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New therapeutic targets in breast cancer

Project fact file

Supervisor(s)
Dr Sarah Storr
School / Division
Division of Cancer and Stem Cells
Keywords
cancer Breast cancer metastasis prognosis
Fee band
High cost lab-based research
Date posted
November 2017

Project description

Cancer is one of the leading causes of death worldwide, with incidence of most tumour types increasing. Breast cancer is the most commonly diagnosed cancer in the UK, and is the second most common cause of cancer death. Although many women survive longer with breast cancer, a large number of women still die from this disease. Metastasis, the process of tumour cells migrating from the primary site to colonise a distant site is the leading cause of cancer death.

We are interested in the process of metastasis and how certain proteins influence that process in breast cancer – in particular we are interested in DARPP-32 (dopamine and cAMP regulated phosphoprotein of 32kDa). This project will investigate how phosphorylation of DARPP-32 effects how breast cancer cells behave in vitro, including its signalling partners. Various tissue culture techniques will be used, in addition to histopathology and molecular biology methodology.

Please email a CV with a covering letter to Dr Sarah Storr.

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

Contacts: Please see our 'contact us' page for further details