Contact
Research Summary
I am a Research Fellow within the Centre for Respiratory Research/ Nottingham BRC in Translational Medical Sciences.
My research is focused on the study of cellular and molecular pathology mechanisms underlying chronic lung diseases (including idiopathic pulmonary fibrosis, asthma, COPD) and viral infections. I also participate in studies evaluating computational image analysis to quantify fibrosis/cellularity, expression profiling and reverse phase proteomics quantifying biomarkers.
Expertise Summary
Isolation, culture and characterisation of a variety of primary cells from human and animal tissue;
Molecular genetics, tissue microarrays
RNAScope, Pyrosequencing
Image analysis, Immunohistochemistry, immunocytochemistry, immunofluorescence and histological staining
Western blotting and electrophoresis
Recent Publications
KARIRI, YOUSIF, TOSS, MICHAEL S., ALSALEEM, MANSOUR, ELSHARAWY, KHLOUD A., JOSEPH, CHITRA, MONGAN, NIGEL P., GREEN, ANDREW R. and RAKHA, EMAD A., 2022. Ubiquitin-conjugating enzyme 2C (UBE2C) is a poor prognostic biomarker in invasive breast cancer BREAST CANCER RESEARCH AND TREATMENT. JOSEPH, CHITRA and TATLER, AMANDA L., 2022. Pathobiology of Airway Remodeling in Asthma: The Emerging Role of Integrins JOURNAL OF ASTHMA AND ALLERGY. 15, 595-610 JOSEPH, CHITRA, ALSALEEM, MANSOUR A., TOSS, MICHAEL S., KARIRI, YOUSIF A., ALTHOBITI, MARYAM, ALSAEED, SAMI, ALJOHANI, ABRAR I., NARASIMHA, PAVAN L., MONGAN, NIGEL P., GREEN, ANDREW R. and RAKHA, EMAD A., 2021. The ITIM-Containing Receptor: Leukocyte-Associated Immunoglobulin-Like Receptor-1 (LAIR-1) Modulates Immune Response and Confers Poor Prognosis in Invasive Breast Carcinoma CANCERS. 13(1), KARIRI, YOUSIF A., ALSALEEM, MANSOUR, JOSEPH, CHITRA, ALSAEED, SAMI, ALJOHANI, ABRAR, SHIINO, SHO, MOHAMMED, OMAR J., TOSS, MICHAEL S., GREEN, ANDREW R. and RAKHA, EMAD A., 2021. The prognostic significance of interferon-stimulated gene 15 (ISG15) in invasive breast cancer BREAST CANCER RESEARCH AND TREATMENT. 185(2), 293-305