School of Medicine
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People

Dominick Shaw

Professor and Honorary Consultant, Faculty of Medicine & Health Sciences

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Biography

I am a Professor of Respiratory Medicine specialising in high quality campus to clinic research.

My main research interest is in severe asthma, and I have published some of the most highly cited papers in this field over the past 8 years with 2 papers in the top 30 most highly cited asthma publications since 2006. My asthma projects are designed to improve the clinical knowledge and understanding of severe asthma by translating Nottingham's strengths in respiratory cell biology and MRI imaging into innovative clinical research asking important questions about disease monitoring and management.

Since my appointment as an Associate Professor in 2009 I have obtained £1.2M in grant income as a PI and £20M as a Co-I including funding from NIHR, EU IMI, charities and industry. I am the Nottingham lead in the largest asthma research consortium to date, the international £20M UBIOPRED EU IMI severe asthma project which is defining a phenotypic handprint in chronic severe asthma. I also helped design the MyAsthma app.

I am head of service for the respiratory speciality in Nottingham University Hospitals Trust.

Expertise Summary

At the start of 2020 I led the Respiratory response to Covid-19 in Nottingham University Hospitals Trust, the 4th largest Trust in the UK.

I am an expert in severe and difficult asthma. I lead Nottingham's nationally commissioned difficult asthma service. My research expertise includes clinical trial design, performance, monitoring and data interpretation.

Teaching Summary

Asthma, airways disease and respiratory emergencies

Research Summary

Currently I have 3 areas of interest, all under the umbrella of asthma research. Firstly I am interested in the airway and airway epithelium. I have two projects; one examining the role of macrolide… read more

Selected Publications

Current Research

Currently I have 3 areas of interest, all under the umbrella of asthma research. Firstly I am interested in the airway and airway epithelium. I have two projects; one examining the role of macrolide antibiotics on the airway epithelium, using epithelial cells cultured from well phenotyped asthma patients and a second looking at distal airway inflammation using a small bronchial brush technique.

Continuing research from my thesis, I am evaluating the role of exhaled nitric oxide in treatment decisions in asthma care and have a funded study in this area.

Lastly I am investigating the role of the small airways in asthma using hyperpolarized xenon MRI imaging in animal models.

Future Research

I am interested in developing the non-invasive assessment of airways disease.

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

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