Contact

• workRoom A17 Applied Health Research Building, University Park
  University Park
  Nottingham
  NG7 2RD
  UK
• Clare.Upton@nottingham.ac.uk

Biography

Clare is a Senior Trial Manager (STM) and has worked in clinical trial research since 2013. Clare started her career working for a clinical research organisation during which she gained experience in the development of Investigational Medicinal Products (IMPs) and the management of phase I and II clinical trials in healthy and patient populations.

In 2019 Clare started working at the Nottingham Clinical Trials Unit and to date has managed a number of multi-centre phase III trials in a wide range of areas including oncology, obstetrics and gynecology, neonatal medicine, and viral infection (Covid-19).

Teaching Summary

Clare currently teaches the Approvals and Regulations session of a short course designed and delivered by the Nottingham Clinical Trials Unit; "Fundamentals of Clinical Trials". More about the course… read more

Research Summary

Clare is currently the STM for the POISE, STADIA, SATURN and BLUSH clinical trials:

POISE: Hormone therapy for premature ovarian insufficiency (POI): randomised trial and long-term evaluation

STADIA: STAndardised DIagnostic Assessment for children and adolescents with emotional difficulties (STADIA): a multi-centre randomised controlled trial

SATURN: Stimulant Medication for ADHD and Tics - Understanding Response versus Non-stimulants (SATURN): a randomised trial of the clinical and cost-effectiveness of methylphenidate versus Guanfacine for ADHD in children and young people with a co-existing tic disorder

BLUSH: Oxybutynin or venlafaxine for hot flushes in women who cannot or choose not to use hormone replacement therapy: randomised trial and economic evaluation

Selected Publications

• UPTON, C. E., DANIELS, J. P. and DAVIES, M. C., 2021. Premature ovarian insufficiency: the need for evidence on the effectiveness of hormonal therapy: Climacteric Climacteric. 24(5), 453-458
• TAI, HY, UPTON, CE, WHITE, LJ, PINI, R, STORTI, G, MAZZOTTI, M, SHAKESHEFF, KM and HOWDLE, SM, 2010. Studies On The Interactions Of Co2 With Biodegradable Poly(Dl-Lactic Acid) And Poly(Lactic Acid-Co-Glycolic Acid) Copolymers Using High Pressure Atr-Ir And High Pressure Rheology Polymer. 51(6), 1425-1431
• KANCZLER, JM, MIRMALEK-SANI, SH, HANLEY, NA, IVANOV, AL, BARRY, JJA, UPTON, C, SHAKESHEFF, KM, HOWDLE, SM, ANTONOV, EN, BAGRATASHVILI, VN, POPOV, VK and OREFFO, ROC, 2009. Biocompatibility And Osteogenic Potential Of Human Fetal Femur-Derived Cells On Surface Selective Laser Sintered Scaffolds Acta Biomaterialia. 5(6), 2063-2071
• BARRY, JJA, EVSEEV, AV, MARKOV, MA, UPTON, CE, SCOTCHFORD, CA, POPOV, VK and HOWDLE, SM, 2008. In Vitro Study Of Hydroxyapatite-Based Photocurable Polymer Composites Prepared By Laser Stereolithography And Supercritical Fluid Extraction Acta Biomaterialia. 4(6), 1603-1610

• View all publications

Clare currently teaches the Approvals and Regulations session of a short course designed and delivered by the Nottingham Clinical Trials Unit; "Fundamentals of Clinical Trials". More about the course can be found at: https://www.nottingham.ac.uk/nctu/short-courses/index.aspx

• UPTON, C. E., DANIELS, J. P. and DAVIES, M. C., 2021. Premature ovarian insufficiency: the need for evidence on the effectiveness of hormonal therapy: Climacteric Climacteric. 24(5), 453-458
• TAI, HY, UPTON, CE, WHITE, LJ, PINI, R, STORTI, G, MAZZOTTI, M, SHAKESHEFF, KM and HOWDLE, SM, 2010. Studies On The Interactions Of Co2 With Biodegradable Poly(Dl-Lactic Acid) And Poly(Lactic Acid-Co-Glycolic Acid) Copolymers Using High Pressure Atr-Ir And High Pressure Rheology Polymer. 51(6), 1425-1431
• KANCZLER, JM, MIRMALEK-SANI, SH, HANLEY, NA, IVANOV, AL, BARRY, JJA, UPTON, C, SHAKESHEFF, KM, HOWDLE, SM, ANTONOV, EN, BAGRATASHVILI, VN, POPOV, VK and OREFFO, ROC, 2009. Biocompatibility And Osteogenic Potential Of Human Fetal Femur-Derived Cells On Surface Selective Laser Sintered Scaffolds Acta Biomaterialia. 5(6), 2063-2071
• BARRY, JJA, EVSEEV, AV, MARKOV, MA, UPTON, CE, SCOTCHFORD, CA, POPOV, VK and HOWDLE, SM, 2008. In Vitro Study Of Hydroxyapatite-Based Photocurable Polymer Composites Prepared By Laser Stereolithography And Supercritical Fluid Extraction Acta Biomaterialia. 4(6), 1603-1610
• GINTY, PJ, HOWARD, D, UPTON, CE, BARRY, JJA, ROSE, FRAJ, SHAKESHEFF, KM and HOWDLE, SM, 2008. A Supercritical Co2 Injection System For The Production Of Polymer/Mammalian Cell Composites Journal Of Supercritical Fluids. 43(3), 535-541
• UPTON, CE, HOWDLE, SM, SHAKESHEFF, KM and POPOV, VK, 2007. Three dimensional polymer scaffolds fabricated by surface selective laser sintering (SSLS) Tissue Engineering. 13(7), 1766-1767