Understanding the importance of stress responses in cancer adaptation
Project fact file
Dr Alan McIntyre
School / Division
Division of Cancer and Stem Cells
High cost lab-based research
Regions of low oxygen (hypoxia) and acidosis are frequently found in solid tumours (in particular we work on breast, colon and brain tumours however other solid tumours are also relevant).
Clinically, hypoxia is associated with worse patient survival and resistance to chemotherapy and radiotherapy and acidosis increases tumour metastasis. An array of changes occur in response to hypoxia and acidosis leading to molecular adaptation through signalling, transcription, epigenetics and translation. Understanding these changes and the adaptations they enable will provide a better understanding of these therapy resistant microenvironments and therapeutic approaches to target these to improve patient survival. For an idea of the approaches and techniques please see our recent published data including da Motta et al 2017.
Available to Home/EU/International students.