I am a Professor of Respiratory Medicine specialising in high quality campus to clinic research.
My main research interest is in severe asthma, and I have published some of the most highly cited papers in this field over the past 8 years with 2 papers in the top 30 most highly cited asthma publications since 2006. My asthma projects are designed to improve the clinical knowledge and understanding of severe asthma by translating Nottingham's strengths in respiratory cell biology and MRI imaging into innovative clinical research asking important questions about disease monitoring and management.
Since my appointment as an Associate Professor in 2009 I have obtained £1.2M in grant income as a PI and £20M as a Co-I including funding from NIHR, EU IMI, charities and industry. I am the Nottingham lead in the largest asthma research consortium to date, the international £20M UBIOPRED EU IMI severe asthma project which is defining a phenotypic handprint in chronic severe asthma. I also helped design the MyAsthma app.
I am an expert in severe and difficult asthma. I lead Nottingham's nationally commissioned difficult asthma service. My research expertise includes clinical trial design, performance, monitoring and data interpretation.
I also co-lead the medical Informatics work stream at the East Midlands Academic Heath Sciences network, and the I am medicine divisional co-lead for the Research and Innovation department in Nottingham University Hospitals Trust.
Asthma, airways disease and respiratory emergencies, including provison of the respiratory taught course
Currently I have 3 areas of interest, all under the umbrella of asthma research. Firstly I am interested in the airway and airway epithelium. I have two projects; one examining the role of macrolide… read more
HALDAR, P., PAVORD, I.D., SHAW, D.E., BERRY, M.A., THOMAS, M., BRIGHTLING, C.E., WARDLAW, A.J. and GREEN, R.H., 2008. Cluster analysis and clinical asthma phenotypes American journal of respiratory and critical care medicine. 178(3), 218-224 THOMAS, M., MCKINLEY, R.K., MELLOR, S., WATKIN, G., HOLLOWAY, E., SCULLION, J., SHAW, D.E., WARDLAW, A., PRICE, D. and PAVORD, I., 2009. Breathing exercises for asthma: a randomised controlled trial Thorax. 64(1), 55-61 PATEL, M., PILCHER, J., TRAVERS, J., PERRIN, K., SHAW, D., BLACK, P., WEATHERALL, M. and BEASLEY, R., 2013. Use of metered-dose inhaler electronic monitoring in a real-world asthma randomized controlled trial: Journal of Allergy and Clinical Immunology: In Practice Journal of Allergy and Clinical Immunology: In Practice. 1(1), 83-91
SHAW, D., GREEN, R., BERRY, M., MELLOR, S., HARGADON, B., SHELLEY, M., MCKENNA, S., THOMAS, M. and PAVORD, I., 2012. A cross-sectional study of patterns of airway dysfunction, symptoms and morbidity in primary care asthma: Prim Care Respir J Prim Care Respir J. 21(3), 283-7
Currently I have 3 areas of interest, all under the umbrella of asthma research. Firstly I am interested in the airway and airway epithelium. I have two projects; one examining the role of macrolide antibiotics on the airway epithelium, using epithelial cells cultured from well phenotyped asthma patients and a second looking at distal airway inflammation using a small bronchial brush technique.
Continuing research from my thesis, I am evaluating the role of exhaled nitric oxide in treatment decisions in asthma care and have a funded study in this area.
Lastly I am investigating the role of the small airways in asthma using hyperpolarized xenon MRI imaging in animal models.
I am interested in developing the non-invasive assessment of airways disease.