Synthetic functions of airway structural cells (airway smooth muscle cells, fibroblasts, epithelial cells), particularly the expression and production of inflammatory cytokines, chemokines, growth factors, angiogenic factors, inflammatory enzymes and lipid mediators, and their role in the pathophysiology of asthma, idiopathic pulmonary fibrosis, COPD and cyctic fibrosis.
- Molecular mechanisms of transcriptional regulation of key genes in human airway structural cells, particularly epigenetic mechanisms, including transcription factor activation and promoter binding, histone modifications, promoter DNA methylation, epigenetic modifying enzyme activation and recruitment, and interactions between different epigenetic pathways.
- Molecular mechanism of action of drugs that target key gene expression and their therapeutic potential in in vitro cell model of respiratory diseases, providing the basis for further translational studies.
Airway inflammation and remodelling in chronic respiratory diseases.
Anti-inflammatory drug effect and molecular mechanisms.
Gene expression and regulation in respiratory structural cells.
I am a Professor of Molecular Medicine at the University of Nottingham based at Nottingham City Hospital. My main research interests are the role of airway structural cells in airway inflammation,… read more
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CLARKE, D.L., CLIFFORD, R.L., JINDARAT, S., PROUD, D., PANG, L., BELVISI, M. and KNOX, A.J., 2010. TNFα And IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein Journal Of Biological Chemistry. 285(38), 29101-29110