implications for the next generation of DC vaccines ONCOIMMUNOLOGY. 8(7),
• MALECKA A, WANG Q, SHAH S, SUTAVANI R, SPENDLOVE I, RAMAGE J, GREENSMITH J, FRANKS H, GOUGH MJ, SAALBACH A, PATEL PM and JACKSON AM, 2016. Stromal fibroblasts support dendritic cells to maintain IL-23/Th17 responses after exposure to ionizing radiation. Journal of leukocyte biology. 100(2), 381-389
• LANGOSCH, S., WEHNER, R., MALECKA, A., FRANKS, H.A., SCHÄKEL, K., BACHMANN, M., JACKSON, A.M. and SCHMITZ, M., 2015. Impact of p38 mitogen-activated protein kinase inhibition on immunostimulatory properties of human 6-sulfo LacNAc dendritic cells Immunobiology.
• FRANKS, H.A., WANG, Q., LAX, S.J., COLLINS, M.K., ESCORS, D., PATEL, P.M. and JACKSON, A.M., 2014. Novel function for the p38-MK2 signalling pathway in circulating CD1c+ (BDCA-1+) myeloid dendritic cells from healthy donors and advanced cancer patients: inhibition of p38 enhances IL-12 whilst suppressing IL-10 International Journal of Cancer. 134(3), 575-586
• WANG, Q., FRANKS, H.A., LAX, S.J., EL REFAEE, M., MALECKA, A., SHAH, S., SPENDLOVE, I., GOUGH, M.J., SEEDHOUSE, C., MADHUSUDAN, S., PATEL, P.M. and JACKSON, A.M., 2013. The ataxia telangiectasia mutated kinase pathway regulates IL-23 expression by human dendritic cells Journal of Immunology. 190(7), 3246-3255
• FRANKS HA, WANG Q and PATEL PM, 2012. New anticancer immunotherapies. Anticancer research. 32(7), 2439-53
• WANG, Q., FRANKS, H.A., PORTE, J., EL REFAAE, M., SHAH, S., CROOKS, J., PATEL, P.M. and JACKSON, A.M., 2011. Novel approach for interleukin-23 up-regulation in human dendritic cells and the impact on T helper type 17 generation Immunology. 134(1), 60-72
• JACKSON, AM, MULCAHY, LA, PORTE, J, FRANKS, HA, EL REFAEE, M, WANG, Q, SHAH, S, ZHU, X and PATEL, PM, 2010. Role of mitogen-activated protein kinase and PI3K pathways in the regulation of IL-12-family cytokines in dendritic cells and the generation of TH-responses European Cytokine Network. 21(4), 319-328
• ZHU, X., MULCAHY, L.A., MOHAMMED, R.A., LEE, A.H., FRANKS, H.A., KILPATRICK, L., YILMAZER, A., PAISH, E.C., ELLIS, I.O., PATEL, P.M. and JACKSON, A.M., 2008. IL-17 expression by breast-cancer-associated macrophages: IL-17 promotes invasiveness of breast cancer cell lines Breast Cancer Research. 10(6), R95
• HILL, M, MCLEOD, F, FRANKS, H, GORDON, B and DOLAN, G, 2005. Genetic analysis in FXI deficiency: six novel mutations and the use of a polymerase chain reaction-based test to define a whole gene deletion BRITISH JOURNAL OF HAEMATOLOGY. 129(6), 825-829