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Expertise Summary
Synthetic functions of airway structural cells (airway smooth muscle cells, fibroblasts, epithelial cells), particularly the expression and production of inflammatory cytokines, chemokines, growth factors, angiogenic factors, inflammatory enzymes and lipid mediators, and their role in the pathophysiology of asthma, idiopathic pulmonary fibrosis, COPD and cyctic fibrosis.
- Molecular mechanisms of transcriptional regulation of key genes in human airway structural cells, particularly epigenetic mechanisms, including transcription factor activation and promoter binding, histone modifications, promoter DNA methylation, epigenetic modifying enzyme activation and recruitment, and interactions between different epigenetic pathways.
- Molecular mechanism of action of drugs that target key gene expression and their therapeutic potential in in vitro cell model of respiratory diseases, providing the basis for further translational studies.
Teaching Summary
Airway inflammation and remodelling in chronic respiratory diseases.
Anti-inflammatory drug effect and molecular mechanisms.
Gene expression and regulation in respiratory structural cells.
Research Summary
I am a Professor of Molecular Medicine at the University of Nottingham based at Nottingham City Hospital. My main research interests are the role of airway structural cells in airway inflammation,… read more
Selected Publications
KONDRASHOV, A., MEIJER, H.A., BARTHET-BARATEIG, A., PARKER, H.N., KHURSHID, A., TESSIER, S., SICARD, M., KNOX, A.J., PANG, L. and DE MOOR, C.H., 2012. Inhibition of polyadenylation reduces inflammatory gene induction RNA. 18(12), 2236-2250 TATLER, A.L., JOHN, A.E., JOLLY, L., HABGOOD, A., PORTE, J., BRIGHTLING, C., KNOX, A.J., PANG, L., SHEPPARD, D., HUANG, X. and JENKINS, G., 2011. Integrin avβ5-mediated TGF-β activation by airway smooth muscle cells in asthma Journal of Immunology. 187(11), 6094-6107 COWARD, W.R., WATTS, K., FEGHALI-BOSTWICK, C.A., JENKINS, G. and PANG, L., 2010. Repression of IP-10 by interactions between histone deacetylation and hypermethylation in idiopathic pulmonary fibrosis Molecular and Cellular Biology. 30(12), 2874-2886 CLARKE, D.L., CLIFFORD, R.L., JINDARAT, S., PROUD, D., PANG, L., BELVISI, M. and KNOX, A.J., 2010. TNFα And IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein Journal Of Biological Chemistry. 285(38), 29101-29110